DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bw and ABCG24

DIOPT Version :9

Sequence 1:	NP_001286769.1	Gene:	bw / 37724	FlyBaseID:	FBgn0000241	Length:	675	Species:	Drosophila melanogaster
Sequence 2:	NP_175745.4	Gene:	ABCG24 / 841775	AraportID:	AT1G53390	Length:	1109	Species:	Arabidopsis thaliana

Alignment Length:	805	Identity:	171/805 - (21%)
Similarity:	286/805 - (35%)	Gaps:	282/805 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SGGSSGQGGPSLCLEWK---------------QLNYYVPD---------QEQSNYSF-------W 37
            :.||:|:.  ||.:|.|               |:..|..|         ||..|.:|       .
plant   433 AAGSNGRA--SLGIEGKRVKGQTLAKIKKTQSQIFKYAYDRIEKEKAMEQENKNLTFSGIVKMAT 495

  Fly    38 NECRKKREL-----------------RILQDASGHMKTGDLIAILGGSGAGKTTLLAAISQRLRG 85
            |...:||.|                 ::|:..:|.||.|.:.|::|.||||||:||:|::.:..|
plant   496 NSETRKRHLMELSFKDLTLTLKSNGKQVLRCVTGSMKPGRITAVMGPSGAGKTSLLSALAGKAVG 560

  Fly    86 -NLTGDVVLNGMAMERHQMTRISSFLPQFEINVKTFTAYEHLYFMSHFKMHRRTTKAEK---RQR 146
             .|:|.:::||.....|...:|..|:||.::.....|..|:|:|.:..::....:||:|   .:|
plant   561 CKLSGLILINGKQESIHSYKKIIGFVPQDDVVHGNLTVEENLWFHAKCRLPADLSKADKVLVVER 625

  Fly   147 VADLLLAVGLRDAAHTRIQQ--LSGGERKRLSLAEELITDPIFLFCDEPTTGLDSFSAYSVIKTL 209
            :.|.|....:|.:....:::  :|||:|||:::..|::.:|..||.||||:||||.|:..:::.|
plant   626 IIDSLGLQAVRSSLVGTVEKRGISGGQRKRVNVGLEMVMEPSVLFLDEPTSGLDSASSQLLLRAL 690

  Fly   210 RHLCTRRRIAKHSLNQVYGEDSFETPSGESSASGSGSKSIEMEVVAESHESLLQTMRELPALGVL 274
            ||                                   :::|                     ||
plant   691 RH-----------------------------------EALE---------------------GV- 698

  Fly   275 SNSPNGTHKKAAICS-IHQPTSDIFELFTHIILM-DGGRIVYQGRTEQAAKFFTDLGYELPLNCN 337
                       .||. :|||:..:|:.|..::|: .||..||.|...:..::|:.||..:|...|
plant   699 -----------NICMVVHQPSYTLFKTFNDLVLLAKGGLTVYHGSVNKVEEYFSGLGIHVPDRIN 752

  Fly   338 PADFYLKTLADKEG-------------------------------KENAGAVLRAKYEHETDGLY 371
            |.|:|:..|   ||                               :.|:.|.|....:..|:...
plant   753 PPDYYIDVL---EGVVISMGNSGIGYKELPQRWMLHKGYSVPLDMRNNSAAGLETNPDLGTNSPD 814

  Fly   372 SGSWLLARS----------YSGDYLKHVQNFKKIR----------WIYQVYLLMVRFMTEDLRNI 416
            :.....||.          ...|.::|  ||.|.|          |:...|.| .|...:.:|..
plant   815 NAEQTFARELWRDVKSNFRLRRDKIRH--NFLKSRDLSHRRTPSTWLQYKYFL-GRIAKQRMREA 876

  Fly   417 RSGLIAFGFFMITAVTLSLMYSGIGGLTQRTVQDVGGSIFMLSNEMIFTFSYGVTYIFPAALPII 481
            :.....:...::....|                   ||:...|:|......|..|.|..:.|..|
plant   877 QLQATDYLILLLAGACL-------------------GSLIKASDESFGAPGYIYTIIAVSLLCKI 922

  Fly   482 R-------------REVGEGTYSLSAYYVA---------LVLSFVPVA-----------FFKGYV 513
            .             ||...| .|.||.::|         ||...|.::           ||..|:
plant   923 AALRSFSLDKLHYWRESASG-MSSSACFLAKDTIDIFNILVKPLVYLSMFYFFTNPRSTFFDNYI 986

  Fly   514 FLSVIYASIYYTRGFLLYLSMGFLMSLSAVAAVGYGVFLSSLFESDKMASECAAPFDLIFLIFGG 578
               |:...:|...|....|::....|.:.:.:|...|.|:.:....|.:       :||.:|...
plant   987 ---VLVCLVYCVTGIAYALAIFLQPSTAQLFSVLLPVVLTLVATQPKNS-------ELIRIIADL 1041

  Fly   579 TYMNVDTVPGLKY-LSLFFYSNEALMYKFWIDIDNIDCPVNEDHPCIKTGVEVLQQGSYRNADYT 642
            :|.        |: |..|...|....|..|:        :......:|:|.           |..
plant  1042 SYP--------KWALEAFVIGNAQKYYGVWM--------ITRCGSLMKSGY-----------DIN 1079

  Fly   643 YWLDCFSLVVVAVIFHIVSFGLVRR 667
            .|..|..::::.        ||..|
plant  1080 KWSLCIMILLLV--------GLTTR 1096

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bw	NP_001286769.1	P-loop_NTPase	31..316	CDD:304359	80/316 (25%)
		3a01204	40..673	CDD:273361	156/738 (21%)
		ABC2_membrane	404..604	CDD:279410	43/233 (18%)
ABCG24	NP_175745.4	EcfA2	504..736	CDD:224047	76/299 (25%)
		ABCG_EPDR	505..731	CDD:213180	74/293 (25%)
		ABC2_membrane	867..>1006	CDD:304374	29/161 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.870