DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bw and wht-1

DIOPT Version :9

Sequence 1:	NP_001286769.1	Gene:	bw / 37724	FlyBaseID:	FBgn0000241	Length:	675	Species:	Drosophila melanogaster
Sequence 2:	NP_001348731.1	Gene:	wht-1 / 175859	WormBaseID:	WBGene00015479	Length:	671	Species:	Caenorhabditis elegans

Alignment Length:	719	Identity:	192/719 - (26%)
Similarity:	309/719 - (42%)	Gaps:	157/719 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PSLC-LEWKQLNYYVPDQEQSNY--SFWNECRKKRELRILQDASGHMKTGDLIAILGGSGAGKTT 74
            |..| |.|..||...|:.:.:|:  .|.|...|:|...||.:.||..::|.|:||||.|||||||
Worm    44 PEGCNLYWSSLNVTGPETKPTNFVDRFRNNMPKRRVKEILHNVSGMAESGKLLAILGSSGAGKTT 108

  Fly    75 LLAAISQRLRGNLT-----GDVVLNGMAMERHQMTRISSFLPQFEINVKTFTAYEHLYFMSHFKM 134
            |:..::.|   |||     |.::::|....:.::..:|:|:.|.::.|.|.||.|||.||:..:|
Worm   109 LMNVLTSR---NLTNLDVQGSILIDGRRANKWKIREMSAFVQQHDMFVGTMTAREHLQFMARLRM 170

  Fly   135 HRRTTKAEKRQ-RVADLLLAVGLRDAAHT------RIQQLSGGERKRLSLAEELITDPIFLFCDE 192
            ..:.....:|| ||..:|..:||:..|.|      :::.||.||:||||.|.|::|.|..|||||
Worm   171 GDQYYSDHERQLRVEQVLTQMGLKKCADTVIGIPNQLKGLSCGEKKRLSFASEILTCPKILFCDE 235

  Fly   193 PTTGLDSFSAYSVIKTLRHLCTRRRIAKHSLNQVYGEDSFETPSGESSASGSGSKSIEMEVVAES 257
            ||:|||:|.|..|::.||.|
Worm   236 PTSGLDAFMAGHVVQALRSL--------------------------------------------- 255

  Fly   258 HESLLQTMRELPALGVLSNSPNGTHKKAAICSIHQPTSDIFELFTHIILMDGGRIVYQGRTEQAA 322
                               :.||   ...|.:||||:|.::.||.::.||..||::|.|..:||.
Worm   256 -------------------ADNG---MTVIITIHQPSSHVYSLFNNVCLMACGRVIYLGPGDQAV 298

  Fly   323 KFFTDLGYELPLNCNPADFYLKTLA--DKE--------------------GKE-----NAGAVLR 360
            ..|...||..|...||||..::|||  |.:                    |:.     ||..:..
Worm   299 PLFEKCGYPCPAYYNPADHLIRTLAVIDSDRATSMKTISKIRQGFLSTDLGQSVLAIGNANKLRA 363

  Fly   361 AKYEHETDGLYSGSWLLARSYSGDYLKHVQNFKKIRWIYQVYLLMVRFMTEDLRNIRSGLIAFGF 425
            |.:...:|..........:.|:..:.   ..|..:.|  :.:|.::|  ..:|.::|...|
Worm   364 ASFVTGSDTSEKTKTFFNQDYNASFW---TQFLALFW--RSWLTVIR--DPNLLSVRLLQI---- 417

  Fly   426 FMITAVTLSLMYSGIGGLTQRTVQDVGGSIFMLSNEMIFTFSYGVTYIFPAALPIIRREVGEGTY 490
             :|||....:::... .:|..|:..:.|.:|.....|.|...:....:..|.|||:.||...|.|
Worm   418 -LITAFITGIVFFQT-PVTPATIISINGIMFNHIRNMNFMLQFPNVPVITAELPIVLRENANGVY 480

  Fly   491 SLSAYYVALVLSFVPVAFFKGYVFLSVIYASIYYTRGFL-------LYLSMGFLMSLSAVAAVGY 548
            ..|||::|..::.:|     .|:.|.::|.:|.|....|       .:.|:..::..:...::.|
Worm   481 RTSAYFLAKNIAELP-----QYIILPILYNTIVYWMSGLYPNFWNYCFASLVTILITNVAISISY 540

  Fly   549 GVFLSSLFESDKMASECAAPFDLIFLIFGGTYMNVDTVPG----LKYLSLFFYSNEALMYKFWID 609
            .|  :::|.:..:|......|.:..:.|||.::..|.:|.    |..||.|.|..|||....|..
Worm   541 AV--ATIFANTDVAMTILPIFVVPIMAFGGFFITFDAIPSYFKWLSSLSYFKYGYEALAINEWDS 603

  Fly   610 IDNIDCPVNED------HPCIKTGVEVLQ----QGSYRNADYTYWLDCFSLVVVAVIFHIVSFGL 664
            |..|....|..      ..|.|.|.:||:    ..|::..|.:.....|  :.:.:|.::..  |
Worm   604 IKVIPECFNSSMTAFALDSCPKNGHQVLESIDFSASHKIFDISILFGMF--IGIRIIAYVAL--L 664

  Fly   665 VRRY 668
            :|.|
Worm   665 IRSY 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bw	NP_001286769.1	P-loop_NTPase	31..316	CDD:304359	94/298 (32%)
		3a01204	40..673	CDD:273361	182/689 (26%)
		ABC2_membrane	404..604	CDD:279410	51/210 (24%)
wht-1	NP_001348731.1	3a01204	76..667	CDD:273361	180/684 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48041
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920