Protein Alignment bw and ABCG8

DIOPT Version :10

• Sequence 1: NP_523824.1
• Gene: bw / 37724
• FlyBaseID: FBgn0000241
• Length: 675
• Species: Drosophila melanogaster
• Sequence 2: NP_071882.1
• Gene: ABCG8 / 64241
• HGNCID: 13887
• Length: 673
• Species: Homo sapiens
• Alignment Length: 753
• Identity: 178/753 - (23%)
• Similarity: 302/753 - (40%)
• Gaps: 219/753 - (29%)

  Fly     8 SGQGGPSLCLEWKQLNY------YVPDQEQ-SNYSF-WN--ECRKKRELRILQDASGHMKTGDLI 62
            |||  |: .||.:.|||      .||..|| :.:.. |.  .|:...||.| |:.|..:::|.::
Human    41 SGQ--PN-TLEVRDLNYQVDLASQVPWFEQLAQFKMPWTSPSCQNSCELGI-QNLSFKVRSGQML 101

  Fly    63 AILGGSGAGKTTLLAAISQRLRGN--LTGDVVLNGMAMERHQMTRISSFLPQFEINVKTFTAYEH 125
            ||:|.||.|:.:||..|:.|..|.  .:|.:.:||.......:.:..:.:.|....:...|..|.
Human   102 AIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQLVRKCVAHVRQHNQLLPNLTVRET 166

  Fly   126 LYFMSHFKMHRRTTKAEKRQRVADLLLAVGLRDAAHTR-----IQQLSGGERKRLSLAEELITDP 185
            |.|::..::.|..::|::.:||.|::..:.||..|.||     ::.||||||:|:|:..:|:.:|
Human   167 LAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCADTRVGNMYVRGLSGGERRRVSIGVQLLWNP 231

  Fly   186 IFLFCDEPTTGLDSFSAYSVIKTLRHLCTRRRIAKHSLNQVYGEDSFETPSGESSASGSGSKSIE 250
            ..|..||||:|||||:|::::|||..|....|:
Human   232 GILILDEPTSGLDSFTAHNLVKTLSRLAKGNRL-------------------------------- 264

  Fly   251 MEVVAESHESLLQTMRELPALGVLSNSPNGTHKKAAICSIHQPTSDIFELFTHIILMDGGRIVYQ 315
                                               .:.|:|||.||||.||..::||..|..:|.
Human   265 -----------------------------------VLISLHQPRSDIFRLFDLVLLMTSGTPIYL 294

  Fly   316 GRTEQAAKFFTDLGYELPLNCNPADFYLK-TLADKEGKENAGAVLRAKYEHETDGLYSGSWLLAR 379
            |..:...::||.:||..|...||||||:. |..|:..:|...|. |.|               |:
Human   295 GAAQHMVQYFTAIGYPCPRYSNPADFYVDLTSIDRRSREQELAT-REK---------------AQ 343

  Fly   380 SYSGDYLKHVQNFKKIRW----------------------------------IYQVYLLMVRFMT 410
            |.:..:|:.|::.....|                                  :.|...|:.|.::
Human   344 SLAALFLEKVRDLDDFLWKAETKDLDEDTCVESSVTPLDTNCLPSPTKMPGAVQQFTTLIRRQIS 408

  Fly   411 EDLRNIRSGLIAFGFFMITAVTLSLMYSGIGGLTQRTVQDVGGSIFMLSNEMIFTFSYGVTYIFP 475
            .|.|::.:.||......:.::|:..:|.|.|.: |.:..|....:||:          |....|.
Human   409 NDFRDLPTLLIHGAEACLMSMTIGFLYFGHGSI-QLSFMDTAALLFMI----------GALIPFN 462

  Fly   476 AALPIIRR----------EVGEGTYSLSAYYVALVLSFVPVAFFKGYVFLSVIYASIYY------ 524
            ..|.:|.:          |:.:|.|:...|:.|.:|..:|.  ...|:   :||....|
Human   463 VILDVISKCYSERAMLYYELEDGLYTTGPYFFAKILGELPE--HCAYI---IIYGMPTYWLANLR 522

  Fly   525 --TRGFLLYLSMGFL-------MSLSAVAAVG----YGVFLSSLFESDKMASECAAPFDLIFLIF 576
              .:.|||:..:.:|       |:|:|.|.:.    ...|.::|:.|              |.:.
Human   523 PGLQPFLLHFLLVWLVVFCCRIMALAAAALLPTFHMASFFSNALYNS--------------FYLA 573

  Fly   577 GGTYMNVD---TVPG-LKYLSLFFYSNEALM--------YKFWIDIDNIDCPVNEDHPCIKTGVE 629
            ||..:|:.   |||. :..:|...:..|.||        ||  :.:.|:...|:.|..     :.
Human   574 GGFMINLSSLWTVPAWISKVSFLRWCFEGLMKIQFSRRTYK--MPLGNLTIAVSGDKI-----LS 631

  Fly   630 VLQQGSYRNADYTYWLDCFSLVVVAVIFHIVSFGLVRR 667
            |::..||  ..|..:|....|....::.:.||...:::
Human   632 VMELDSY--PLYAIYLIVIGLSGGFMVLYYVSLRFIKQ 667

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bw	NP_523824.1	3a01204	40..673	CDD:273361	164/711 (23%)
ABCG8	NP_071882.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..25
		ABCG_White	60..295	CDD:213201	81/302 (27%)
		3a01204	88..663	CDD:273361	161/697 (23%)