DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bw and AgaP_AGAP009464

DIOPT Version :9

Sequence 1:	NP_001286769.1	Gene:	bw / 37724	FlyBaseID:	FBgn0000241	Length:	675	Species:	Drosophila melanogaster
Sequence 2:	XP_310232.4	Gene:	AgaP_AGAP009464 / 1271437	VectorBaseID:	AGAP009464	Length:	758	Species:	Anopheles gambiae

Alignment Length:	778	Identity:	173/778 - (22%)
Similarity:	296/778 - (38%)	Gaps:	207/778 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SGQGGPSLCLEWKQL----NYYVPDQEQSNYSF---------WNECRKKRELR-ILQDASGHMKT 58
            |.:||.:..|....|    :|:.|.:...:..|         :|..:.|.|.: ||...:|..|:
Mosquito    66 SQEGGNNNTLYHNGLLEKQDYHFPKRPPVDIVFRDIRYDVRRFNIAKAKFESKEILHGLNGSFKS 130

  Fly    59 GDLIAILGGSGAGKTTLLAAISQRLRGNLTGDVVLNGMAMERH--QMTRISSFLPQFEINVKTFT 121
            |:|.||:|.|||||:|||..::..:...::|.|.:||.:...:  ...::|.::.|.:......|
Mosquito   131 GELTAIMGPSGAGKSTLLNIMAGYVSSGVSGMVQVNGKSRSHNSESFRKLSCYIQQHDALRPWLT 195

  Fly   122 AYEHLYFMSHFKMHRRTTKAEKRQRVADLLLAVGLRDAAHTRIQQLSGGERKRLSLAEELITDPI 186
            ..|.:...:|.|:......||||:.:..:|..:||....:|....||||::|||::|.|:|::|.
Mosquito   196 VTEAMTCATHLKLGFGIGMAEKRRLIEKILFMLGLEQKGNTPTMGLSGGQKKRLAIALEMISNPP 260

  Fly   187 FLFCDEPTTGLDSFSAYSVIKTLRHLCTRRRIAKHSLNQVYGEDSFETPSGESSASGSGSKSIEM 251
            .||.|||||||||.|....|..|:.|               .:|.
Mosquito   261 ILFLDEPTTGLDSSSCAQCISLLKRL---------------AQDG-------------------- 290

  Fly   252 EVVAESHESLLQTMRELPALGVLSNSPNGTHKKAAICSIHQPTSDIFELFTHIILMDGGRIVYQG 316
                                            :..:|:||.|::.:||:|..:..:..|...|||
Mosquito   291 --------------------------------RTIVCTIHTPSALLFEMFDQLYTVVQGHCFYQG 323

  Fly   317 RTEQAAKFFTDLGYELPLNCNPADFYLKTLADKEGKENAGAVLRA---KY--------------- 363
            .|::...|..||||..|...|||||.::....:.|.: .|.|::|   ||
Mosquito   324 PTKEMLPFLGDLGYHCPSYHNPADFMMEIAVGEYGAD-VGKVIKAALKKYYEISSRCIELDSTFD 387

  Fly   364 -----------------------------------------EHETDGLYSGSWLL---------- 377
                                                     |..:.|..|.|.:|
Mosquito   388 DNGKLLRRHPPFEICPLSVLPLLCFAVPSLDRSAVTSASLVESSSTGPNSSSEVLILLLCRIFQK 452

  Fly   378 ------ARSYSGDYLKHVQN--FKKIR---WIYQVYLLMVRFMTEDLRNIRSGLIAFGFFMI--- 428
                  ||..:.|...:.:.  |.|.:   .:.|..||..|.:....||         :|::
Mosquito   453 NAGKPRARQEALDNSSYEEEDIFSKTKPASLVMQFLLLFYRNLLMTRRN---------YFLLFCR 508

  Fly   429 ------TAVTLSLMYSGIGGLTQRTVQD---VGGSIFMLSNEMIFTFSYGVTYIFPAALPIIRRE 484
                  .|.....:|.|:|....:.:.:   :.||:.|    |::|....|...|...:..:.||
Mosquito   509 IIAHAAVATIFGYLYLGVGPNANQVLANYVYLYGSMLM----MVYTGKMAVVLSFQIEMESLTRE 569

  Fly   485 VGEGTYSLSAYYVALVLSFVPVAFFKGYVFLSVIYASI-YYTRGFLLYLSMGFLMSLSAVA---- 544
            .....|.|..|::::::..:|:     .:..|:||..| |:..|..:.:....:.:|..||
Mosquito   570 HFNRWYKLGPYFLSVLVLEIPI-----QICCSLIYVVISYHLTGNYVNMERFCIFALFCVAGSIC 629

  Fly   545 AVGYGVFLSSLFESDKMASECAAPFDLIFLIFGGTYMNVDTVPGLK---YLSLFFYSNEALMYK- 605
            |..:|.|:.:.. |.|:|........::|.:||.....||..|..|   ::|.:..|...:|..
Mosquito   630 AQSWGFFVGATL-SVKLAVFIGPILAVLFSVFGFCTRYVDITPVFKWMWHISYYRASFHGIMNSV 693

  Fly   606 FWIDIDNIDCPVNEDHPCIKTGVEVLQQGSYRNADYTYWLDCFSLVVVAVIFHIVSFGLVRRY 668
            :.::..::.||..:.:...|..|...:.....:.|..   ..|.|:::.:|...:|..||..|
Mosquito   694 YGMNRGDLHCPETQIYCHFKNPVLFQKDMDIEHVDMQ---SNFVLIMLIIITMYISTVLVLWY 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bw	NP_001286769.1	P-loop_NTPase	31..316	CDD:304359	75/296 (25%)
		3a01204	40..673	CDD:273361	164/733 (22%)
		ABC2_membrane	404..604	CDD:279410	46/219 (21%)
AgaP_AGAP009464	XP_310232.4	ABCG_EPDR	93..323	CDD:213180	75/296 (25%)
		3a01204	118..757	CDD:273361	162/726 (22%)
		ABC2_membrane	490..690	CDD:279410	46/218 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910