DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment seq and ttk

DIOPT Version :9

Sequence 1:	NP_001027415.1	Gene:	seq / 3772396	FlyBaseID:	FBgn0028991	Length:	882	Species:	Drosophila melanogaster
Sequence 2:	NP_001189329.1	Gene:	ttk / 48317	FlyBaseID:	FBgn0003870	Length:	813	Species:	Drosophila melanogaster

Alignment Length:	734	Identity:	168/734 - (22%)
Similarity:	265/734 - (36%)	Gaps:	203/734 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 SAATGGATAAAEASTSKSSQGQQQQIVYV---------NMLPAANTLNGIPQQQQQQQYAST--- 70
            :||..||.|....||:.:.|.|:.|...|         .:|.:|......|....|....|:
  Fly   127 AAAAAGAGATGSESTATTPQLQRIQPYLVPQRNRSQAGGLLASAANAGNTPTLPVQPSLLSSALM 191

  Fly    71 -----------------DGNVY-------------QLQNEILCDAN---------------GHA- 89
                             .||.|             .|.|..:|:.:               ||.
  Fly   192 PKRKRGRPRKLSGSSNGTGNDYDDFDRENMMNDSSDLGNGKMCNESYSGNDDGSDDNQPNAGHTD 256

  Fly    90 -VTAATASYQTTASSPQQQQQQQQQQQNVATSVADNVVT-----TISSSSILHTNANTNGVDTLA 148
             :..:..|..:..|...:..:.....::.:|||.....|     .:..||....:|...|..:..
  Fly   257 DLNESRDSLPSKRSKNSKDHRVVSHHEDNSTSVTPTKATPELSQRLFGSSSTTISATAPGGSSTG 321

  Fly   149 ATQQQQQQQQQQQQQQQQQHYHYI----------TTTGEDG--QTPT----------------TI 185
            .::.....:...:::....|...|          ||..:.|  ||||                ::
  Fly   322 PSETISLLEISDERESAPVHLPTILGLKIRAINTTTPAQQGSPQTPTKSKPKIRQATGSNNSNSL 386

  Fly   186 VFENYNGGMPAVSSAAPTPVPVSQANAPAT-----TTTTALVNTDGTIIEFDGSTYEEYHVLKSE 245
            :.:...||      |....||      |||     .|..|.:|.:....|......:|.:.
  Fly   387 LKQQLRGG------AKDPEVP------PATRITGAVTPNAALNAEEQSKEMPKKNQDEVNA---- 435

  Fly   246 PGSSDCLSNGSSAVAADIIKYDPQHGVVGDEEDDDENGMLHVK-----------YEEQSLE---- 295
                 |:...|.|.||     :.|...|....:.....:||:.           |::|..|
  Fly   436 -----CIGLHSLANAA-----EQQAAQVASTGNLHHQLLLHMAANNSMLNTTDYYQQQQQESPSS 490

  Fly   296 --------------HDPENEHDAEQEHEYEEYQVIKAEVEAEAAELAAGTTSYTISQEQTGSGNT 346
                          :|.:::.| |.:||    .|..|:..|............|.:||.:.:..|
  Fly   491 AGQFMDDDLELLSLNDQQDKSD-EPDHE----MVTLADENAGLPGYQGNEAEATPAQEDSPAAET 550

  Fly   347 VLS-SMVPKSGSAAAAKQKRKRKTRVIAD---DEQGEYLEKMSVRGLDIARYEHIIDGVAYCLVC 407
            ..: ...|:||...|.:..::|:.|..|.   |:|.|:|.:|||||||:.||..:::||..|..|
  Fly   551 ATAPPPAPRSGKKGAKRPIQRRRVRRKAQSTLDDQAEHLTEMSVRGLDLFRYASVVEGVYRCTEC 615

  Fly   408 AKNDIFKTFKNKYSFQRHAYLFHEGQNRKIFACPICNKEFSRPDKMKMHKKDKHGDVPMPPS-AT 471
            ||.::.|||||||||||||:|:|||::||:|.||:|:||||||||||.|.|..|.:...|.. ..
  Fly   616 AKENMQKTFKNKYSFQRHAFLYHEGKHRKVFPCPVCSKEFSRPDKMKNHLKMTHENFTPPKDIGA 680

  Fly   472 TTPLKADGPPAKRARTARTPRVRKTKDGSTPTKKRLAQIDSVLDDVQNGESLTMAPVSVSHSQQQ 536
            .:|||.....|.......|...::.........::|.|.::..|  ....||.:..|.:.|::.|
  Fly   681 FSPLKYLISAAAAGDMHATIYQQQQDHYHRQLAEQLEQQNASFD--SRDSSLILPDVKMEHAEDQ 743

  Fly   537 QQQQIQHSITTLAPSTPSQPQHQLQTLPSLDFSGMILPGGAQLALANPGATSS--VGLQRG---- 595
            ..:|                            ...:..||..  .:||.|.::  :.||:.
  Fly   744 DAEQ----------------------------EAELSDGGYD--ASNPAAAAAAMLSLQQDVIIK 778

  Fly   596 ---PATPNGQPAPPTTTLI 611
               ..:|:..|.||.:..:
  Fly   779 DEIQISPSPSPTPPASCAV 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
seq	NP_001027415.1	C2H2 Zn finger	404..430	CDD:275370	18/25 (72%)
ttk	NP_001189329.1	BTB	23..119	CDD:279045
		BTB	34..119	CDD:197585
		C2H2 Zn finger	612..638	CDD:275370	18/25 (72%)
		zf-C2H2_4	646..669	CDD:290605	16/22 (73%)
		C2H2 Zn finger	648..669	CDD:275370	15/20 (75%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438887
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.930