DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bw and AgaP_AGAP002050

DIOPT Version :9

Sequence 1:	NP_001286769.1	Gene:	bw / 37724	FlyBaseID:	FBgn0000241	Length:	675	Species:	Drosophila melanogaster
Sequence 2:	XP_320998.5	Gene:	AgaP_AGAP002050 / 1281063	VectorBaseID:	AGAP002050	Length:	895	Species:	Anopheles gambiae

Alignment Length:	702	Identity:	139/702 - (19%)
Similarity:	250/702 - (35%)	Gaps:	225/702 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 LQDASGHMKTGDLIAILGGSGAGKTTLLAAISQRLRGNLTGDVVLNGMAMERHQMTRISSFLPQF 113
            |:..|...|.|||.||:..:....|.|:.|:: .:|..:.|::::||..:.|..:.::..::|..
Mosquito   298 LRGVSLQAKAGDLFAIMATAQREGTALVEALA-GVRQRIAGEILVNGQQVNRRILRQLCGYVPAL 361

  Fly   114 EI----------NVKTFTA-----YEHLYFMSHFKMHRRTTKAEKRQRVADLLLAVGLRDAAHTR 163
            :.          :..:|.|     |:               :|:.::|:..|:..:||.......
Mosquito   362 DAAPLDPRMSVQSTLSFAAALRGPYD---------------RADLKERIDILVEDLGLTAVRSAN 411

  Fly   164 IQQLSGGERKRLSLAEELITDPIFLFCDEPTTGLDSFSAYSVIKTLRHLCTRRRIAKHSLNQVYG 228
            :.:|:..|::||::|.:|:|....|..|:.|..:|.|..:.:::.||..|:..||
Mosquito   412 VSRLTHSEKQRLNVACQLLTQASILLLDQTTINMDIFDTFFLVEYLRQWCSAGRI---------- 466

  Fly   229 EDSFETPSGESSASGSGSKSIEMEVVAESHESLLQTMRELPALGVLSNSPNGTHKKAAICSIHQP 293
                                                                     .|.::..|
Mosquito   467 ---------------------------------------------------------VIMTLQPP 474

  Fly   294 TSDIFELFTHIILMDGGRIVYQGRTEQAAKFFTDLGYELPLNCNPADFYLK--TLADKEGKENAG 356
            |.:|..:.:.::|:.|||.||.|......:....|||..|...||||:||.  ||.|.    :|.
Mosquito   475 TFEILSMCSGVLLLSGGRTVYSGSRADLPRHMGQLGYPCPPFKNPADYYLDLVTLDDL----SAA 535

  Fly   357 AVLRAKYEHETDGLYSGSWLLARSYSGDYLKH-------VQNF----KKIRWIYQVYLLMVRFMT 410
            |:|.:....|:   .:.||        |::..       |.|.    :...:..|:..|..|:||
Mosquito   536 ALLESSARIES---LANSW--------DHVNSEPPLAAPVANLPEPTRSAGFFSQINALAKRYMT 589

  Fly   411 EDLRNIRSGLIAFGFFMITAVTLSLMYSGIGGLTQRTVQDVGGSIFM----------LSNEMIFT 465
               ......|:.:...:|.|..|||:.               |.||.          |::.:.:.
Mosquito   590 ---YKQPGSLLTWISRLILAAVLSLLI---------------GCIFWDVPASDPQLNLNDRLGYH 636

  Fly   466 FSYGVTYIFPAALPIIR----------REVGEGTYSLSAY-YVALVLSFVP-VAFFKGYVFLSVI 518
            ....:..::|..|..||          :::..|.|....| .:...||.:| :..:..|:..:..
Mosquito   637 HCMMMVALWPLLLLQIRDVQEDRRHAEKDLKLGLYGRFLYMIIQSTLSVMPSLCIWLAYLLPAHS 701

  Fly   519 YASIY-YT----RGFLLYLSMGF-LMSLSAVAAVGYGVFLSSLFESDKMASECAAPFDLIFLIFG 577
            .|.:| ||    .|  :||.||: |:.|.|:..:  .:|::.|......||.......|.....|
Mosquito   702 MAGLYSYTTNNDTG--IYLYMGYMLLYLMAIQTI--VLFIAHLVPCGVTASIVTTLVLLTMAAVG 762

  Fly   578 GTYMNVDTVPG-LKYLSLFF-------------YSNEALMYKFWIDIDNIDCPVNEDHPCIKTGV 628
            |..::|..||. |:::.|..             ||.|.|            ..:.....|....|
Mosquito   763 GFAVHVANVPDYLRWMELVAPQKWLTPLLTENEYSAETL------------ASITSQQQCRNKQV 815

  Fly   629 E----VLQQ------GSYRNADY-------------TYWLDCFSLVVVAVIF 657
            :    ::||      |::..||:             .|......|::..::|
Mosquito   816 QYTEIIVQQPCPPPNGTFVLADHQLLPRDHVLDAADMYTSTVLGLLLTCIVF 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bw	NP_001286769.1	P-loop_NTPase	31..316	CDD:304359	52/281 (19%)
		3a01204	40..673	CDD:273361	139/702 (20%)
		ABC2_membrane	404..604	CDD:279410	53/241 (22%)
AgaP_AGAP002050	XP_320998.5	PhnC	285..502	CDD:226164	53/286 (19%)
		P-loop_NTPase	298..497	CDD:304359	52/281 (19%)
		ABC2_membrane	600..794	CDD:279410	44/212 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900