DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bw and abcg2c

DIOPT Version :9

Sequence 1:	NP_001286769.1	Gene:	bw / 37724	FlyBaseID:	FBgn0000241	Length:	675	Species:	Drosophila melanogaster
Sequence 2:	XP_005156580.1	Gene:	abcg2c / 569858	ZFINID:	ZDB-GENE-050517-37	Length:	640	Species:	Danio rerio

Alignment Length:	698	Identity:	176/698 - (25%)
Similarity:	299/698 - (42%)	Gaps:	146/698 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 GPSLCLEWKQLNYYVPDQEQSNYSFWNECRKKRELRILQDASGHMKTGDLIAILGGSGAGKTTLL 76
            ||:  :.:.|:.|.:.::.......|      ||..||:|.||.|..| :.||:|.:|:|||:||
Zfish    32 GPT--VTFHQIRYRIKERLGMFSCQW------REKDILKDVSGIMNPG-MNAIMGPTGSGKTSLL 87

  Fly    77 AAISQRL--RGNLTGDVVLNGMAMERHQMTRISSFLPQFEINVKTFTAYEHLYFMSHFKMH-RRT 138
            ..|:.|.  :|..:|.|:::. .:....:...|:::.|.:|.:.|.|..|:|.|.::.::. :..
Zfish    88 DVIAGRKDPKGLKSGQVLVDN-TIVTSDLRLCSAYVVQNDILMGTLTVRENLAFSANLRLSLKEY 151

  Fly   139 TKAEKRQRVADLLLAVGLRDAAHTRI-----QQLSGGERKRLSLAEELITDPIFLFCDEPTTGLD 198
            :.::|..||..::..:||:|.|.|:|     :.:||||:||.|:..||||.|..||.||||||||
Zfish   152 SSSDKEMRVNSVIQELGLKDCADTKIGTMFLRGVSGGEKKRCSIGMELITSPSLLFLDEPTTGLD 216

  Fly   199 SFSAYSVIKTLRHLCTRRRIAKHSLNQVYGEDSFETPSGESSASGSGSKSIEMEVVAESHESLLQ 263
            :.:|.|:::.|:::
Zfish   217 ANTANSIMELLQNI--------------------------------------------------- 230

  Fly   264 TMRELPALGVLSNSPNGTHKKAAICSIHQPTSDIFELFTHIILMDGGRIVYQGRTEQAAKFFTDL 328
                         |..|   |..|.|||||...||..|.|:.||:.|.|:|.|..::|..:|.||
Zfish   231 -------------SKKG---KTVIFSIHQPRYSIFRQFDHLTLMNKGEIIYAGAADKAIIYFEDL 279

  Fly   329 GYEL-PLNCNPADFYL------------------KTLADKE--GKENAGAVLRAKYEHET----- 367
            ||:. |.| |||||:|                  |..:.:|  ..||..||:..|..:.|
Zfish   280 GYKCEPFN-NPADFFLDVTNGTIRPHKSSNNISEKCSSSEEMVDNENPLAVMYRKSPYFTKLKDR 343

  Fly   368 -----DGLYSGSWLLARSYSGDYLKHVQNFKKIRWIYQVYLLMVRFMTEDLRNIRSGLIAFGFFM 427
                 |||.      .....||.:.:...|     .||:.|:..|.:...|||.::........:
Zfish   344 LTEISDGLD------PEVTKGDKIGYATPF-----YYQLLLVSGRTIRNILRNPQTSYAQLFLNI 397

  Fly   428 ITAVTLSLMYSGIGGLTQRTVQDVGGSIFMLSNEMIFTFSYGVTYIFPAALPIIRREVGEGTYSL 492
            ...:.:.|:|..|.......:|:..|:.|.|...|:|. :.....:|.:...:...|...|.|..
Zfish   398 FFGILVGLIYYQIPHTLPEALQNRTGAFFFLVINMVFG-NLSAVELFVSERELFIHENSSGFYRT 461

  Fly   493 SAYYVALVLS-FVPVAFFKGYVFLSVIYASIYY---TRGFLLYLSMGFLMSLSAVAAVGYGVFLS 553
            |||:::.|.: .:|......::|.::.|..:..   ...|.||.   ..||:.:::||.....:|
Zfish   462 SAYFLSKVFADLIPNRILPVFIFSAIPYFMMGLKPEVEAFFLYC---VTMSMVSLSAVSLAFLVS 523

  Fly   554 SLFESDKMASECAAPFDLIFLIFGGTYMNVDT----VPGLKYLSLFFYSNEALMYKFWIDIDNID 614
            :...|..||:...|...:..::|||..:|:::    :..||:.|:|.|...||.      |:.:.
Zfish   524 ASVGSFAMANILIALPYVFMMVFGGFLVNLNSMLSGLSWLKWASIFRYGYNALA------INELK 582

  Fly   615 CPVNEDHPCIKTGVEVLQQGSYRNADYTYWLDCFSLVVVAVIFHIVSF 662
            ..|..|:....||...|.......:.:.:|.:..:|..:..:..|:::
Zfish   583 DQVFTDNLTRVTGDMYLDHQEIDRSAWGFWENQVALAGIMFVCLILAY 630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bw	NP_001286769.1	P-loop_NTPase	31..316	CDD:304359	84/292 (29%)
		3a01204	40..673	CDD:273361	171/670 (26%)
		ABC2_membrane	404..604	CDD:279410	47/207 (23%)
abcg2c	XP_005156580.1	ABCG_EPDR	34..267	CDD:213180	86/309 (28%)
		3a01204	37..638	CDD:273361	174/691 (25%)
		ABC2_membrane	377..579	CDD:279410	47/211 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820