DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bw and Abcg5

DIOPT Version :9

Sequence 1:	NP_001286769.1	Gene:	bw / 37724	FlyBaseID:	FBgn0000241	Length:	675	Species:	Drosophila melanogaster
Sequence 2:	NP_114090.1	Gene:	Abcg5 / 27409	MGIID:	1351659	Length:	652	Species:	Mus musculus

Alignment Length:	703	Identity:	180/703 - (25%)
Similarity:	289/703 - (41%)	Gaps:	177/703 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 FWN--ECRKKRELRILQDASGHMKTGDLIAILGGSGAGKTTLLAAISQRLR--GNLTGDVVLNGM 96
            :||  .|::|.:.:||:|.|.::::|.::.|||.||:||||||.|||.|||  |.|.|:|.:||.
Mouse    55 WWNIKSCQQKWDRQILKDVSLYIESGQIMCILGSSGSGKTTLLDAISGRLRRTGTLEGEVFVNGC 119

  Fly    97 AMERHQMTRISSFLPQFEINVKTFTAYEHLYFMSHFKMHRRTTKAEKRQRVADLLLAVGLRDAAH 161
            .:.|.|.....|::.|.::.:.:.|..|.|.:.:...:.|.:.....: :|..::..:.|...|.
Mouse   120 ELRRDQFQDCFSYVLQSDVFLSSLTVRETLRYTAMLALCRSSADFYNK-KVEAVMTELSLSHVAD 183

  Fly   162 TRIQQ-----LSGGERKRLSLAEELITDPIFLFCDEPTTGLDSFSAYSVIKTLRHLCTRRRIAKH 221
            ..|..     :|.|||:|:|:|.:|:.||..:..||||||||..:|..::..|..|..|.||
Mouse   184 QMIGSYNFGGISSGERRRVSIAAQLLQDPKVMMLDEPTTGLDCMTANQIVLLLAELARRDRI--- 245

  Fly   222 SLNQVYGEDSFETPSGESSASGSGSKSIEMEVVAESHESLLQTMRELPALGVLSNSPNGTHKKAA 286
                                                                            .
Mouse   246 ----------------------------------------------------------------V 246

  Fly   287 ICSIHQPTSDIFELFTHIILMDGGRIVYQGRTEQAAKFFTDLGYELPLNCNPADFYLK-TLADKE 350
            |.:||||.|::|:.|..|.::..|.:|:.|..|:...||.:.||..|.:.||.|||:. |..|.:
Mouse   247 IVTIHQPRSELFQHFDKIAILTYGELVFCGTPEEMLGFFNNCGYPCPEHSNPFDFYMDLTSVDTQ 311

  Fly   351 GKENAGAVLRAKYEHETDGLYSGSWLLARSY--SGDYLKHVQNFKKIRWIYQVYLLMVRFMTED- 412
            .:|.         |.||   |....:|..::  |..|.|.::|.::.|  |...|..|.|.|:|
Mouse   312 SRER---------EIET---YKRVQMLECAFKESDIYHKILENIERAR--YLKTLPTVPFKTKDP 362

  Fly   413 ----------LRNIRSGL--------------IAFGFFMITAVTLSLMYSGIGGLTQRTVQDVGG 453
                      ||.:...|              :..|.|:|..: |.:..:.:.|    .|||..|
Mouse   363 PGMFGKLGVLLRRVTRNLMRNKQAVIMRLVQNLIMGLFLIFYL-LRVQNNTLKG----AVQDRVG 422

  Fly   454 SIFMLSNEMIFTFSYGVTYIFPAALPIIRREVGEGTYSLSAYYVALVLSFVPVAFFKGYVFLSVI 518
            .::.|.....:|.......:||....:..:|..:|.|......:|.||..:|.:     |..:||
Mouse   423 LLYQLVGATPYTGMLNAVNLFPMLRAVSDQESQDGLYHKWQMLLAYVLHVLPFS-----VIATVI 482

  Fly   519 YASI-YYTRGFLLYLSMGFLMSLSAVAAVGY-----------GVFLS----SLFESDKMASECAA 567
            ::|: |:|.|  ||         ..||..||           |.||:    .:.::..:.:...|
Mouse   483 FSSVCYWTLG--LY---------PEVARFGYFSAALLAPHLIGEFLTLVLLGIVQNPNIVNSIVA 536

  Fly   568 PFDLIFLIFG-GTYMNVDTVP-GLKYLSLFF---YSNEALMYKFWIDIDNIDCPVNE----DHP- 622
            ...:..|:.| |...|:..:| .||.|..|.   |..|.|:...:..: |..|..:.    :||
Mouse   537 LLSISGLLIGSGFIRNIQEMPIPLKILGYFTFQKYCCEILVVNEFYGL-NFTCGGSNTSMLNHPM 600

  Fly   623 -CIKTGVEVLQQ-----GSYRNADYTYWLDCFSLVVVAVIFHIVSFGLVRRYI 669
             .|..||:.:::     .|...|::   |..:..:...||..||.| .||.|:
Mouse   601 CAITQGVQFIEKTCPGATSRFTANF---LILYGFIPALVILGIVIF-KVRDYL 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bw	NP_001286769.1	P-loop_NTPase	31..316	CDD:304359	79/288 (27%)
		3a01204	40..673	CDD:273361	178/697 (26%)
		ABC2_membrane	404..604	CDD:279410	56/245 (23%)
Abcg5	NP_114090.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		ABCG_White	50..276	CDD:213201	79/288 (27%)
		3a01204	61..646	CDD:273361	175/692 (25%)
		ABC2_membrane	372..579	CDD:279410	52/227 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48041
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920