DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bw and Abca12

DIOPT Version :9

Sequence 1:	NP_001286769.1	Gene:	bw / 37724	FlyBaseID:	FBgn0000241	Length:	675	Species:	Drosophila melanogaster
Sequence 2:	XP_237242.6	Gene:	Abca12 / 301482	RGDID:	1304586	Length:	2595	Species:	Rattus norvegicus

Alignment Length:	815	Identity:	145/815 - (17%)
Similarity:	245/815 - (30%)	Gaps:	335/815 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 GDLIAILGGSGAGKTTLLAAISQRLRGNLTGDVVLNG--MAMERHQMTRISSFLPQFEINVKTFT 121
            |.:.::||.:||||||.::.:: .|.|...|.:.:.|  :..:.:.:.:......|.::.....|
  Rat  1371 GHITSLLGPNGAGKTTTISMLT-GLFGATAGTIFVYGKDIKTDLNTVRKNMGVCMQHDVLFSYLT 1434

  Fly   122 AYEHLYFMSHFKMHRRTTKAEKRQRVADLLLAVGLRDAAHTRIQQLSGGERKRLSLAEELITDPI 186
            ..|||......|: ...||.:..:.|...|...||....|.|:..||||.:::||::..||....
  Rat  1435 TKEHLLLYGSIKV-PHWTKKQLHEEVKRTLKDTGLYSHRHKRVGTLSGGMKRKLSISIALIGGSR 1498

  Fly   187 FLFCDEPTTGLDSFS-------------AYSVIKTLRHL--------------------C----- 213
            .:..|||:||:|..|             |.::|.:..||                    |
  Rat  1499 VVILDEPSTGVDPCSRRSIWDVISKNKTARTIILSTHHLDEAEVLSDRIAFLEQGGLRCCGSPFY 1563

  Fly   214 -------------TRRR------------------IAKHSLNQVY------GEDSFETPSGESSA 241
                         |:::                  |..| |.:.|      ||..:..|...:..
  Rat  1564 LKEAFGDGYHLTLTKKKSPNLDTNAICDTVAVTAMIQSH-LPEAYLKEDIGGELVYVLPPFSTKV 1627

  Fly   242 SGS-----------------GSKSIEMEVVAESHESLLQ--------TMRELPALGVLSNSPNGT 281
            ||:                 |...|....|.|...:|.:        ::..|....|.:.|.|||
  Rat  1628 SGAYLSLLRALDKGMGKLNIGCYGISDTTVEEVFLNLTKDSQKCGNMSLEHLTQRKVGNPSANGT 1692

  Fly   282 H--KKAAICSIHQPTSDIFELFTHIILMDGGRIV------------------YQGRTEQAAKFFT 326
            .  ...::.|.:....| .::.|....:||..::                  ::|...|..
  Rat  1693 STPDDLSVSSSNFTDRD-DKVLTRSERLDGFGLLLKKIMAILIKRFHHTRRNWKGLIAQVV---- 1752

  Fly   327 DLGYELPLNCNPADFYLKTLADKEGK------------ENAGAVLRAKYEHETDGLYSGSWLL-- 377
                 ||:........|.||.|....            .:......|.::..|:.|.|..|..
  Rat  1753 -----LPIVFVATAMGLGTLRDSSNSYPELLISPSIYGNSEQTAFYANFDPSTNALVSALWNFPG 1812

  Fly   378 -----------------------------------------------------ARSYSGDYL--- 386
                                                                 .|:||...:
  Rat  1813 IDNVCLNTSDSQCLKKDNLGKWNTSGEAIDNFGVCSCSDNVQECPKFNYSPPHRRTYSSQVIYNL 1877

  Fly   387 --KHVQNF----------KKI-RWIYQVYLLMVRFMTEDLRNIRSGLIAFGFFMITAVTLS---- 434
              ||::|:          |:. .|.:.:.|      |.|||           |.:|||.::
  Rat  1878 TGKHMENYLISTANHFVQKRYGGWSFGMKL------TNDLR-----------FDVTAVPVNRTLA 1925

  Fly   435 --------------------------------------LMYS----GIGGLTQRTVQ---DVGGS 454
                                                  :|||    |:....|.|:.   |:..:
  Rat  1926 KVWYDPEGYHSLPAYLNSLNNFLLRVNMSEYDAARHGIIMYSHPYPGVQDQEQATISSLIDILVA 1990

  Fly   455 IFMLSNEMIFTFSYGVTYIFPAALPIIRRE------------VGEGTYSLSAYYVALVLSFVPVA 507
            :.:|....:.|.|: |||       |:|..            :|...|.::.:...:|...||||
  Rat  1991 LSILMGYSVTTASF-VTY-------IVREHQTKAKQLQHISGIGVTCYWVTNFIYDMVFYLVPVA 2047

  Fly   508 F-------FK--------------------GYVFLSVIY--ASIYYTRG--FLLYLSMGFLMSLS 541
            |       ||                    ||...|.:|  |.:::..|  |:.|:.:.....::
  Rat  2048 FSIGVIAIFKLPAFYSGNNLGAVSLLLLLFGYATFSWMYLLAGLFHETGMAFITYVCVNLFFGIN 2112

  Fly   542 AVAAVGYGVFLSSLFESDKMASECAAPFDLIFLIF 576
            ::.::....|||....:|......:.....|||||
  Rat  2113 SIVSLSVVYFLSKEKPNDPTLELISETLKRIFLIF 2147

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bw	NP_001286769.1	P-loop_NTPase	31..316	CDD:304359	73/378 (19%)
		3a01204	40..673	CDD:273361	145/815 (18%)
		ABC2_membrane	404..604	CDD:279410	50/265 (19%)
Abca12	XP_237242.6	ABC2_membrane_3	<1006..1267	CDD:289468
		NosY	<1108..1269	CDD:224196
		ZnuC	1346..1570	CDD:224046	47/200 (24%)
		ABC_subfamily_A	1350..1565	CDD:213230	47/195 (24%)
		ABC2_membrane_3	<1913..2174	CDD:289468	46/243 (19%)
		CcmA	2253..2567	CDD:224054
		ABC_subfamily_A	2254..2477	CDD:213230
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000