DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment seq and JADE1

DIOPT Version :9

Sequence 1:	NP_001027415.1	Gene:	seq / 3772396	FlyBaseID:	FBgn0028991	Length:	882	Species:	Drosophila melanogaster
Sequence 2:	XP_024309986.1	Gene:	JADE1 / 79960	HGNCID:	30027	Length:	857	Species:	Homo sapiens

Alignment Length:	760	Identity:	126/760 - (16%)
Similarity:	220/760 - (28%)	Gaps:	306/760 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   277 EDDDENGMLHVKYEEQS---------LEHDPENE--------------HDAEQEHEYEEYQVIKA 318
            ||.|:||.|...:.:.|         ..|:....              ||:.|.:. :||.|:..
Human    26 EDSDDNGSLSTTWSQNSRSQHRRSSCSRHEDRKPSEVFRTDLITAMKLHDSYQLNP-DEYYVLAD 89

  Fly   319 EVEAE-----AAELAAGT----TSYTISQEQTGSGNTVLSSMVPKS---GSAAAAKQKRKRKTRV 371
            ....|     ...::.||    .:..:|:|::      |..:.||.   .|.:...:......|.
Human    90 PWRQEWEKGVQVPVSPGTIPQPVARVVSEEKS------LMFIRPKKYIVSSGSEPPELGYVDIRT 148

  Fly   372 IAD--------DEQGEYLE-------KMSVRGLDIARYEHIID--------------------GV 401
            :||        |....:||       :|.:..||....|.:::                    |:
Human   149 LADSVCRYDLNDMDAAWLELTNEEFKEMGMPELDEYTMERVLEEFEQRCYDNMNHAIETEEGLGI 213

  Fly   402 AY-----CLVCAKNDIFKTFKNKYSFQRHAYLFHEGQNRKIFACPICNKEFSRPDKMKMHKKDKH 461
            .|     |.||...|                  .|..|..:| |..||        :.:|:. .:
Human   214 EYDEDVVCDVCQSPD------------------GEDGNEMVF-CDKCN--------ICVHQA-CY 250

  Fly   462 GDVPMP--------------PSATTTPLKADGPPAKRARTARTPRVRKTKDGSTPTKKRLAQIDS 512
            |.:.:|              |.....|.|...             ::.|:.|:     :...:..
Human   251 GILKVPEGSWLCRTCALGVQPKCLLCPKKGGA-------------MKPTRSGT-----KWVHVSC 297

  Fly   513 VL--DDVQNGESLTMAPVS-VSH------------SQQQQQQQIQHSI----------------- 545
            .|  .:|..|....|.|:: |||            ..::....||.|:
Human   298 ALWIPEVSIGSPEKMEPITKVSHIPSSRWALVCSLCNEKFGASIQCSVKNCRTAFHVTCAFDRGL 362

  Fly   546 ---TTLAPSTPSQ-----PQHQLQTLPSLDFSGMILPGGAQLALANPGATSSVGLQRGPATPNG- 601
               |.||.:...:     |:|.....|.                      .|:|  :|.|..||
Human   363 EMKTILAENDEVKFKSYCPKHSSHRKPE----------------------ESLG--KGAAQENGA 403

  Fly   602 ------QPAPPTTTL-------------------------IYSNQLELQQAL------------- 622
                  .|..|..:|                         .:.|.|::.:||
Human   404 PECSPRNPLEPFASLEQNREEAHRVSVRKQKLQQLEDEFYTFVNLLDVARALRLPEEVVDFLYQY 468

  Fly   623 --LQQQLQGQSIMI---QDQAGNLVPLQLD---GTQAIYTTAPQAQRQQTTATYQTTQQQ----- 674
              |::::.....:|   :|:..||...:.|   ....::|...|...:....||..|:::
Human   469 WKLKRKVNFNKPLITPKKDEEDNLAKREQDVLFRRLQLFTHLRQDLERVRNLTYMVTRREKIKRS 533

  Fly   675 ----QQQ---------PAQQPAGQAQQQPHYELDNVTYLSSTAAA--TPTSAEQQQQQQQQQHVI 724
                |:|         ..::.:|.........|:|:...:|.:..  .|...:.:......:..:
Human   534 VCKVQEQIFNLYTKLLEQERVSGVPSSCSSSSLENMLLFNSPSVGPDAPKIEDLKWHSAFFRKQM 598

  Fly   725 GTVQSYQILTP---DGLQNF----------QPKLETAELGDLCPYSQYTFTTHAGAQPTL-NANA 775
            ||...:.:..|   |.|||.          ||.|.....|.:.|.|      ..|.:.|. .|..
Human   599 GTSLVHSLKKPHKRDPLQNSPGSEGKTLLKQPDLCGRREGMVVPES------FLGLEKTFAEARL 657

  Fly   776 LDAQTQHQQHHQQQQHHHQQQQHHQQTQL----LQQQPFATHHNP 816
            :.||   |::......|.:::.:.....|    |:.:.|...|.|
Human   658 ISAQ---QKNGVVMPDHGKRRDNRFHCDLIKGDLKDKSFKQSHKP 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
seq	NP_001027415.1	C2H2 Zn finger	404..430	CDD:275370	4/25 (16%)
JADE1	XP_024309986.1	EPL1	114..>544	CDD:331339	79/505 (16%)
JADE1	XP_024309986.1	ePHD_JADE1	270..387	CDD:277174	21/134 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900