DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment seq and RPH1

DIOPT Version :9

Sequence 1:	NP_001027415.1	Gene:	seq / 3772396	FlyBaseID:	FBgn0028991	Length:	882	Species:	Drosophila melanogaster
Sequence 2:	NP_011096.1	Gene:	RPH1 / 856916	SGDID:	S000000971	Length:	796	Species:	Saccharomyces cerevisiae

Alignment Length:	424	Identity:	84/424 - (19%)
Similarity:	144/424 - (33%)	Gaps:	110/424 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 SSPQQQQ-----QQQQQQQNVATSVADNVVTTISSSSILHTNANTNGVDTLAATQQQQQQQQQQQ 161
            ||.|:|.     :::..|..:.|...||:| .:|.:|:.::.|::..:.........:....|..
Yeast   458 SSFQEQPLNKLLKRETSQTAMLTDHEDNIV-AMSLTSMANSAASSPRLPLSRLNSSNELSNAQPL 521

  Fly   162 QQQQQQHYHYITTTGEDGQTPTTIVFENYNGGMPAVSSAAP-TPVP-----VSQANAPATTTTTA 220
            .........:....|..|..|...:   .|..:..:|.:|| :||.     :.:..:|...|...
Yeast   522 LDMTNNTLAFPRPNGPSGLNPLLYI---SNKNISGISHSAPHSPVNPNISLIKRVKSPNIVTLNI 583

  Fly   221 LVNTDGTIIEFDGSTYE--EYHVLKSEPGSSDCLSNGSSAVAADIIKYDPQHGVVGDEEDDDENG 283
            ...:..:.|..:   ||  :.|..:....:...:||.|::|...:               .|.|
Yeast   584 SRESSRSPIALN---YEARQQHSQQHSFSTPSTVSNLSTSVLGPL---------------SDTN- 629

  Fly   284 MLHVKYEEQSLEHDPENEHDAEQEHEYEEYQVIKAEVEAEAAELAAGTTSYTISQEQTGSGNTVL 348
                         |.:..|.....|:... :::|.|                 |..:|...|.:|
Yeast   630 -------------DIKTPHPERPNHKTAN-RILKKE-----------------SPVETSKSNLIL 663

  Fly   349 SSMVPKSGSAAAAKQKRKRKTRVIADD---EQGEYLEKMSVRGLDIARYEHIIDGVAYCLVCAKN 410
            |.:       |:.:|:....:|  .||   |||.     |......|..|.::.|.....:|  .
Yeast   664 SKV-------ASTRQEDSFTSR--NDDLDKEQGS-----SPLNSKFAPEEIVLSGKNKIYIC--K 712

  Fly   411 DIFKTFKNKYSFQRHAYLFHEGQNRKIFACPICNKEFSRPDKMKMHKKDKHGDVPMPPSATTTPL 475
            :..:.|.:.:...||....|.|:  |..:||.|.|.|.|.|.:..|...|   :|...:.||
Yeast   713 ECQRKFSSGHHLTRHKKSVHSGE--KPHSCPKCGKRFKRRDHVLQHLNKK---IPCISNETT--- 769

  Fly   476 KADGPPAKRARTARTPRVRKTKDG-------STP 502
             .|.|       ...|.| :.:||       |||
Yeast   770 -VDAP-------IMNPTV-QPQDGKAAINQQSTP 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
seq	NP_001027415.1	C2H2 Zn finger	404..430	CDD:275370	4/25 (16%)
RPH1	NP_011096.1	JmjN	13..54	CDD:128818
		JmjC	222..338	CDD:396791
		COG5048	507..>759	CDD:227381	59/322 (18%)
		C2H2 Zn finger	711..732	CDD:275368	4/22 (18%)
		C2H2 Zn finger	740..757	CDD:275368	7/16 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900