DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bw and Abcg5

DIOPT Version :9

Sequence 1:	NP_001286769.1	Gene:	bw / 37724	FlyBaseID:	FBgn0000241	Length:	675	Species:	Drosophila melanogaster
Sequence 2:	NP_446206.2	Gene:	Abcg5 / 114628	RGDID:	620298	Length:	652	Species:	Rattus norvegicus

Alignment Length:	703	Identity:	178/703 - (25%)
Similarity:	289/703 - (41%)	Gaps:	177/703 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 FWN--ECRKKRELRILQDASGHMKTGDLIAILGGSGAGKTTLLAAISQRLR--GNLTGDVVLNGM 96
            :||  .|::|.:.:||:|.|.::::|..:.|||.||:||||||.|||.|||  |.|.|:|.:||.
  Rat    55 WWNIKSCQQKWDRKILKDVSLYIESGQTMCILGSSGSGKTTLLDAISGRLRRTGTLEGEVFVNGC 119

  Fly    97 AMERHQMTRISSFLPQFEINVKTFTAYEHLYFMSHFKMHRRTTKAE-KRQRVADLLLAVGLRDAA 160
            .:.|.|.....|:|.|.::.:.:.|..|.|.:.:...:  |::.|: ..::|..:|..:.|...|
  Rat   120 ELRRDQFQDCVSYLLQSDVFLSSLTVRETLRYTAMLAL--RSSSADFYDKKVEAVLTELSLSHVA 182

  Fly   161 HTRIQQ-----LSGGERKRLSLAEELITDPIFLFCDEPTTGLDSFSAYSVIKTLRHLCTRRRIAK 220
            ...|..     :|.|||:|:|:|.:|:.||..:..||||||||..:|..::..|..|..|.||
  Rat   183 DQMIGNYNFGGISSGERRRVSIAAQLLQDPKVMMLDEPTTGLDCMTANHIVLLLVELARRNRI-- 245

  Fly   221 HSLNQVYGEDSFETPSGESSASGSGSKSIEMEVVAESHESLLQTMRELPALGVLSNSPNGTHKKA 285

  Rat   246 ----------------------------------------------------------------- 245

  Fly   286 AICSIHQPTSDIFELFTHIILMDGGRIVYQGRTEQAAKFFTDLGYELPLNCNPADFYLK-TLADK 349
            .|.:||||.|::|..|..|.::..|.:|:.|..|:...||.:.||..|.:.||.|||:. |..|.
  Rat   246 VIVTIHQPRSELFHHFDKIAILTYGELVFCGTPEEMLGFFNNCGYPCPEHSNPFDFYMDLTSVDT 310

  Fly   350 EGKENAGAVLRAKYEHETDGLYSGSWLLARSYSGDYLKH--VQNFKKIRWIYQVYLLMVRFMTED 412
            :.:|.         |.||   |....:|..::....:.|  ::|.::.|.:..  |.||.|.|::
  Rat   311 QSRER---------EIET---YKRVQMLESAFRQSDICHKILENIERTRHLKT--LPMVPFKTKN 361

  Fly   413 -----------LRNIRSGL--------------IAFGFFMITAVTLSLMYSGIGGLTQRTVQDVG 452
                       ||.:...|              :..|.|:|..: |.:..:.:.|    .|||..
  Rat   362 PPGMFCKLGVLLRRVTRNLMRNKQVVIMRLVQNLIMGLFLIFYL-LRVQNNMLKG----AVQDRV 421

  Fly   453 GSIFMLSNEMIFTFSYGVTYIFPAALPIIRREVGEGTYSLSAYYVALVLSFVPVAFFKGYVFLSV 517
            |.::.|.....:|.......:||....:..:|..:|.|......:|.||..:|.:     :..:|
  Rat   422 GLLYQLVGATPYTGMLNAVNLFPMLRAVSDQESQDGLYQKWQMLLAYVLHALPFS-----IVATV 481

  Fly   518 IYASI-YYTRGFLLYLSMGFLMSLSAVAAVGY-----------GVFLS----SLFESDKMASECA 566
            |::|: |:|.|  ||         ..||..||           |.||:    .:.::..:.:...
  Rat   482 IFSSVCYWTLG--LY---------PEVARFGYFSAALLAPHLIGEFLTLVLLGMVQNPNIVNSIV 535

  Fly   567 APFDLIFLIFG-GTYMNVDTVP-GLKYLSLFFYS---------NEALMYKFWIDIDNIDCPVNED 620
            |...:..|:.| |...|::.:| .||.|..|.:.         ||.....|.....|...|.|.
  Rat   536 ALLSISGLLIGSGFIRNIEEMPIPLKILGYFTFQKYCCEILVVNEFYGLNFTCGGSNTSVPNNP- 599

  Fly   621 HPCIKT-GVEVLQQ---GSYRNADYTYWLDCFSLVVVAVIFHIVSFGLVRRYI 669
             .|..| |::.:::   |: .:...|.:|..:|.:...||..:|.| .||.|:
  Rat   600 -MCSMTQGIQFIEKTCPGA-TSRFTTNFLILYSFIPTLVILGMVVF-KVRDYL 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bw	NP_001286769.1	P-loop_NTPase	31..316	CDD:304359	82/289 (28%)
		3a01204	40..673	CDD:273361	176/697 (25%)
		ABC2_membrane	404..604	CDD:279410	54/251 (22%)
Abcg5	NP_446206.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30
		ABCG_White	50..276	CDD:213201	82/289 (28%)
		3a01204	61..646	CDD:273361	173/692 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48041
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920