DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bw and E23

DIOPT Version :9

Sequence 1:	NP_001286769.1	Gene:	bw / 37724	FlyBaseID:	FBgn0000241	Length:	675	Species:	Drosophila melanogaster
Sequence 2:	NP_524648.3	Gene:	E23 / 43895	FlyBaseID:	FBgn0020445	Length:	1017	Species:	Drosophila melanogaster

Alignment Length:	775	Identity:	173/775 - (22%)
Similarity:	296/775 - (38%)	Gaps:	223/775 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SSGQGGPSLCLEWKQLNYYVPDQEQSNYSFWNECRKKRELRILQDASGHMKTGDLIAILGGSGAG 71
            |..|...||.|.::.||..                 ..|.:||.|.||.:...:::||:|.||:|
  Fly   343 SQNQPQHSLQLTFQNLNVL-----------------HNERQILSDVSGFVSPCEVLAIMGPSGSG 390

  Fly    72 KTTLLAAISQRLRGNLTGDVVLNGMAMERHQMTRISSFLPQFEINVKTFTAYEHLYFMSHFKMHR 136
            |||||..:|.: |...:|.|.||...:.:....|| .::.|.||.....|..|.:.:.:..::..
  Fly   391 KTTLLDCLSGQ-RHIDSGSVFLNREPLTKKWRRRI-GYVLQEEIFFPQLTLRETVVYTALLRLPE 453

  Fly   137 RTTKAEKRQRVADLLLAVGLRDAAHTRI-----QQLSGGERKRLSLAEELITDPIFLFCDEPTTG 196
            ...:|||.::|..:|.|:.|.....|:.     :.|||||:||.::|.||:|:|:.:..||||:|
  Fly   454 SMPRAEKMRQVDHILEALELGCCQQTKFGDYLNRGLSGGEKKRANIACELLTNPLLMLLDEPTSG 518

  Fly   197 LDSFSAYSVIKTLRHLCTRRRIAKHSLNQVYGEDSFETPSGESSASGSGSKSIEMEVVAESHESL 261
            |||.||.|::|.|:.               |.:
  Fly   519 LDSHSAISLMKVLKR---------------YAQ-------------------------------- 536

  Fly   262 LQTMRELPALGVLSNSPNGTHKKAAICSIHQPTSDIFELFTHIILMDGGRIVYQGRTEQAAKFFT 326
                               ..:|..:.|:|||:|.:|.:|..::|:..||..|.|..:...:.|.
  Fly   537 -------------------LEQKTIVISVHQPSSQMFHMFDKLLLLHQGRTAYFGDVQNIYRHFE 582

  Fly   327 DLGYELPLNCNPADFYLKTL------------ADKE-------------------------GKEN 354
            |:|..:..:.|||||.|:.|            |.||                         ||:.
  Fly   583 DIGVTIKPHYNPADFVLEQLKSHPDIREKLFIAAKESHGNYLNRNCITSSHHNQVSVSGAKGKKQ 647

  Fly   355 AGAVL------------RAKYEHETDGLYSGS----------------WLLA------------- 378
            |.::|            ..::.|:.:.|:..|                |..|
  Fly   648 ADSILIDDIINNYYNQRSNRHHHQYENLHHTSNGCRVEEDEEAAQHLVWCAADSQSNFSSCASSD 712

  Fly   379 -RSYSG----------DYLKHVQNFKKIRWIYQVYLLMVRFMTEDLRNIRSG----LIAFGFFMI 428
             .|||.          |:|.:..:|.            .:|.....||.|..    |....:|.
  Fly   713 CHSYSAGSGPGHSADDDWLSYPTSFH------------TQFCVLSSRNFREAKPRMLSKLNWFQ- 764

  Fly   429 TAVTLSLMYSGIGGLTQRT---VQDVGGSIFMLSNEMIFTFSYGVTYIFPAALPIIRREVGEGTY 490
             .:.|:||...|.....||   :.|:.|.:|......:....:|....||:...::.:|...|.|
  Fly   765 -TIGLALMAGAIWFQLPRTEEFLHDLQGWMFFSQTYWMLFALFGALNSFPSEREVVSKERRSGAY 828

  Fly   491 SLSAYYVALVLSFVPVAFFKGYVFLSVIYASIYYTRGFLLYLSMGFLMSLSAVAAVGYGVFLSSL 555
            .|||||:|.:.:.:|:......|:|.:.|..:..|...|.:|.:.||: ::.:.|...|.|:.:.
  Fly   829 RLSAYYLAKMCAELPLVITLPTVYLMISYPMLGCTSLKLFFLMLIFLL-INTIVAQSVGFFIGAC 892

  Fly   556 FESDKMASECAAPFDLIFLIFGGTYMNVDTVPGL---KYLSLFFYSNEALMYKFWIDIDNIDCPV 617
            .....::...:|.:.|...:||| |::.....||   :|.|:..|:.:.:....:.:...|.|..
  Fly   893 CMDMNVSITLSALYTLATQLFGG-YLSSRIPEGLSWIRYTSMIHYAYQNMQILEFREGAAIGCGS 956

  Fly   618 NEDHPCIKTGVEVLQQGS-----------YRNADYTYWLDCFSLVVVAVIFHIVSFGLVR 666
            ...:       |:.:|.|           .:|:....||:...|::..::|..:.:.::|
  Fly   957 PSSY-------EICKQQSTEFIPYEEILKAQNSTSPLWLNTLILMMFFLVFRCLGYAVLR 1009

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bw	NP_001286769.1	P-loop_NTPase	31..316	CDD:304359	76/289 (26%)
		3a01204	40..673	CDD:273361	166/742 (22%)
		ABC2_membrane	404..604	CDD:279410	50/209 (24%)
E23	NP_524648.3	ABCG_EPDR	350..572	CDD:213180	81/306 (26%)
		3a01204	363..1009	CDD:273361	165/736 (22%)
		ABC2_membrane	744..943	CDD:279410	49/202 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48041
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.010