DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bw and Abca14

DIOPT Version :9

Sequence 1:	NP_001286769.1	Gene:	bw / 37724	FlyBaseID:	FBgn0000241	Length:	675	Species:	Drosophila melanogaster
Sequence 2:	XP_038957098.1	Gene:	Abca14 / 365362	RGDID:	1561491	Length:	1691	Species:	Rattus norvegicus

Alignment Length:	792	Identity:	175/792 - (22%)
Similarity:	299/792 - (37%)	Gaps:	222/792 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 GGPSLCLEWKQLNYYVP---------DQE---QSNYSFWNECRKKRELRILQDASGHMKTGDLIA 63
            |.|:|..|..|::...|         |.|   |..:.:.....|...|..::|.|.::..|.:..
  Rat   500 GEPALSREESQVSDLPPSDFMEPEPVDLEAGIQIQHLYKEFTLKNSTLMAVKDLSLNLYEGQITV 564

  Fly    64 ILGGSGAGKTTLLAAISQRLRGNLTGDVVLNG--MAMERHQMTRISSFLPQFEINVKTFTAYEHL 126
            :||.:||||||.|:.:: .|.....|.|.::|  ::.:..|:.:.....||.::.....|..|||
  Rat   565 LLGHNGAGKTTTLSILT-GLYLPTKGKVYISGYDISSDMVQVRKSLGLCPQDDLLFPLLTVSEHL 628

  Fly   127 YFMSHFKMHRRTTKAEKRQRVADLLLAVGLRDAAHTRIQQLSGGERKRLSLAEELITDPIFLFCD 191
            ||....|....|.:..:..|   :|.:.||...::|..:.||||.:::||:...||.|...:..|
  Rat   629 YFYCVIKGISSTNRPREIHR---MLTSFGLLQKSNTMSKDLSGGMKRKLSIIIALIGDTKVVILD 690

  Fly   192 EPTTGLDSFSAYSVIKTLRHLCTRRRI--AKHSLNQVYGEDSFETPSGESSASGSGSKSIEMEVV 254
            |||:|:|..|..::...|:|....|.|  ..|.::             |:...|.....:.|.|:
  Rat   691 EPTSGMDPVSRRAIWDLLQHYKKDRTILLTTHHMD-------------EADVLGDRIAILVMGVL 742

  Fly   255 AESHESLLQTMRELPALG---VLSNSPNGTHKK-AAICSIHQPTSDIFELFTHIILMDGGRIVYQ 315
            .....||.  :::|..:|   |:..:|:....| :.:...:.||:   |:.|: :..:...|:.:
  Rat   743 KCCGSSLF--LKKLYGVGYHLVIVKTPDSDDGKISQLIKNYIPTA---EMETN-VAAELSFILPK 801

  Fly   316 GRTEQAAKFFTDL----------GYELPLN---------CNPADFYLKT----------LADKEG 351
            ..|.:.|:.||||          |:.:.:.         .|.||..|.|          .:..|.
  Rat   802 EHTHRFAELFTDLEERQEELGISGFGVSMTTMDEVFFKVSNLADLKLNTEIAQSASTVNPSTSEN 866

  Fly   352 KENAGA---VLRAKYE-HETDGLYSGSW-LLARSYSGDYLKHVQNFKKIRWIYQVYLLMVRFMTE 411
            .||...   ..|:.|. ..:|..::..| |..:.:...::|.|. |....|    .||:::.:.
  Rat   867 NENMNVPRNFERSGYSGRYSDSSFNAGWPLYMQQFRAMFIKRVM-FSWRNW----KLLLLQLLA- 925

  Fly   412 DLRNIRSGLI-AFGF--------------FMITAVTLSLMYSGIGGLTQR--------------T 447
             |:.:...|| ..||              :..|.|..|:  ||...|||:              .
  Rat   926 -LQGLTYVLIKGIGFSVPKEPARVMDLEQYGETTVPFSV--SGDPPLTQKLTKNLEIMLKDKKQK 987

  Fly   448 VQDVGGSI--FMLSNE-----MIFTFSYGVTYIFPAALPIIRREVGEGTYSL----SAYYVA-LV 500
            |.:|.|.:  ::|:|:     .|..||..||          |:   |.|::.    .||:.: |.
  Rat   988 VHEVQGGVQDYLLTNKDCIYSCIVAFSLDVT----------RK---EKTFTFWFNNEAYHASPLS 1039

  Fly   501 LSFV----------------------PVAFFKG----------YVFLSVIYASIYYTRGFLLYLS 533
            ||.:                      |..|.||          .:..::::....:|.||.|
  Rat  1040 LSILDNIIFKYLSGPDATITVSNKPQPQPFTKGRSEERSASGIQIVFNLLFGMSIFTSGFCL--- 1101

  Fly   534 MGFLMSLSAVAAVGYGVFLSSLFESDKMASECAAPFDLI---------FLIFGGT--------YM 581
               :.....|:...:..|:|.::..:...|  |..:|||         .|:|..|        |.
  Rat  1102 ---MTVTERVSKAKHIQFVSGVYTLNFWLS--ALLWDLIIHFVACVLLLLVFLYTDVHILLENYN 1161

  Fly   582 NVDTVPGLKYLSLFFYSNEALMY--KFWIDIDNIDCPVNEDHPCIKTGVEVLQQGSYRNADYTYW 644
            .:||   :..|.||.:|....:|  .||.:        |..:..||..|            :.:.
  Rat  1162 FLDT---MLILMLFGWSIIPFIYLLSFWYN--------NSTNAYIKIFV------------FNHC 1203

  Fly   645 LDCFSLVVVAVI 656
            |...|::|.||:
  Rat  1204 LGFMSIIVDAVV 1215

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bw	NP_001286769.1	P-loop_NTPase	31..316	CDD:304359	72/292 (25%)
		3a01204	40..673	CDD:273361	166/751 (22%)
		ABC2_membrane	404..604	CDD:279410	58/289 (20%)
Abca14	XP_038957098.1	rim_protein	<100..1681	CDD:130324	175/792 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000