DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bw and wht-6

DIOPT Version :9

Sequence 1:	NP_001286769.1	Gene:	bw / 37724	FlyBaseID:	FBgn0000241	Length:	675	Species:	Drosophila melanogaster
Sequence 2:	NP_498425.2	Gene:	wht-6 / 188911	WormBaseID:	WBGene00007060	Length:	613	Species:	Caenorhabditis elegans

Alignment Length:	667	Identity:	173/667 - (25%)
Similarity:	304/667 - (45%)	Gaps:	130/667 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 WNECR----KKRELRILQDASGHMKTGDLIAILGGSGAGKTTLLAAISQR-LRGNLT-GDVVLNG 95
            ||...    |::.| :|::.||:.|:|:|:|::|.|||||||||..:..| |:|..| |.:.:||
Worm    36 WNNITVTTIKEKRL-LLKNVSGYAKSGELLALMGASGAGKTTLLNMLMCRNLKGLSTEGTITVNG 99

  Fly    96 MAMERHQMTRISSFLPQFEINVKTFTAYEHLYFMSHFKMHRRTTKAEKRQRVADLLLAVGLRDAA 160
            ..| .|:::.||.|..|.|:.|.|.|..|  |.|...|:....:|..:..||.|:|..:.|....
Worm   100 NEM-AHKISSISGFAQQEELFVGTLTVKE--YLMIQAKLRINGSKKLREDRVTDVLHQLKLWKCR 161

  Fly   161 HTRI------QQLSGGERKRLSLAEELITDPIFLFCDEPTTGLDSFSAYSVIKTLRHLCTRRRIA 219
            .::|      :.:||||.:||:.|.|::::|..||.||||||||||.|.|||:.|      :.||
Worm   162 DSKIGVIGEKKGISGGEARRLTFACEMLSNPSLLFADEPTTGLDSFMAESVIQIL------KGIA 220

  Fly   220 KHSLNQVYGEDSFETPSGESSASGSGSKSIEMEVVAESHESLLQTMRELPALGVLSNSPNGTHKK 284
            |..                                                             :
Worm   221 KTG-------------------------------------------------------------R 224

  Fly   285 AAICSIHQPTSDIFELFTHIILMDGGRIVYQGRTEQAAKFFTDLGYELPLNCNPADFYLKTLADK 349
            ..||:||||:|.::::|..:|.:..|...:||..:::..||...|:.:|...||:::.:..||.:
Worm   225 TIICTIHQPSSQLYQMFHRVIYLANGSTAFQGTPQESISFFEKCGHRVPDEYNPSEWIIYKLAVQ 289

  Fly   350 EGKENAGAVLRAKYEHETDGLYSGSWLLARSYSGDYLKHVQ-------------NFKKIRWIYQV 401
            .|:|          :...|.:..   ::.:....|:.|.|.             ...:.....|:
Worm   290 PGQE----------KQSNDRIQK---IVEQYEDSDHQKRVMEQLSDVSEKIPPPEMHRANVFTQI 341

  Fly   402 YLLMVRFMTEDLRNIRSGL------IAFGFFMITAVTLSLMYSGIGGLTQRTVQDVGGSIFMLSN 460
            :.|..|...:..|..:..|      |.||.| |..:.|...|..      |.:.::.|::|.|:.
Worm   342 FALSTRCGIDVWRAPQLTLAKVIQKILFGLF-IGLLYLRTPYDA------RGIHNINGALFFLAG 399

  Fly   461 EMIFTFSYGVTYIFPAALPIIRREVGEGTYSLSAYYVALVLSFVPVAFFKGYVFLSVIYASIYYT 525
            |.|::.:|.:.:......|::.||..:|.|:|..||.|..:|.:|:....|.:.|.::|..|...
Worm   400 EYIYSTAYAIMFFLNNEFPLVAREYHDGLYNLWTYYFARCISLIPLFSTDGLILLFIVYWLIGLN 464

  Fly   526 RGFLLYLSMGFLMSLSAVAAVGYGVFLSSLFESDKMASECAAPFDLIFLIFGGTYMNVDTVPG-- 588
            ...:..:....:..|::.||..:|:.:|.:|.:.:|.:..|:|..::|.:|||.|.|.:|.|.
Worm   465 TSVMQVIVASIITVLASQAASAFGIAMSCIFPTAQMTAVMASPPLVLFRLFGGLYGNTNTFPAAI 529

  Fly   589 --LKYLSLFFYSNEALMYKFWIDIDNIDCPVNEDHPCIKTGVEVLQQGSYRNADYTYWLDCFSLV 651
              |:::|::.::.|.|:...|.:||:.......:.....|. :||...::  ::....||...|:
Worm   530 RWLQWISMYRFAFEGLVVNQWSEIDDFHSNAKNNWTNSTTN-DVLDYFAF--SESAIPLDIIGLI 591

  Fly   652 VVAVIFHIVSF-GLVRR 667
            ::::.|:::.| .||.|
Worm   592 LISLAFYLIGFIALVHR 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bw	NP_001286769.1	P-loop_NTPase	31..316	CDD:304359	88/290 (30%)
		3a01204	40..673	CDD:273361	171/664 (26%)
		ABC2_membrane	404..604	CDD:279410	54/209 (26%)
wht-6	NP_498425.2	P-loop_NTPase	<3..>81	CDD:393306	21/45 (47%)
wht-6	NP_498425.2	3a01204	50..613	CDD:273361	169/652 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.780