DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bw and abcg1

DIOPT Version :9

Sequence 1:	NP_001286769.1	Gene:	bw / 37724	FlyBaseID:	FBgn0000241	Length:	675	Species:	Drosophila melanogaster
Sequence 2:	NP_001103924.1	Gene:	abcg1 / 556979	ZFINID:	ZDB-GENE-070424-84	Length:	673	Species:	Danio rerio

Alignment Length:	695	Identity:	165/695 - (23%)
Similarity:	302/695 - (43%)	Gaps:	144/695 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PSLCLEWKQLNYYVPDQEQSNYSFWNECRKKRELRILQDASGHMKTGDLIAILGGSGAGKTTLLA 77
            |::.:|:|.|:|.||:.     .:|   |||....:|:..||:...|.|:||:|.|||||:||:.
Zfish    80 PAVNIEFKDLSYSVPEG-----PWW---RKKGYKTLLKGISGNFTGGALVAIMGPSGAGKSTLMN 136

  Fly    78 AISQRLRGNLTGDVVLNGMAMERHQMTRISSFLPQFEINVKTFTAYEHLYFMSHFKMHRRTTKAE 142
            .::......:.|::::||...:.....::|.::.|.::.:...|..|.:...::.|:..:  ...
Zfish   137 ILAGYRETGMKGEILINGHPRDLRSFRKVSCYIMQDDMLLPHLTVQEAMMVSANLKLQEK--DEG 199

  Fly   143 KRQRVADLLLAVGLRDAAHTRIQQLSGGERKRLSLAEELITDPIFLFCDEPTTGLDSFSAYSVIK 207
            :|:.|.::|.|:||.:.|.||...||||:||||::|.||:.:|..:|.||||:||||.|.:.|:.
Zfish   200 RREMVREILTALGLLECAKTRTSHLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSSSCFQVVS 264

  Fly   208 TLRHLCTRRRIAKHSLNQVYGEDSFETPSGESSASGSGSKSIEMEVVAESHESLLQTMRELPALG 272
            .::.|                            |.|.
Zfish   265 LMKAL----------------------------AQGG---------------------------- 273

  Fly   273 VLSNSPNGTHKKAAICSIHQPTSDIFELFTHIILMDGGRIVYQGRTEQAAKFFTDLGYELPLNCN 337
                       :..||:||||::.:||||..:.::..|:.:|:|:......:..|||...|...|
Zfish   274 -----------RTVICTIHQPSAKVFELFDKLYVLSQGQCIYRGKVSSLIPYLRDLGLSCPTYHN 327

  Fly   338 PADFYLKTLADKEGKENAGAVLRAKYEHETDGLY----------------------SGSWLLARS 380
            ||||.::..:.:.|.:.| .:::|..||:.:..|                      |.|.....|
Zfish   328 PADFIMEVASGEYGDQTA-RLVKAVQEHKCEKDYKTEMNGNGVHNPFLWHRPSDEESSSSEGCHS 391

  Fly   381 YSGDYLKHVQNFKKIRWIYQVYLLMVRFMTEDLRNIRSGLIAFGFFMITAVTLSLMYSGIGGLTQ 445
            :|...|.            |..:|..|.....:|:.....:.....:...:.:.|:|.|||...:
Zfish   392 FSASCLT------------QFCILFKRTFLSIMRDSVLTHLRIMSHLGIGILIGLLYLGIGNEAK 444

  Fly   446 RTVQDVGGSIFMLSNEMIFTFSYGVTYIFPAALPIIRREVGEGTYSLSAYYVALVLSFVPVAFFK 510
            :.:.: .|.:|.....::|.........||..:.:..||.....|||.|||:|..::.||.
Zfish   445 KVLSN-SGFLFFSMLFLMFAALMPTVLTFPLEMGVFLREHLNYWYSLKAYYLAKTMADVPF---- 504

  Fly   511 GYVFLSVIYASIYY--------TRGFLLYLSMGFLMSLSAVAAVGYGVFLSSLFESDKMASECAA 567
             .:...|.|.||.|        ...|:|:|::|.|.||   .|...|:.:.:...|.::|:....
Zfish   505 -QIVFPVAYCSIVYWMTSQPSDAVRFILFLALGTLTSL---VAQSLGLLIGAASTSLQVATFVGP 565

  Fly   568 PFDLIFLIFGGTYMNVDTVP----GLKYLSLFFYSNEALMYKFW-IDIDNIDCPVNEDHPC-IKT 626
            ...:..|:|.|.:::.||:|    .:.|:|...|..|.::...: :|.:::.|  ::|..| .:.
Zfish   566 VTAIPVLLFSGFFVSFDTIPKYLQWISYISYVRYGFEGVILSIYGLDREDLHC--DKDETCHFQK 628

  Fly   627 GVEVLQQGSYRNADYTYWLDCFSLVVVAVIFHIVSFGLVRRYIHR 671
            ...:|::....:|  ..::|   .:|:.:.|  :|..|:..::.|
Zfish   629 SEAILKELDVEDA--KLYMD---FIVLGIFF--ISLRLIAYFVLR 666

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bw	NP_001286769.1	P-loop_NTPase	31..316	CDD:304359	74/284 (26%)
		3a01204	40..673	CDD:273361	157/668 (24%)
		ABC2_membrane	404..604	CDD:279410	50/211 (24%)
abcg1	NP_001103924.1	3a01204	67..673	CDD:273361	165/695 (24%)
		ABCG_EPDR	81..306	CDD:213180	80/301 (27%)
		ABC2_membrane	403..605	CDD:279410	50/210 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820