Protein Alignment bw and ABCG4

DIOPT Version :9

• Sequence 1: NP_001286769.1
• Gene: bw / 37724
• FlyBaseID: FBgn0000241
• Length: 675
• Species: Drosophila melanogaster
• Sequence 2: NP_001135977.1
• Gene: ABCG4 / 64137
• HGNCID: 13884
• Length: 646
• Species: Homo sapiens
• Alignment Length: 687
• Identity: 157/687 - (22%)
• Similarity: 282/687 - (41%)
• Gaps: 142/687 - (20%)

  Fly    17 LEWKQLNYYVPDQEQSNYSFWNECRKKRELR-ILQDASGHMKTGDLIAILGGSGAGKTTLLAAIS 80
            :|:.:|:|.|.:         ..|.:||..: :|:..||.....:||.|:|.|||||:|.:..::
Human    61 IEFVELSYSVRE---------GPCWRKRGYKTLLKCLSGKFCRRELIGIMGPSGAGKSTFMNILA 116

  Fly    81 QRLRGNLTGDVVLNGMAMERHQMTRISSFLPQFEINVKTFTAYEHLYFMSHFKMHRRTTKAEKRQ 145
            ......:.|.:::||...|.....::|.::.|.::.:...|..|.:...::.|:..:  :..|::
Human   117 GYRESGMKGQILVNGRPRELRTFRKMSCYIMQDDMLLPHLTVLEAMMVSANLKLSEK--QEVKKE 179

  Fly   146 RVADLLLAVGLRDAAHTRIQQLSGGERKRLSLAEELITDPIFLFCDEPTTGLDSFSAYSVIKTLR 210
            .|.::|.|:||...:|||...||||:||||::|.||:.:|..:|.||||:||||.|.:.|:..::
Human   180 LVTEILTALGLMSCSHTRTALLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMK 244

  Fly   211 HLCTRRRIAKHSLNQVYGEDSFETPSGESSASGSGSKSIEMEVVAESHESLLQTMRELPALGVLS 275
            .|                              ..|.::|
Human   245 SL------------------------------AQGGRTI-------------------------- 253

  Fly   276 NSPNGTHKKAAICSIHQPTSDIFELFTHIILMDGGRIVYQGRTEQAAKFFTDLGYELPLNCNPAD 340
                       ||:||||::.:||:|..:.::..|:.:::|.......:...||...|...||||
Human   254 -----------ICTIHQPSAKLFEMFDKLYILSQGQCIFKGVVTNLIPYLKGLGLHCPTYHNPAD 307

  Fly   341 FYLKTLADKEGKENAGAVLRAKYEHETDGLYSGSWLLARSYSGDYLKHV---------------Q 390
            |.::..:.:.|..|. .:.||        :.:|...:|...|......|               .
Human   308 FIIEVASGEYGDLNP-MLFRA--------VQNGLCAMAEKKSSPEKNEVPAPCPPCPPEVDPIES 363

  Fly   391 NFKKIRWIYQVYLLMVRFMTEDLRNIRSGLIAFGFFMITAVTLSLMYSGIGGLTQRTVQDVGGSI 455
            :......:.|..:|..|.....||:.....:.|...::..|.:.|:|..||....:...:. |.:
Human   364 HTFATSTLTQFCILFKRTFLSILRDTVLTHLRFMSHVVIGVLIGLLYLHIGDDASKVFNNT-GCL 427

  Fly   456 FMLSNEMIFTFSYGVTYIFPAALPIIRREVGEGTYSLSAYYVALVLSFVPVAFFKGYVFLSVIYA 520
            |.....::|.........||..:.:..||.....|||.|||:|..::.||.     .|...|:|.
Human   428 FFSMLFLMFAALMPTVLTFPLEMAVFMREHLNYWYSLKAYYLAKTMADVPF-----QVVCPVVYC 487

  Fly   521 SIYY--------TRGFLLYLSMGFLMSLSAVAAVGYGVFLSSLFESDKMASECAAPFDLIFLIFG 577
            ||.|        |..|||:.:   |.:.:|:.|...|:.:.:...|.::|:.......:..|:|.
Human   488 SIVYWMTGQPAETSRFLLFSA---LATATALVAQSLGLLIGAASNSLQVATFVGPVTAIPVLLFS 549

  Fly   578 GTYMNVDTVPGL----KYLSLFFYSNEALMYKFW----IDIDNID--CPVNEDHPCIKT-GVEVL 631
            |.:::..|:|..    .|||...|..|.::...:    .|:..::  ||..|....::. .||
Human   550 GFFVSFKTIPTYLQWSSYLSYVRYGFEGVILTIYGMERGDLTCLEERCPFREPQSILRALDVE-- 612

  Fly   632 QQGSYRNADYTYWLDCFSLVVVAVIFHIVSFGLVRRY 668
                    |...::|...|.:..:...:::: ||.||
Human   613 --------DAKLYMDFLVLGIFFLALRLLAY-LVLRY 640

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bw	NP_001286769.1	P-loop_NTPase	31..316	CDD:304359	70/285 (25%)
		3a01204	40..673	CDD:273361	153/664 (23%)
		ABC2_membrane	404..604	CDD:279410	52/211 (25%)
ABCG4	NP_001135977.1	3a01204	44..646	CDD:273361	157/687 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810