DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment seq and mllt10

DIOPT Version :9

Sequence 1:	NP_001027415.1	Gene:	seq / 3772396	FlyBaseID:	FBgn0028991	Length:	882	Species:	Drosophila melanogaster
Sequence 2:	XP_017209395.2	Gene:	mllt10 / 492342	ZFINID:	ZDB-GENE-041114-176	Length:	1162	Species:	Danio rerio

Alignment Length:	1012	Identity:	183/1012 - (18%)
Similarity:	298/1012 - (29%)	Gaps:	379/1012 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KIPKLSQTSAATGGATAAAEASTSKSSQGQQQQIVYVNMLPAANTLNGIPQQQQQQQYASTDGNV 74
            ::|..|.:|:..||      :|..|||..:                    .::.....:|:.|:
Zfish   366 EVPPHSSSSSKDGG------SSDGKSSDSK--------------------SKKSSHSTSSSSGS- 403

  Fly    75 YQLQNEILCDANGHAVTAATASYQTTASSPQQQQQQQQQQQNVATSVADNVV------TTISSSS 133
             :.:..:....:|..||.||:|...:::||.||........:..::.:.:||      .:.|..|
Zfish   404 -RGRKSVAGKPHGPVVTTATSSTAPSSTSPFQQGHLLGSNSSSKSATSGSVVQPTSDFLSFSDPS 467

  Fly   134 I---------------LHTNANTNGVDTLAATQQ-QQQQQQQQQQQQQQQHYHYITTTGEDGQTP 182
            :               :...|.:...:::.|... ......|.......:||....||||
Zfish   468 LRAGDSYTPPSFGRCHMKGGAESGASESMVALNTFSMIPLSQSSSSSSSKHYENCHTTGE----- 527

  Fly   183 TTIVFENYNGGMPAVSSAAPTPVPVSQANAPATTTTTALVNTDGTIIEFDGSTYEEY-------- 239
                    .|.:.:.|...|.|     :::.::.|:::....||...:..|:....|
Zfish   528 --------LGSLASASYKRPQP-----SSSSSSATSSSSTGEDGVKKKKRGNWRNRYGPCFTTQD 579

  Fly   240 --------HVLKSEPGSSDCLSNGSSAVA-ADIIKYDPQHGVVGDEEDD---------DENGMLH 286
                    |:......:|...|:.|:.|. ...:......|.||.....         ..||.|
Zfish   580 SKTTDAGEHISTMPSSTSPSPSSMSNMVCRGSTVSSTASVGAVGAGTSSLGIQKSPSLLRNGSL- 643

  Fly   287 VKYEEQSLEHDPENEHDAEQEHEYEEYQ---------VIKAEVEAEAAELAA------------- 329
                 |.:..........||:..|....         |:...:.|..:||.|
Zfish   644 -----QGMTVSSPPAVPGEQKRSYPSSSDVACPLPSAVLGGSMSASNSELPAHQSVVVTSMPTLT 703

  Fly   330 --------GTTSYTISQEQTGSGNTVLSSMV-----PKSGSAAAAKQKRKRKTRVIADDEQGEYL 381
                    .:|..|.:....||.|...|.|.     |.|..||...|.....    ||.|.|:..
Zfish   704 SLPSAAPFTSTPSTHANSLPGSFNLAPSHMFGNRLNPNSAMAALIAQSEGSP----ADQELGDGA 764

  Fly   382 EKMSVR---------------GLDIARYE--HIIDGV---AYCLVCAKNDIFKTFKNKYSFQRHA 426
            ...|.|               ||.| ||:  .::.|:   :..|..|...|.:..:.::: :...
Zfish   765 LGFSRRGNSPKTNLSPRSPLSGLHI-RYDAGPMVPGLGSGSDTLPPAATSIDQLLERQWN-EGQQ 827

  Fly   427 YLFHEGQNRKIFA-------CPICNKEFSRPDKMKMHKKDK------HGDVPMPPSATTTPLKAD 478
            :|..:|....:.|       ..:.|:......:....||::      ...||..|::||
Zfish   828 FLLQQGSQGDVLAMLKSLHQLQVENRRLEEQIRTLTMKKERLQLLSAQLSVPFTPASTT------ 886

  Fly   479 GPPAKRARTARTPRVRKTKDGSTPTKKRLAQIDSVLDDVQNGESL-TMAPVSVSHSQQQQQQQIQ 542
                  |.||.:|.............|.: |:.|||  .::.:.| |..|.|..||......
Zfish   887 ------ATTASSPMYPSNTHTDMLHSKSI-QLGSVL--TESSQPLPTQDPQSGGHSSGSSTS--- 939

  Fly   543 HSITTLAPSTPSQPQHQLQTLPSLDFSGM-ILPGGAQLAL-ANPGATSSVGLQRG---------- 595
             |::|...:..|.||.|:.   .:..:|: :.||.|..:| |..|.|..:|..:|
Zfish   940 -SLSTPPSAAHSPPQQQVN---GVGMAGVPVQPGNANSSLPAIAGVTGLMGALQGNHLAMSGIVG 1000

  Fly   596 -----------PATPNGQPAPPTTTLIYSNQLELQQALLQQQLQGQSIMIQDQAGNLVPLQLDGT 649
                       ..|.|..|.|.:.| ..|..|.:..:|....:
Zfish  1001 ALNGVIQTSQSSLTQNSSPLPQSAT-ASSASLSMSSSLTNSSM---------------------- 1042

  Fly   650 QAIYTTAPQAQRQQTTATYQTTQQ-----------QQQQPAQQPAGQAQQQPHYELDNVTYLSST 703
                         .||.|...|:|           ||...:|||..:.||...|:|
Zfish  1043 -------------STTKTRLFTEQHRQILLHQHQLQQLFGSQQPTPEQQQVLLYQL--------- 1085

  Fly   704 AAATPTSAEQQQQQQQQQHVIGTVQSYQILTPDGLQNFQPKLETAELGDLCPYSQYTFTTHAGAQ 768
                    .|||||||||.....:|..|:                .:..|.|          |.|
Zfish  1086 --------MQQQQQQQQQQQQNDIQFQQL----------------PINSLLP----------GNQ 1116

  Fly   769 PTLNANALDAQTQHQQHHQQQQHHHQQQQHHQQTQLLQQQPFATHHNPHQQFMELKNELLIKGGD 833
            ||.:.|                                  ||..|||.:.
Zfish  1117 PTTSTN----------------------------------PFLAHHNDNN--------------- 1132

  Fly   834 AYTLDTASMYHLPFSPTSMINAVNDVNTSSLLETKEI 870
                          :|.:      .|||:::.:||.:
Zfish  1133 --------------TPKA------GVNTAAIKQTKRL 1149

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
seq	NP_001027415.1	C2H2 Zn finger	404..430	CDD:275370	4/25 (16%)
mllt10	XP_017209395.2	PHD_AF10_AF17	50..97	CDD:277049
mllt10	XP_017209395.2	ePHD_AF10	148..273	CDD:277178
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900