DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bw and abcg2a

DIOPT Version :9

Sequence 1:	NP_001286769.1	Gene:	bw / 37724	FlyBaseID:	FBgn0000241	Length:	675	Species:	Drosophila melanogaster
Sequence 2:	XP_021325521.1	Gene:	abcg2a / 735312	ZFINID:	ZDB-GENE-050517-35	Length:	644	Species:	Danio rerio

Alignment Length:	732	Identity:	173/732 - (23%)
Similarity:	306/732 - (41%)	Gaps:	173/732 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SGGSSGQGGPSLCLEWKQLNYYVPDQEQSNYSFWNECR-KKRELRILQDASGHMKTGDLIAILGG 67
            :|.||........:.:..:||.:  :.:|.:     |: |..:..||...:|.||.| |.||||.
Zfish    20 TGVSSSPSRRGATVSFHNINYSL--KMKSGF-----CKSKSTKKNILIGLNGIMKPG-LNAILGA 76

  Fly    68 SGAGKTTLLAAISQRL-RGNLTGDVVLNGMAMERHQMTRISSFLPQFEINVKTFTAYEHLYFMSH 131
            :|:||::.|..::.|. ...|:|:|:::| |.:......:|.::.|.::.:.|.|..|:|.|.:.
Zfish    77 TGSGKSSFLDVLAARKDPAGLSGEVLIDG-APQPPNFKCLSGYVVQDDVVMGTLTVRENLRFSAA 140

  Fly   132 FKMHRRTTKAEKRQRVADLLLAVGLRDAAHTR-----IQQLSGGERKRLSLAEELITDPIFLFCD 191
            .::.:...:.||.::|..|:..:||...|.:|     |:.:|||||||.::..|||.||..||.|
Zfish   141 LRLPKSIKQREKDEKVERLIQELGLSKVADSRVGTQLIRGVSGGERKRTNIGMELIIDPPVLFLD 205

  Fly   192 EPTTGLDSFSAYSVIKTLRHLCTRRRIAKHSLNQVYGEDSFETPSGESSASGSGSKSIEMEVVAE 256
            |||||||:.:|.||:..|:.:
Zfish   206 EPTTGLDASTANSVLMLLKKM-------------------------------------------- 226

  Fly   257 SHESLLQTMRELPALGVLSNSPNGTHKKAAICSIHQPTSDIFELFTHIILMDGGRIVYQGRTEQA 321
                                   |.:.:..|.|||||...|:.||..:.|:.||::||.|..:.|
Zfish   227 -----------------------GNNGRTIILSIHQPRYSIYRLFDSLTLLVGGKLVYHGPAQDA 268

  Fly   322 AKFFTDLGYELPLNCNPADFYLKTLADKEGKENAGAVLRAKYEHETD---------GL------- 370
            ..:|:.:||....:.|||||:|    |....:::...|...||...|         |:
Zfish   269 LSYFSQIGYTCEPHNNPADFFL----DVINGDSSAVTLNKLYEEVVDQDQLSSSLKGIEDRLVEE 329

  Fly   371 YSGSWLLARSYSGDYLKHVQ-----NFKKIRWI-------YQVYLLMVRFMTEDLRNIRSGLIAF 423
            |..|.:..:::: |..:.||     ...|.|.|       :|.:.::.|.....:.|.::.:...
Zfish   330 YQRSSIFQQTHA-DLQRIVQGQDYSTRPKSRTITYSTSFCHQFHWVLKRTFRNLMLNPQTSVAQI 393

  Fly   424 GFFMITAVTLSLMYSGIGGLTQRTVQDVGGSIFMLSNEMIFTFSYGVTYIFPAALPIIRREVGEG 488
            |..:..|:.:..::.|:.. ....:|:..|::|.::....|: |.....:|.|...:...|...|
Zfish   394 GVMIFLALVVGAIFFGVAE-NSSGIQNRMGALFFITTNQCFS-SVSAAELFIAERKLFVHEYISG 456

  Fly   489 TYSLSAYYVALVLS------------FVPVAFF---------KGYVFL-SVIYASIYYTRGFLLY 531
            .|.:|.|:::.:||            |..||:|         ..::|| |:|..|         |
Zfish   457 YYRVSVYFLSKILSDILTLRTIPAVIFSCVAYFMIGLKPAAEAFFIFLFSIIMVS---------Y 512

  Fly   532 LSMGFLMSLSA---VAAVGYGVFLSSLFESDKMASECAAPFDLIFLIFGGTYMNVDTVP----GL 589
            .:....:::||   |.|:. .:|::..|              :..:||.|..:|:.:|.    .|
Zfish   513 TATAMTLAISADQTVVAIA-NIFMTISF--------------VFMMIFSGLLVNLPSVATWLNWL 562

  Fly   590 KYLSLFFYSNEALMYKFWIDIDNIDCPVNEDHPCIKTGVEVLQQGSYRNADYTYWLDCFSLVVVA 654
            ||.|:..|...||....:..:...|...|....| .:|.|.||:.....:.:..|.:..:|.::.
Zfish   563 KYFSIPRYGLSALQINEFTGLFFCDNRNNSGSVC-SSGEEFLQEQGIDYSAWGLWQNHLALGIMT 626

  Fly   655 VIFHIVSFGLVRRYIHR 671
            .||..::: |..|:|.:
Zfish   627 FIFLCIAY-LKLRFIKK 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bw	NP_001286769.1	P-loop_NTPase	31..316	CDD:304359	81/291 (28%)
		3a01204	40..673	CDD:273361	167/696 (24%)
		ABC2_membrane	404..604	CDD:279410	47/228 (21%)
abcg2a	XP_021325521.1	PRK10535	43..638	CDD:333000	166/701 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920