DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bw and Abca7

DIOPT Version :9

Sequence 1:	NP_001286769.1	Gene:	bw / 37724	FlyBaseID:	FBgn0000241	Length:	675	Species:	Drosophila melanogaster
Sequence 2:	NP_001334010.1	Gene:	Abca7 / 27403	MGIID:	1351646	Length:	2167	Species:	Mus musculus

Alignment Length:	361	Identity:	84/361 - (23%)
Similarity:	138/361 - (38%)	Gaps:	81/361 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 GDLIAILGGSGAGKTTLLAAISQRL-----RGNLTGDVVLNGMAMERHQMTRISSFLPQFEINVK 118
            |.:.|.||.:||||||.|:.:|...     ..::.|..|...||..|..:    ...||:.:...
Mouse   831 GHITAFLGHNGAGKTTTLSILSGLFPPSSGSASILGHDVQTNMAAIRPHL----GICPQYNVLFD 891

  Fly   119 TFTAYEHLYFMSHFKMHRRTTKAEKRQRVADLLLAVGLRDAAHTRIQQLSGGERKRLSLAEELIT 183
            ..|..||::|....|.........:|:|   |:..|||.....|:.:.||||.:::||:|...:.
Mouse   892 MLTVEEHVWFYGRLKGVSAAAMGPERER---LIRDVGLTLKRDTQTRHLSGGMQRKLSVAIAFVG 953

  Fly   184 DPIFLFCDEPTTGLDSFS-------------AYSVIKTLRHL--------------------C-- 213
            ....:..||||.|:|..|             ..::|.:..||                    |
Mouse   954 GSRVVIMDEPTAGVDPASRRGIWELLLKYREGRTLILSTHHLDEAELLGDRVAMVAGGSLCCCGS 1018

  Fly   214 ---TRRRI----------AKHSLNQVYGEDSFETPSGESSASGSGSKSIEMEVVAESHESLLQTM 265
               .||.:          :..||.....:...|.|..|..:.|:|..|........|.:|
Mouse  1019 PLFLRRHLGCGYYLTLVKSSQSLVTHDAKGDSEDPRREKKSDGNGRTSDTAFTRGTSDKS----- 1078

  Fly   266 RELPALGVLSNSPNGTHKKAAICSIHQPTSDIFELFTHIILMDGGRIVYQGRTEQA-AKFFTDLG 329
            .:.||.|.:..:|: |.:...:...|.|.:.:.|...|.:|:   .:.|.|..:.: |..|.:|.
Mouse  1079 NQAPAPGAVPITPS-TARILELVQQHVPGAQLVEDLPHELLL---VLPYAGALDGSFAMVFQELD 1139

  Fly   330 YELPL---------NCNPADFYLKTLAD--KEGKEN 354
            .:|.|         :.|..:.:||.:.|  :||.::
Mouse  1140 QQLELLGLTGYGISDTNLEEIFLKVVEDAHREGGDS 1175

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bw	NP_001286769.1	P-loop_NTPase	31..316	CDD:304359	72/309 (23%)
		3a01204	40..673	CDD:273361	84/361 (23%)
		ABC2_membrane	404..604	CDD:279410
Abca7	NP_001334010.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1042..1088		11/50 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1172..1192		1/4 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2126..2167
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000