DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bw and abca10

DIOPT Version :9

Sequence 1:	NP_001286769.1	Gene:	bw / 37724	FlyBaseID:	FBgn0000241	Length:	675	Species:	Drosophila melanogaster
Sequence 2:	XP_031750511.1	Gene:	abca10 / 100485734	XenbaseID:	XB-GENE-6464279	Length:	1610	Species:	Xenopus tropicalis

Alignment Length:	768	Identity:	147/768 - (19%)
Similarity:	247/768 - (32%)	Gaps:	285/768 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 KKRELRILQDASGHMKTGDLIAILGGSGAGKTTLLAAISQRLRGNLTGDVVLN-GMAMERH--QM 103
            |.:....|:|...::..|.:.|:||.|||||||||..:|.....:.....|.| .::..||  ::
Frog   489 KDKNTEALRDLDLNIYEGQITALLGHSGAGKTTLLNILSGMCPTSGGSATVCNYKLSNMRHLGEI 553

  Fly   104 TRISSFLPQFEINVKTFTAYEHLYFMSHFKMHRRTTKAEKRQRVADLLLAVGLRDAAHTRIQQLS 168
            .:...|.||.:|.....|..|:|   :.|.|.:.....|...:|..:|..:.:.|..:....:||
Frog   554 KKRVGFCPQGDIKFDPLTVKENL---TVFAMIKGIPSKEVAHKVQTVLSDLQMNDIENIEASKLS 615

  Fly   169 GGERKRLSLAEELITDPIFLFCDEPTTGLDSFSAYSVIKTLRH---------------------- 211
            ||::::|:....::.||..|..||||.|||..|.:::...|:.
Frog   616 GGQKRKLTFGIAILGDPQVLLLDEPTAGLDPCSRHNIWTILKESKADRVTLLSTQFMDEADILAD 680

  Fly   212 ----------------LCTRRR--IAKHSLNQV-------------------------------- 226
                            |..:|:  :..|...||
Frog   681 RKVVISKGKLKCVGTSLFLKRKWGVGYHLRMQVSPSCDVELMTSIIKQHIPSTKLTTQNEEELTY 745

  Fly   227 ---------------------------YG------EDSF-------ETPSGESSASGSGSKSIE- 250
                                       ||      :|.|       |..||:.......|::.|
Frog   746 TLPFENMDVFPDLFLHLDGQVGNSIVNYGVSMTTLDDVFLKLEGEGEIESGDYDVFNPESRTNED 810

  Fly   251 -MEVVAESHESLLQTMRELPALGVLSNSPNGT--------HKKAAICSI------HQP------- 293
             .:...|..|||||          :|:|.|.|        .:..|:..|      |..
Frog   811 REDFSTEMEESLLQ----------MSDSGNVTLSGWELWRQQVLAVARIRLLKLRHDTKSFRSIL 865

  Fly   294 ---------------------TSDIFELFTHIILMDGGRIVYQGRTEQAAKFFTDLGYELPLNCN 337
                                 |.|.:||..|        :.:|....:..|::|||     |.||
Frog   866 LLLVVITLPPIIIIITSNIVNTFDAWELTPH--------LYFQSPRNRLNKYYTDL-----LICN 917

  Fly   338 PADFYLKTLADKEGKENAGA-VLRAKYEHETDGLYSGSWLLARSYSGDYLKHVQNFKKIR----- 396
            .....::.......::|... |:..:|:.|| ..|.|:..:::...|.....|.|.|...
Frog   918 NTGSSIEDFVGAVKEQNIEVQVVNGEYDTET-VKYRGAIEVSQMEKGYNFTIVANPKAFNSLPVL 981

  Fly   397 --------------------W-----------IYQVYLLMVRFM--------------TEDLR-N 415
                                |           |:..|:.::.|:              |||.| |
Frog   982 LNIISNALLKILKVSGHFRVWNHPITTDGTDIIFLPYMSLIFFIIFASAFCPHIAMSSTEDNRIN 1046

  Fly   416 IR-----SGLIAFGFFMITAVTLSLMYSGIGGLTQRTVQDVGGSIFMLSNEMIFTFSYGVTYIFP 475
            .|     |||....::...|:...::|               ..:..|...:.|.|:..:...|.
Frog  1047 ARNQLRISGLFPSAYWFGQALVDVILY---------------WILLFLMVAIYFAFNSYILLDFV 1096

  Fly   476 AALPIIRREVGEGTYSLSAYYVALVLSFVPVAFFKG----------YVFLS---VIYASIYYTRG 527
            .|:.:|...:|.||..:...|   |:||:   |.:|          :|..|   |::..::..|.
Frog  1097 PAMVMIIGIIGYGTAMVLYVY---VISFI---FGRGKSHTDSWSLFFVITSTFPVMFMDVFMFRL 1155

  Fly   528 FLLYLSMGFLMSLSAVAAVGYGVFLSSLF----ESDKMASECAAPFDLIFLIF 576
            |.:|.   |:...||::.:....:...:|    |...:..:| .|:..|.:.|
Frog  1156 FTIYY---FVFPASALSGIMEYTYRLQVFPGGSEYTALIEQC-TPYLHIIIFF 1204

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bw	NP_001286769.1	P-loop_NTPase	31..316	CDD:304359	83/432 (19%)
		3a01204	40..673	CDD:273361	147/768 (19%)
		ABC2_membrane	404..604	CDD:279410	42/210 (20%)
abca10	XP_031750511.1	rim_protein	<107..1597	CDD:130324	147/768 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000