DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment seq and GIS1

DIOPT Version :9

Sequence 1:	NP_001027415.1	Gene:	seq / 3772396	FlyBaseID:	FBgn0028991	Length:	882	Species:	Drosophila melanogaster
Sequence 2:	NP_010381.1	Gene:	GIS1 / 851670	SGDID:	S000002503	Length:	894	Species:	Saccharomyces cerevisiae

Alignment Length:	524	Identity:	89/524 - (16%)
Similarity:	164/524 - (31%)	Gaps:	165/524 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 PKLSQTSAATGGATAAAEASTSKSSQGQQQQIVY---VNMLPAANTLNGIPQQQQQQQYASTDGN 73
            |.|:.|::.....||.:...::.::..|....|.   :|...||:..|.|.........:|::.|
Yeast   473 PSLTNTNSLLSNITATSTNPSTTTNGSQNHNNVNANGINTSAAASINNNISSTNNSANNSSSNNN 537

  Fly    74 VYQLQNEIL--------------CDANGHAVTAATASYQTTA---------SSPQQQQQQQQQQQ 115
            |..:.:.::              .|.|..|::.||.:...||         |||        ...
Yeast   538 VSTVPSSMMHSSTLNGTSGLGGDNDDNMLALSLATLANSATASPRLTLPPLSSP--------MNP 594

  Fly   116 NVATSVADNVVTTISSSSILHTNANTNGVDTLAATQQQQQQQQQQQQQQQQQHYHYITTTGED-- 178
            |..||...|::...|.:....:|:.:|||.|.|||.....              |.::....:
Yeast   595 NGHTSYNGNMMNNNSGNGSNGSNSYSNGVTTAAATTTSAP--------------HNLSIVSPNPT 645

  Fly   179 -GQTPTTIVFEN----YNGGM----PAVSS-----------------AAPTPVP--VSQANAPAT 215
             ...|.::...|    .|.|:    |:.|:                 |:.:|:.  |:...:|..
Yeast   646 YSPNPLSLYLTNSKNPLNSGLAPLSPSTSNIPFLKRNNVVTLNISREASKSPISSFVNDYRSPLG 710

  Fly   216 TTTTALVNTDGTIIEFDGSTYEEYHVLKSEPGSSDCLSNGSSAVAADIIKYDPQHG----VVGDE 276
            .:...:.::  ||.::...|     .::....:.:.|..|.|        :.|.|.    :.|::
Yeast   711 VSNPLMYSS--TINDYSNGT-----GIRQNSNNINPLDAGPS--------FSPLHKKPKILNGND 760

  Fly   277 EDDDENGMLHVKYEEQSLEHDPENEHDAEQEHEYEEYQVIKAEVEAEAAELAAGTTSYTISQEQT 341
            ..:.::......:.....|.:|                                    :|....|
Yeast   761 NSNLDSNNFDYSFTGNKQESNP------------------------------------SILNNNT 789

  Fly   342 GSGNTVLSSMVPKSGSAAAAKQKRKRKTRVIADDEQGEYLEKMSVRGLDIARYEHIIDGVAYCLV 406
            .:.:...:|.:..:|:...|...:..:..||..|....|:                      |..
Yeast   790 NNNDNYRTSSMNNNGNNYQAHSSKFGENEVIMSDHGKIYI----------------------CRE 832

  Fly   407 CAKNDIFKTFKNKYSFQRHAYLFHEGQNRKIFACPICNKEFSRPDKMKMHKKDKHGDVPMPPSAT 471
            |.:.     |.:.:...||....|.|:  |..:||.|.|.|.|.|.:..|...|   :|......
Yeast   833 CNRQ-----FSSGHHLTRHKKSVHSGE--KPHSCPRCGKRFKRRDHVLQHLNKK---IPCTQEME 887

  Fly   472 TTPL 475
            .|.|
Yeast   888 NTKL 891

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
seq	NP_001027415.1	C2H2 Zn finger	404..430	CDD:275370	5/25 (20%)
GIS1	NP_010381.1	JmjN	11..52	CDD:128818
		JmjC	191..307	CDD:202224
		zf-C2H2_4	828..851	CDD:290605	6/49 (12%)
		C2H2 Zn finger	830..851	CDD:275368	5/25 (20%)
		zf-H2C2_2	842..868	CDD:290200	10/27 (37%)
		C2H2 Zn finger	859..876	CDD:275368	7/16 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900