Protein Alignment bw and ABCG2

DIOPT Version :9

• Sequence 1: NP_001286769.1
• Gene: bw / 37724
• FlyBaseID: FBgn0000241
• Length: 675
• Species: Drosophila melanogaster
• Sequence 2: NP_001335914.1
• Gene: ABCG2 / 9429
• HGNCID: 74
• Length: 655
• Species: Homo sapiens
• Alignment Length: 707
• Identity: 170/707 - (24%)
• Similarity: 286/707 - (40%)
• Gaps: 160/707 - (22%)

  Fly    14 SLCLEWKQLNYYVPDQEQSNYSFWNECRKKRELRILQDASGHMKTGDLIAILGGSGAGKTTLLAA 78
            ::|...|..:.::|            |||..|..||.:.:|.||.| |.||||.:|.||::||..
Human    41 NICYRVKLKSGFLP------------CRKPVEKEILSNINGIMKPG-LNAILGPTGGGKSSLLDV 92

  Fly    79 ISQRL-RGNLTGDVVLNGMAMERHQMTRISSFLPQFEINVKTFTAYEHLYFMSHFKMHRRTTKAE 142
            ::.|. ...|:|||::|| |.........|.::.|.::.:.|.|..|:|.|.:..::....|..|
Human    93 LAARKDPSGLSGDVLING-APRPANFKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHE 156

  Fly   143 KRQRVADLLLAVGLRDAAHTR-----IQQLSGGERKRLSLAEELITDPIFLFCDEPTTGLDSFSA 202
            |.:|:..::..:||...|.::     |:.:|||||||.|:..||||||..||.|||||||||.:|
Human   157 KNERINRVIQELGLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTA 221

  Fly   203 YSVIKTLRHLCTRRRIAKHSLNQVYGEDSFETPSGESSASGSGSKSIEMEVVAESHESLLQTMRE 267
            .:|:..|      :|::|..
Human   222 NAVLLLL------KRMSKQG--------------------------------------------- 235

  Fly   268 LPALGVLSNSPNGTHKKAAICSIHQPTSDIFELFTHIILMDGGRIVYQGRTEQAAKFFTDLGYEL 332
                            :..|.|||||...||:||..:.|:..||:::.|..::|..:|...||..
Human   236 ----------------RTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHC 284

  Fly   333 PLNCNPADFYLKTLADKEGKENAGAVLRAKYEHETD----------------GLYSGSWL----- 376
            ....|||||:|..:   .|...|.|:.|.:....|:                .:|..|..
Human   285 EAYNNPADFFLDII---NGDSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKETK 346

  Fly   377 --LARSYSGDYLKHVQNFKKI----------RWIYQVYLLMVRFMTEDLRNIRSGLIAFGFFMIT 429
              |.:...|:..|.:..||:|          ||:.:      |.....|.|.::.:......::.
Human   347 AELHQLSGGEKKKKITVFKEISYTTSFCHQLRWVSK------RSFKNLLGNPQASIAQIIVTVVL 405

  Fly   430 AVTLSLMYSGIGGLTQRTVQDVGGSIFMLSNEMIFTFSYGVTYIFPAALPIIRREVGEGTYSLSA 494
            .:.:..:|.|:.. ....:|:..|.:|.|:....|: |.....:|.....:...|...|.|.:|:
Human   406 GLVIGAIYFGLKN-DSTGIQNRAGVLFFLTTNQCFS-SVSAVELFVVEKKLFIHEYISGYYRVSS 468

  Fly   495 YYVALVLS-FVPVAFFKGYVFLSVIY--------ASIYYTRGFLLYLSMGFLMSLSAVAAVGYGV 550
            |::..:|| .:|:......:|..::|        |..::...|.|.:......|::...|.|..|
Human   469 YFLGKLLSDLLPMRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIAAGQSV 533

  Fly   551 FLSSLFESDKMASECAAPFDLIFLIFGGTYMNVDTVPG----LKYLSLFFYSNEALMYKFWIDID 611
            .        .:|:.......:..:||.|..:|:.|:..    |:|.|:..|...||.:..::. .
Human   534 V--------SVATLLMTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFLG-Q 589

  Fly   612 NIDCP---VNEDHPC---IKTGVEVLQQGSYRNADYTYWLDCFSLVVVAVIFHIVSF 662
            |. ||   ...::||   ..||.|.|.:.....:.:..|.:..:|..:.|||..:::
Human   590 NF-CPGLNATGNNPCNYATCTGEEYLVKQGIDLSPWGLWKNHVALACMIVIFLTIAY 645

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bw	NP_001286769.1	P-loop_NTPase	31..316	CDD:304359	86/290 (30%)
		3a01204	40..673	CDD:273361	167/681 (25%)
		ABC2_membrane	404..604	CDD:279410	41/212 (19%)
ABCG2	NP_001335914.1	3a01204	55..649	CDD:273361	167/681 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820