DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment seq and MLLT10

DIOPT Version :9

Sequence 1:	NP_001027415.1	Gene:	seq / 3772396	FlyBaseID:	FBgn0028991	Length:	882	Species:	Drosophila melanogaster
Sequence 2:	XP_024303947.1	Gene:	MLLT10 / 8028	HGNCID:	16063	Length:	1102	Species:	Homo sapiens

Alignment Length:	979	Identity:	180/979 - (18%)
Similarity:	318/979 - (32%)	Gaps:	352/979 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQQSRKFEGKIPKLSQTSAATGGAT--AAAEASTSKSSQGQQQQIVYVNMLPAANTLNGIPQQQQ 63
            :.::|..|||..|.|..|:...|..  ......|:.|:.....|..:.....:..:.:|...|..
Human   307 VSETRGSEGKGKKSSAHSSGQRGRKPGGGRNPGTTVSAASPFPQGSFSGTPGSVKSSSGSSVQSP 371

  Fly    64 QQQYASTDGNVYQLQNEILCDANGHAVTAATASYQTTASSPQQQQQQQQQQQNV----------A 118
            |...:.||.:   |:|    |:..|       |.|::|:....:.:...|:..|          :
Human   372 QDFLSFTDSD---LRN----DSYSH-------SQQSSATKDVHKGESGSQEGGVNSFSTLIGLPS 422

  Fly   119 TSVA-------DNVVTTISSSSIL---HTNANTNGVDTLAATQQQQQQQQQQQQ-------QQQQ 166
            ||..       :|....:.:||:.   :..|.|:|::.....:::::..:|.:.       .:.|
Human   423 TSAVTSQPKSFENSPGDLGNSSLPTAGYKRAQTSGIEEETVKEKKRKGNKQSKHGPGRPKGNKNQ 487

  Fly   167 QHYHYITTTGEDGQTPTTIVFENYNGGMPAVSSAAPTPVPVSQANAPATTTTTALVNTDGTIIEF 231
            ::..::                       :||||:||.   |.|:|..:.|:::|..:. |::
Human   488 ENVSHL-----------------------SVSSASPTS---SVASAAGSITSSSLQKSP-TLL-- 523

  Fly   232 DGSTYEEYHVLKSEPGSSDCLSNGSSAVAADI-IKY---------------DPQHGVVGDEEDDD 280
                         ..||...||.|||.|.::| ::|               :..|...||.....
Human   524 -------------RNGSLQSLSVGSSPVGSEISMQYRHDGACPTTTFSELLNAIHNDRGDSSTLT 575

  Fly   281 ENGMLHVKYEE--------QSLEHD-----------------------PENEHDAEQEHEYEEYQ 314
            :..:..:.|.|        |:|.::                       |.:.....|:......|
Human   576 KQELKFIVYLEFIKWAYSSQNLRNEGIYNSNDVAVSFPNVVSGSGSSTPVSSSHLPQQSSGHLQQ 640

  Fly   315 V--IKAEVEAEAAELAAGTTSYTISQEQTGS------GNTVLSSMVPKSGSAAAAKQKRKRKTRV 371
            |  :.....:.||...|.|.:.|:|......      ||...|||     :|..|:.:..:..:.
Human   641 VGALSPSAVSSAAPAVATTQANTLSGSSLSQAPSHMYGNRSNSSM-----AALIAQSENNQTDQD 700

  Fly   372 IADDE----------QGEYLEKMSVRGLDIARYEHIIDGVAYCLVCAKNDIFKTFKNKYSFQRHA 426
            :.|:.          :|....:..|..|.| ||:...:.....|......|.:..:.::| :...
Human   701 LGDNSRNLVGRGSSPRGSLSPRSPVSSLQI-RYDQPGNSSLENLPPVAASIEQLLERQWS-EGQQ 763

  Fly   427 YLFHE-------GQNRKIFACPICNKEFSRPDKMKMHKKDK----HGDVPMP-PSATTTPLKA-- 477
            :|..:       |..:.:....:.|:......|....||::    :..:.:| |:.|..|..:
Human   764 FLLEQGTPSDILGMLKSLHQLQVENRRLEEQIKNLTAKKERLQLLNAQLSVPFPTITANPSPSHQ 828

  Fly   478 -------DGPPAKRARTARTPRVRKT--KDGSTPTKKRLAQIDSVLDDVQNGESL-------TMA 526
                   ..|......::::|.:..:  .|.|.|...:        |...:|:|.       |..
Human   829 IHTFSAQTAPTTDSLNSSKSPHIGNSFLPDNSLPVLNQ--------DLTSSGQSTSSSSALSTPP 885

  Fly   527 PVSVSHSQQ----QQQQQIQHSITTLAPSTPSQPQHQLQTLPSLDFSGMI---LPGGAQLALAN- 583
            |...|.:||    ...||: :.:|..|.::..||  ...|:|::...|.|   |||. |||:..
Human   886 PAGQSPAQQGSGVSGVQQV-NGVTVGALASGMQP--VTSTIPAVSAVGGIIGALPGN-QLAINGI 946

  Fly   584 PGATSSVGLQRGPATPNGQPAPPTTTLIYSNQLELQQALLQQQLQGQSIMIQDQAGNLVPLQLDG 648
            .||.:  |:.:.|.|.:..|.|.|
Human   947 VGALN--GVMQTPVTMSQNPTPLT----------------------------------------- 968

  Fly   649 TQAIYTTAPQAQRQQTTATYQTTQQQQQQPAQQPAGQAQQQPHYELDNVTYLSSTAAATPTSAEQ 713
                :||.|........||                                |:::|:.....::|
Human   969 ----HTTVPPNATHPMPAT--------------------------------LTNSASGLGLLSDQ 997

  Fly   714 QQQ----QQQQQHVIGTVQSYQILTPDGLQNFQPKLETAELGDLCPYSQYTFTTHAGAQPTLNAN 774
            |:|    |||.|.::.:.|    |||:
Human   998 QRQILIHQQQFQQLLNSQQ----LTPE-------------------------------------- 1020

  Fly   775 ALDAQTQHQQH-HQQQQHHHQQQQHHQQTQLLQQQ-PFATHHNPHQQFMELKNELLIKGGDAYTL 837
                  |||.. :|..||||||   |.|.:|.|.| |..|.       :.:.|  |:.|..|..|
Human  1021 ------QHQAFLYQLMQHHHQQ---HHQPELQQLQIPGPTQ-------IPINN--LLAGTQAPPL 1067

  Fly   838 DTAS 841
            .||:
Human  1068 HTAT 1071

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
seq	NP_001027415.1	C2H2 Zn finger	404..430	CDD:275370	4/25 (16%)
MLLT10	XP_024303947.1	PHD_AF10_AF17	24..71	CDD:277049
		RanBP2-type Zn finger	66..85	CDD:275375
		ePHD_AF10	78..206	CDD:277178
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900