DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bw and Abcg2

DIOPT Version :9

Sequence 1:	NP_001286769.1	Gene:	bw / 37724	FlyBaseID:	FBgn0000241	Length:	675	Species:	Drosophila melanogaster
Sequence 2:	NP_001342406.1	Gene:	Abcg2 / 26357	MGIID:	1347061	Length:	657	Species:	Mus musculus

Alignment Length:	686	Identity:	170/686 - (24%)
Similarity:	284/686 - (41%)	Gaps:	157/686 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 RKKRELRILQDASGHMKTGDLIAILGGSGAGKTTLLAAISQRL--RGNLTGDVVLNGMAMERHQM 103
            ||..|..||.|.:|.||.| |.||||.:|.||::||..::.|.  :| |:|||::||.....| .
Mouse    55 RKTVEKEILSDINGIMKPG-LNAILGPTGGGKSSLLDVLAARKDPKG-LSGDVLINGAPQPAH-F 116

  Fly   104 TRISSFLPQFEINVKTFTAYEHLYFMSHFKMHRRTTKAEKRQRVADLLLAVGLRDAAHTR----- 163
            ...|.::.|.::.:.|.|..|:|.|.:..::.......||.:|:..::..:||...|.::
Mouse   117 KCCSGYVVQDDVVMGTLTVRENLQFSAALRLPTTMKNHEKNERINTIIKELGLEKVADSKVGTQF 181

  Fly   164 IQQLSGGERKRLSLAEELITDPIFLFCDEPTTGLDSFSAYSVIKTLRHLCTRRRIAKHSLNQVYG 228
            |:.:|||||||.|:..||||||..||.|||||||||.:|.:|:..|      :|::|..
Mouse   182 IRGISGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLL------KRMSKQG------ 234

  Fly   229 EDSFETPSGESSASGSGSKSIEMEVVAESHESLLQTMRELPALGVLSNSPNGTHKKAAICSIHQP 293
                                                                   :..|.|||||
Mouse   235 -------------------------------------------------------RTIIFSIHQP 244

  Fly   294 TSDIFELFTHIILMDGGRIVYQGRTEQAAKFFTDLGYEL-PLNCNPADFYLKTLADKEGKENAGA 357
            ...||:||..:.|:..|::|:.|..::|.::|...||.. |.| |||||:|..:   .|..:|..
Mouse   245 RYSIFKLFDSLTLLASGKLVFHGPAQKALEYFASAGYHCEPYN-NPADFFLDVI---NGDSSAVM 305

  Fly   358 VLRAKYEHE---TDGLYSGSWLLARSYSGDYL---------------------KHVQNFK----- 393
            :.|.:.::|   |:....|...:..:.|..|:                     |....||
Mouse   306 LNREEQDNEANKTEEPSKGEKPVIENLSEFYINSAIYGETKAELDQLPGAQEKKGTSAFKEPVYV 370

  Fly   394 -----KIRWIYQVYLLMVRFMTEDLRNIRSGL------IAFGFFMITAVTLSLMYSGIGGLTQRT 447
                 ::|||.:      |.....|.|.::.:      :..| .:|.|:...|.|...|
Mouse   371 TSFCHQLRWIAR------RSFKNLLGNPQASVAQLIVTVILG-LIIGAIYFDLKYDAAG------ 422

  Fly   448 VQDVGGSIFMLSNEMIFTFSYGVTYIFPAALPIIRREVGEGTYSLSAYYVALVLS-FVPVAFFKG 511
            :|:..|.:|.|:....|: |.....:|.....:...|...|.|.:|:|:...|:| .:|:.|...
Mouse   423 MQNRAGVLFFLTTNQCFS-SVSAVELFVVEKKLFIHEYISGYYRVSSYFFGKVMSDLLPMRFLPS 486

  Fly   512 YVFLSVIYASIYYTRGFLLYLSMGFLMSLSAVAAVGYGVFLSSLFESDKMASECAAPFDLIF--- 573
            .:|..::|..:...:....:..|.|.:.:.|..|....:.:::   ...:.|.......:.|
Mouse   487 VIFTCILYFMLGLKKTVDAFFIMMFTLIMVAYTASSMALAIAT---GQSVVSVATLLMTIAFVFM 548

  Fly   574 LIFGGTYMNVDTV-PGLKYLSLFF---YSNEALMYKFWIDIDNIDCP---VNEDHPCIK-----T 626
            ::|.|..:|:.|: |.|.:|..|.   |...||.|..::..:  .||   |.::..|:.     |
Mouse   549 MLFSGLLVNLRTIGPWLSWLQYFSIPRYGFTALQYNEFLGQE--FCPGFNVTDNSTCVNSYAICT 611

  Fly   627 GVEVLQQGSYRNADYTYWLDCFSLVVVAVIFHIVSF 662
            |.|.|.......:.:..|.:..:|..:.:||..:::
Mouse   612 GNEYLINQGIELSPWGLWKNHVALACMIIIFLTIAY 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bw	NP_001286769.1	P-loop_NTPase	31..316	CDD:304359	86/281 (31%)
		3a01204	40..673	CDD:273361	170/686 (25%)
		ABC2_membrane	404..604	CDD:279410	44/213 (21%)
Abcg2	NP_001342406.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
Abcg2	NP_001342406.1	3a01204	46..651	CDD:273361	170/686 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820