DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bw and Abca4

DIOPT Version :9

Sequence 1:	NP_001286769.1	Gene:	bw / 37724	FlyBaseID:	FBgn0000241	Length:	675	Species:	Drosophila melanogaster
Sequence 2:	NP_001101191.1	Gene:	Abca4 / 310836	RGDID:	1309445	Length:	2290	Species:	Rattus norvegicus

Alignment Length:	396	Identity:	90/396 - (22%)
Similarity:	145/396 - (36%)	Gaps:	124/396 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 GDLIAILGGSGAGKTTLLAAISQRLRGNLT---GDVVLNGMAMERHQMTRIS------SFLPQFE 114
            |:...:||.:||||||..    :.|.|:.|   ||..:.|.::    :|.||      .:.|||:
  Rat  1942 GECFGLLGVNGAGKTTTF----KMLTGDTTVTSGDATIAGKSI----LTNISDVHQNMGYCPQFD 1998

  Fly   115 INVKTFTAYEHLYFMSHFKMHRRTTKAEKRQRVADL-LLAVGLRDAAHTRIQQLSGGERKRLSLA 178
            ......|..||||..:..    |...:::.::||:. :.::||...|.......|||.:::||.|
  Rat  1999 AIDDLLTGREHLYLYARL----RGVPSKEIEKVANWGIQSLGLSLYADRLAGTYSGGNKRKLSTA 2059

  Fly   179 EELITDPIFLFCDEPTTGLDSFSA----YSVIKTLRH----------------LCTRRRIAKHSL 223
            ..|...|..|..||||||:|..:.    .:::..:|.                ||||..|.....
  Rat  2060 IALTGCPPLLLLDEPTTGMDPQARRMLWNTIVNIIRQGRAVVLTSHSMEECEALCTRLAIMVKGT 2124

  Fly   224 NQVYGE---------DSF------ETPSG---------ESSASGSGSKSIEMEVVAESHESLLQT 264
            .|..|.         |.:      ::|..         |....|:...|::    .|.|.|:||
  Rat  2125 FQCMGTIQHLKYKFGDGYIVTMKIKSPKDDLLPDLNPVEQFFQGNFPGSVQ----RERHHSMLQ- 2184

  Fly   265 MRELPALGVLSNSPNGTHKKAAICSIHQPTSDIFELFTHIILMDGGRIVYQGRTEQA-------- 321
                                     ...|:|.:..:|..:|......::.:....|.
  Rat  2185 -------------------------FQVPSSSLARIFQLLISHKDSLLIEEYSVTQTTLDQVFVN 2224

  Fly   322 -AKFFTDLGYELPLNCNPADFYLKTLADKEGKENAGAVLRAKYEHETDGLYSGSWLLARSYSGDY 385
             ||..|:. |:|||:                ...|||..:||.|.::..|.:...|.|.  |.::
  Rat  2225 FAKQQTET-YDLPLH----------------PRAAGASWQAKLEGKSGRLETQEPLPAG--SSEH 2270

  Fly   386 LKHVQN 391
            |.::.|
  Rat  2271 LANINN 2276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bw	NP_001286769.1	P-loop_NTPase	31..316	CDD:304359	70/310 (23%)
		3a01204	40..673	CDD:273361	90/396 (23%)
		ABC2_membrane	404..604	CDD:279410
Abca4	NP_001101191.1	rim_protein	1..2249	CDD:130324	81/365 (22%)
		ABC_subfamily_A	907..1126	CDD:213230
		ABC_subfamily_A	1915..2135	CDD:213230	56/204 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000