Protein Alignment bw and ABCG1

DIOPT Version :10

• Sequence 1: NP_523824.1
• Gene: bw / 37724
• FlyBaseID: FBgn0000241
• Length: 675
• Species: Drosophila melanogaster
• Sequence 2: XP_024307909.1
• Gene: ABCG1 / 9619
• HGNCID: 73
• Length: 786
• Species: Homo sapiens
• Alignment Length: 719
• Identity: 170/719 - (23%)
• Similarity: 305/719 - (42%)
• Gaps: 162/719 - (22%)

  Fly    10 QGGPS----LCLEWKQLNYYVPDQEQSNYSFWNECRKKRELRILQDASGHMKTGDLIAILGGSGA 70
            ||||.    :.:..|.|:..........:.|..:..::....:|:..||...:|:|:||:|.|||
Human   166 QGGPHHLGVVAISGKVLSAAHGAGRAYGWGFPGDPMEEGYKTLLKGISGKFNSGELVAIMGPSGA 230

  Fly    71 GKTTLLAAISQRLRGNLTGDVVLNGMAMERHQMTRISSFLPQFEINVKTFTAYEHLYFMSHFKMH 135
            ||:||:..::......:.|.|::||:..:.....::|.::.|.::.:...|..|.:...:|.|:.
Human   231 GKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQ 295

  Fly   136 RRTTKAEKRQRVADLLLAVGLRDAAHTRIQQLSGGERKRLSLAEELITDPIFLFCDEPTTGLDSF 200
            .:  ...:|:.|.::|.|:||...|:||...||||:||||::|.||:.:|..:|.||||:||||.
Human   296 EK--DEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSA 358

  Fly   201 SAYSVIKTLRHLCTRRRIAKHSLNQVYGEDSFETPSGESSASGSGSKSIEMEVVAESHESLLQTM 265
            |.:.|:..::.|                              ..|.:||
Human   359 SCFQVVSLMKGL------------------------------AQGGRSI---------------- 377

  Fly   266 RELPALGVLSNSPNGTHKKAAICSIHQPTSDIFELFTHIILMDGGRIVYQGRTEQAAKFFTDLGY 330
                                 ||:||||::.:||||..:.::..|:.||:|:......:..|||.
Human   378 ---------------------ICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGL 421

  Fly   331 ELPLNCNPADFYLKTLADKEGKENAGAVLRAKYEHETDGLYSGSWLLARSYSGD-----YLKH-- 388
            ..|...|||||.::..:.:.|.:|: .::||..|...|..:.      |...||     :|.|
Human   422 NCPTYHNPADFVMEVASGEYGDQNS-RLVRAVREGMCDSDHK------RDLGGDAEVNPFLWHRP 479

  Fly   389 ---VQNFKKIR------------------WIYQVYLLMVRFMTEDLR-----------NIRSGLI 421
               |:..|:::                  .:.|..:|..|.....:|           :|..||:
Human   480 SEEVKQTKRLKGLRKDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLL 544

  Fly   422 AFGFFMITAVTLSLMYSGIGGLTQRTVQDVGGSIFMLSNEMIFTFSYGVTYIFPAALPIIRREVG 486
                       :.|:|.|||...::.:.: .|.:|.....::|.........||..:.:..||..
Human   545 -----------IGLLYLGIGNEAKKVLSN-SGFLFFSMLFLMFAALMPTVLTFPLEMGVFLREHL 597

  Fly   487 EGTYSLSAYYVALVLSFVPVAFFKGYVFLSVIYASIYY--------TRGFLLYLSMGFLMSLSAV 543
            ...|||.|||:|..::.||.     .:...|.|.||.|        ...|:|:.::|.:.||
Human   598 NYWYSLKAYYLAKTMADVPF-----QIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTMTSL--- 654

  Fly   544 AAVGYGVFLSSLFESDKMASECAAPFDLIFLIFGGTYMNVDTVP----GLKYLSLFFYSNEALMY 604
            .|...|:.:.:...|.::|:.......:..|:|.|.:::.||:|    .:.|:|...|..|.::.
Human   655 VAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGFEGVIL 719

  Fly   605 KFW-IDIDNIDCPVNEDHPC-IKTGVEVLQQGSYRNADYTYWLDCFSLVVVAVIFHIVSFGLVRR 667
            ..: :|.:::.|.:  |..| .:....:|::....||  ..:||   .:|:.:.|  :|..|:..
Human   720 SIYGLDREDLHCDI--DETCHFQKSEAILRELDVENA--KLYLD---FIVLGIFF--ISLRLIAY 775

  Fly   668 YIHR 671
            ::.|
Human   776 FVLR 779

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bw	NP_523824.1	3a01204	40..673	CDD:273361	163/685 (24%)
ABCG1	XP_024307909.1	3a01204	202..786	CDD:273361	163/683 (24%)