DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bw and AgaP_AGAP001858

DIOPT Version :9

Sequence 1:	NP_001286769.1	Gene:	bw / 37724	FlyBaseID:	FBgn0000241	Length:	675	Species:	Drosophila melanogaster
Sequence 2:	XP_321211.4	Gene:	AgaP_AGAP001858 / 1281268	VectorBaseID:	AGAP001858	Length:	789	Species:	Anopheles gambiae

Alignment Length:	823	Identity:	169/823 - (20%)
Similarity:	298/823 - (36%)	Gaps:	269/823 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PSLCLEWKQLNYYVPDQEQSNYSFWNECRKKRELRILQDASGHMKTGDLIAILGGSGAGKTTLLA 77
            |.:.:::..::|.|.:..:..|.           .||:..:|..::|:|.||:|.|||||:||:.
Mosquito    68 PPIDIQFMDMSYSVSEGHKRGYK-----------TILKGINGKFRSGELTAIMGPSGAGKSTLMN 121

  Fly    78 AISQRLRGNLTGDVVLNGMAMERHQMTRISSFLPQFEINVKTFTAYEHLYFMSHFKMHRRTTKAE 142
            .::.....:|:|.|::||......:..::|.::.|.:..:...|..|.:...::.|:.:..:.:.
Mosquito   122 ILAGYKTSHLSGSVLINGKERNLRKFRKLSCYIMQDDRLLPYLTVREAMMVSANLKLGKDISVSA 186

  Fly   143 KRQRVADLLLAVGLRDAAHTRIQQLSGGERKRLSLAEELITDPIFLFCDEPTTGLDSFSAYSVIK 207
            ||..|.:::..:||.|||.|....||||:|||||:|.||:.:|..:|.||||:||||.:...:|.
Mosquito   187 KRAVVEEIIETLGLLDAASTLTLNLSGGQRKRLSIALELVNNPPVMFFDEPTSGLDSSTCSQLIA 251

  Fly   208 TLRHLCTRRRIAKHSLNQVYGEDSFETPSGESSASGSGSKSIEMEVVAESHESLLQTMRELPALG 272
            .|:.|                              ..|.::|
Mosquito   252 LLKSL------------------------------ARGGRTI----------------------- 263

  Fly   273 VLSNSPNGTHKKAAICSIHQPTSDIFELFTHIILMDGGRIVYQGRTEQAAKFFTDLGYELPLNCN 337
                          :|:||||::.|||||.::.::..|:.:||||......|...||.|.|...|
Mosquito   264 --------------VCTIHQPSARIFELFDNLYVLAEGQCIYQGRVNGLVPFLASLGLECPSYHN 314

  Fly   338 PADFYLKTLADKEGKENA---GAVLRAKYEH----------------ETDGLYSGSW-------L 376
            ||::.::....:.|..|:   .||...|..:                ..||...|:.       |
Mosquito   315 PANYVMEVACGEHGDWNSKLVTAVNNGKCNNYNQPLAQSKSTSNKNVSLDGTAPGATEREDELAL 379

  Fly   377 LARSYS-GDYL------------------------------------------------------ 386
            |....| |||.
Mosquito   380 LKTVVSTGDYTAISMPPAGNAAAPEAQLNNESKQPAGGTDRKPMLGNGAEAASAASQSTTTTTTT 444

  Fly   387 ------------------------------------------------------------KHVQN 391
                                                                        |....
Mosquito   445 ATTAVGTTGASVNPSSDATGPLLPAVVVPPAGPAQTQPGCKATCTTSLLDSTESVSITVPKKQAG 509

  Fly   392 FKKIRWIYQVYLLMVRFMTEDLRNIRSGLIAFGFFMITAVTLSLMYSGIGGLTQRTVQDVGGSIF 456
            |....|: |.::|:.|.|...:|:.....:.....:|....:.::|..||....:.:.: .|.||
Mosquito   510 FPTSGWM-QFWILLKRTMITIMRDQTLTQMRLLSHVIVGAIIGMIYYDIGNDASKIMSN-AGCIF 572

  Fly   457 MLSNEMIFTFSYGVTYIFPAALPIIRREVGEGTYSLSAYYVALVLSFVPVAFFKGYVFLSVIYAS 521
            ..:...:||........||..:.:..||.....|||.::|.|..::.:|..    .:|.||....
Mosquito   573 FTTMFTMFTAMMPTILTFPTEMAVFVREHLNYWYSLKSFYFAKTIADLPFQ----VLFTSVYVIV 633

  Fly   522 IYYTRG----------FLLYL--------SMGFLMSLSAVAAVGYGVFLSSLFESDKMASECAAP 568
            :||...          |:|..        |:|.|  :.|..:|..||||              .|
Mosquito   634 VYYLTSQPMDPKRVGMFVLICILTSLVAQSLGLL--IGAGMSVETGVFL--------------GP 682

  Fly   569 FDLI-FLIFGGTYMNVDTVPG----LKYLSLFFYSNE-ALMYKFWIDIDNIDCPVNEDHPCIKTG 627
            ...| .::|.|.::|.|.:|.    :.|:|...|..| |::..:.::.:.:.|  .|.:...::.
Mosquito   683 VSTIPIILFSGFFVNFDVIPSYLQWVTYVSYVRYGFEGAMVSVYGMEREKLAC--TEIYCHFRSP 745

  Fly   628 VEVLQQGSYRNADYTYWLDCFSLVVVAVIFHIVSFGLVRRYIH 670
            .:.|::.|..||:  ||:|..:|....:...::::.::|..:|
Mosquito   746 KKFLEEMSMDNAE--YWIDATALFGFFIALRVIAYFVLRWKLH 786

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bw	NP_001286769.1	P-loop_NTPase	31..316	CDD:304359	74/284 (26%)
		3a01204	40..673	CDD:273361	165/796 (21%)
		ABC2_membrane	404..604	CDD:279410	51/223 (23%)
AgaP_AGAP001858	XP_321211.4	ABCG_EPDR	69..293	CDD:213180	76/301 (25%)
		3a01204	86..782	CDD:273361	164/799 (21%)
		ABC2_membrane	521..724	CDD:279410	51/223 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810