DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bw and wht-4

DIOPT Version :9

Sequence 1:	NP_001286769.1	Gene:	bw / 37724	FlyBaseID:	FBgn0000241	Length:	675	Species:	Drosophila melanogaster
Sequence 2:	NP_494495.3	Gene:	wht-4 / 173671	WormBaseID:	WBGene00017179	Length:	636	Species:	Caenorhabditis elegans

Alignment Length:	710	Identity:	174/710 - (24%)
Similarity:	306/710 - (43%)	Gaps:	152/710 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ESGGSSGQGGPSLCLEWKQLNYYVPDQEQSNYSFWNECRKKRELRILQDASGHMKTGDLIAILGG 67
            ::|..|.:|..::.  |..|...||.....        ||:    ::::.||..:.|:::|::||
Worm    22 DTGDGSEKGRKTIA--WSGLVATVPQAGGG--------RKE----VIRNVSGVAEPGEVLALMGG 72

  Fly    68 SGAGKTTLLAAISQRLRGN---LTGDVVLNGMAMERHQMTRISSFLPQFEINVKTFTAYEHLYFM 129
            ||||||||:..:: .|..|   ..|||.:||..:.:.:|.::.:::.|.::...|.|..|.|.:.
Worm    73 SGAGKTTLMNILA-HLDTNGVEYLGDVTVNGKKITKQKMRQMCAYVQQVDLFCGTLTVREQLTYT 136

  Fly   130 SHFKMHRRTTKAEKRQRVADLLLAVGLRDAAHT------RIQQLSGGERKRLSLAEELITDPIFL 188
            :|.:| :..|..:|.:||.::|..:.|.|..:|      |::.:|.||:|||:.|.|::|||..|
Worm   137 AHMRM-KNATVQQKMERVENVLRDMNLTDCQNTLIGIPNRMKGISIGEKKRLAFACEILTDPKIL 200

  Fly   189 FCDEPTTGLDSFSAYSVIKTLRHLCTRRRIAKHSLNQVYGEDSFETPSGESSASGSGSKSIEMEV 253
            ||||||:|||:|.|..|::.|..|..:
Worm   201 FCDEPTSGLDAFMASEVVRALLDLANK-------------------------------------- 227

  Fly   254 VAESHESLLQTMRELPALGVLSNSPNGTHKKAAICSIHQPTSDIFELFTHIILMDGGRIVYQGRT 318
                                         .|..|..:|||:|.:|.:|..:..|..|:.||.|..
Worm   228 -----------------------------GKTIIVVLHQPSSTVFRMFHKVCFMATGKTVYHGAV 263

  Fly   319 EQAAKFFTDLG--YELPLNCNPADFYLKTLADKEGKENAGAVLRAKY-EHETDGLYSGSWLLARS 380
            ::...||..||  :.:|.:.|||||.:..::.....|... |.|.:| .||......|:.:|.::
Worm   264 DRLCPFFDKLGPDFRVPESYNPADFVMSEISISPETEQED-VTRIEYLIHEYQNSDIGTQMLKKT 327

  Fly   381 YS--------GDYLKHVQNFKKIRWIYQVYLLMVRFMTEDLRNIRSGLIAFGFFMITAVTLSLMY 437
            .:        ||.....::.....:..|..:|:.|.:....|:.....:.|...:.||:.:.::.
Worm   328 RTAVDEFGGYGDDEDDGESRYNSTFGTQFEILLKRSLRTTFRDPLLLRVRFAQILATAILVGIVN 392

  Fly   438 SGIGGLTQRTVQDVGGSIFMLSNEMIFTFSYGVTYIFPAALPIIRREVGEGTYSLSAYYVALVLS 502
            ..: .|...|:|::.|.::..:.:|.|.|.:....:..:.||:..||.....||:.||::|..|:
Worm   393 WRV-ELKGPTIQNLEGVMYNCARDMTFLFYFPSVNVITSELPVFLREHKSNIYSVEAYFLAKSLA 456

  Fly   503 FVPVAFFKGYVFLSVIYASIYY--------TRGFLLYLSMGFLMSLSAVAAVGYGVFLSSLFESD 559
            .:|     .|..|.:||.:|.|        ...||:::.:...::..||:....|   :.:|..:
Worm   457 ELP-----QYTILPMIYGTIIYWMAGLVASVTSFLVFVFVCITLTWVAVSIAYVG---ACIFGDE 513

  Fly   560 KMASECAAPFDLIFLIFGGTYMNVDTVP----GLKYLSLFFYSNEALMYKFWIDIDNID------ 614
            .:.......|.|..|:|||.|:|.:::|    .:.::|.|.:..|||....|.:||.|.
Worm   514 GLVVTFMPMFVLPMLVFGGFYVNANSIPVYYQYVSFVSWFKHGFEALEANQWKEIDKISGCDLIN 578

  Fly   615 ---------CPVNEDHPCIKTGVEVLQQGSYRNADYTYWLDCFSLVVVAVIFHIVSFGLV 665
                     ||.: |.|.|.|         .|..|...:.:...|.:...::.|:  |||
Worm   579 PLNATTTGYCPAS-DGPGILT---------RRGIDTPLYANVLILFMSFFVYRII--GLV 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bw	NP_001286769.1	P-loop_NTPase	31..316	CDD:304359	78/293 (27%)
		3a01204	40..673	CDD:273361	167/673 (25%)
		ABC2_membrane	404..604	CDD:279410	50/211 (24%)
wht-4	NP_494495.3	3a01204	49..636	CDD:273361	167/681 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48041
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920