DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment seq and kdm4c

DIOPT Version :9

Sequence 1:	NP_001027415.1	Gene:	seq / 3772396	FlyBaseID:	FBgn0028991	Length:	882	Species:	Drosophila melanogaster
Sequence 2:	NP_001077320.1	Gene:	kdm4c / 570194	ZFINID:	ZDB-GENE-070209-38	Length:	1482	Species:	Danio rerio

Alignment Length:	885	Identity:	151/885 - (17%)
Similarity:	279/885 - (31%)	Gaps:	278/885 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 TTASSPQ-QQQQQQQQQQNVATSV-----ADNVVTTISSSSILHTNANTNGVDTLAATQQQQQQQ 157
            |.:::|: |...|:::::..:||:     ....:.|:.|:.:..:...:.   :.|.|.:.::::
Zfish   349 TPSTTPELQSWLQRRRRKTPSTSLHAPRSCSKRLKTVDSAPVKGSGRRSR---SAALTAKNKEEE 410

  Fly   158 QQQQQQQQQQHYHYITTTGEDGQTPTTIVFENYNGGMPAVSS-----------AAPTPVPVSQAN 211
            ::...:.|::..:.....|..|:....:........:.|.|:           ..||....|..|
Zfish   411 EEDPVKHQKESQYSSELKGLAGRQMCVVKVTRVESDLLAQSTRQVKEASPERLLTPTLTTTSSQN 475

  Fly   212 AP---ATTTTTALVNTDGTIIEFDGSTYEEYHVLKSEPGSSDCLSNGSSAVAADIIKYDPQHGVV 273
            .|   .|::.|:|:..:|.:.:...||      .:|||.|:     ..|.:..|:        .:
Zfish   476 DPDVGHTSSQTSLILDEGQVSKNTNST------AQSEPEST-----SESDIIVDV--------TL 521

  Fly   274 GDEEDDDENGMLHVKYEEQSLEHDPENEHDAEQEHEYEEYQVIKAEVEAEAAELAAGTTSYTISQ 338
            |.|..        .|...|:|..:                         ...|..|.:...|.|.
Zfish   522 GSERT--------AKNPNQTLNCE-------------------------SVLETIAPSIPVTHSL 553

  Fly   339 EQTGSGNTVLSSMVPKSGSAAAAKQKRKRKTRVIADDE-----QGEYLEKMSVRGLDIARYEHII 398
            ....:|.|||.|   :|.|..|..:..:.....:.:|.     ...|.|:.|: .||.|     :
Zfish   554 TLHSTGATVLFS---ESDSQQAKIETEETVIDTLTEDSIDCGTSALYKEQSSI-SLDPA-----L 609

  Fly   399 DGVAYCLVCAKNDIFKTFKNKYSFQRHAYLFHEGQNRKIFACPICNKEFSRPDKMKMHKKDKHGD 463
            .|                 ::.|..|        .|.:|...|.|......|:.:: .:.:....
Zfish   610 QG-----------------SEPSMNR--------TNSEIQTTPFCEMPLLMPELIE-ERVNPQCL 648

  Fly   464 VPMPPSAT--------------TTPL----KADGPPAKRARTARTPRVRKTKDGSTP------TK 504
            .|..||.|              :.|:    |:..||      ..|..||...:.:.|      .|
Zfish   649 APEMPSLTLAIRPDSANHQPYNSAPILHLEKSHSPP------VITDEVRGCSERACPDWPFILPK 707

  Fly   505 KRLAQIDSVLDDVQNGESLTMAPVSVS-----------------HSQQQQQQQIQH-SITTLAPS 551
            :.::|....:.|     |....|.|.|                 |......|..|| ||:..  :
Zfish   708 EGVSQSHKSISD-----SFKAKPTSASFAPQWGTPEESKQEGNIHKCTSTDQNTQHESISNC--T 765

  Fly   552 TPSQPQHQLQTLPSLDF--SGMILPGGAQLALANPGATSSVGLQRGPATPNGQPAPPTTTLIYSN 614
            ||::...|......:||  |.|:...|.:.:......:||:...:.    |...:.|.|  |:.|
Zfish   766 TPTRSILQSSATTHMDFIDSKMVEGVGKETSQRIEEQSSSLTSSQS----NFAESKPFT--IWKN 824

  Fly   615 QLELQQALLQQQLQGQSIM--------------IQDQAG--------------------NL--VP 643
            ......|:|.:.||.:.::              :..::|                    ||  :|
Zfish   825 LSSDNPAVLIESLQPELVVGLTADYAHDSLPYTMWSESGCQQEKFSDSPNSSPHTQTWTNLEPIP 889

  Fly   644 LQLDGTQAIYTTAPQAQRQQTTATYQTTQQQQQQPA------QQPAGQAQQQPHYEL-------- 694
            :|...|: :...||...:|         :.::.:||      :|...|..|:..:::
Zfish   890 MQCSDTE-VSENAPLDLKQ---------ENEEVEPAEACELNEQAGSQEPQEREFKIQEYYRSVK 944

  Fly   695 --------DNVTYLSSTAAATPTSAEQQQQQQQQQHVIGTVQSYQILTPDGLQNFQPKLETAELG 751
                    |:.:..|....|..:|...::........:.|          ||          |.|
Zfish   945 SEHDGSVSDSDSCESGDKGADSSSESSEENPMSDPEYVET----------GL----------EPG 989

  Fly   752 DLCPYSQYTFT------THAGAQPTLNANALDAQTQHQQHHQQQQHHHQQQQHHQQTQLLQQQPF 810
            ::|.|...|..      .|...:||  |.|:.:..:.|.....:.......:..:.......:|.
Zfish   990 EVCTYHMQTVKKTAKSWRHPLRKPT--ARAVPSAVKQQAASDDEVIEECASEEDEPETEEWAKPL 1052

  Fly   811 A---THHNPHQQFMELKNELLIKGGDAYTLDTASM-YHLP 846
            .   .|...|.|:.:..|....|......:.|..| ||.|
Zfish  1053 VHLWQHRKAHFQYEQEYNMTAAKNAPHCAVCTLFMPYHQP 1092

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
seq	NP_001027415.1	C2H2 Zn finger	404..430	CDD:275370	2/25 (8%)
kdm4c	NP_001077320.1	JmjN	16..57	CDD:128818
		JmjC	177..293	CDD:202224
		PHD_SF	1079..1176	CDD:304600	5/14 (36%)
		ePHD_JMJD2C	1185..1294	CDD:277185
		TUDOR	1308..1364	CDD:197660
		TUDOR	1366..1421	CDD:197660
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900