DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment seq and MLLT6

DIOPT Version :9

Sequence 1:	NP_001027415.1	Gene:	seq / 3772396	FlyBaseID:	FBgn0028991	Length:	882	Species:	Drosophila melanogaster
Sequence 2:	NP_005928.2	Gene:	MLLT6 / 4302	HGNCID:	7138	Length:	1093	Species:	Homo sapiens

Alignment Length:	956	Identity:	171/956 - (17%)
Similarity:	292/956 - (30%)	Gaps:	323/956 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 QQSRKFEGKI----------PKLSQTSAATGGATAAAEASTSKSSQGQQQQIVYVNMLPAANTLN 56
            :.||:.:||.          .|||.....:...:|::.:|:|.||.|...|       ||.::|.
Human   293 ESSRESKGKKSSSHSLSHKGKKLSSGKGVSSFTSASSSSSSSSSSSGGPFQ-------PAVSSLQ 350

  Fly    57 GIP--------QQQQQQQYASTDGNVYQLQNEILCDANGHAVTAATASYQTTASSPQQQQQQQQQ 113
            ..|        :|.::.:|:..                    ||...|...:.|:|:..:....:
Human   351 SSPDFSAFPKLEQPEEDKYSKP--------------------TAPAPSAPPSPSAPEPPKADLFE 395

  Fly   114 QQNVATSVADNVVTTISSSSILHTNANTNGVDTLAATQQQQQQQQQQQQQQQQQHYHYITTTGED 178
            |:.|.:.....:..:.::||.....|.:.|                   ..:..|   :|.:|..
Human   396 QKVVFSGFGPIMRFSTTTSSSGRARAPSPG-------------------DYKSPH---VTGSGAS 438

  Fly   179 GQTPTTIVFENYNGGMPAVSSAAPTPVPVSQANAPATTTTTALV--------------------- 222
            ..|         :..|||:|:   ||||..:      |..|.|.
Human   439 AGT---------HKRMPALSA---TPVPADE------TPETGLKEKKHKASKRSRHGPGRPKGSR 485

  Fly   223 NTDGTIIEFDGSTYEEYHVLKSEPGSSDCLSNGSSAVAADIIKYDPQHGVVGDEEDDDENGMLHV 287
            |.:||     |.        .:.|........|.:|.||     .|..|  |........|:
Human   486 NKEGT-----GG--------PAAPSLPSAQLAGFTATAA-----SPFSG--GSLVSSGLGGL--- 527

  Fly   288 KYEEQSLEHDPENEHDAEQEHEYEEYQVIKAEVEAEAAELAAGTTSYTISQEQTGSGNTVL---- 348
                .|....|...               ...:..|:..|.||.  ||.:::.......:|
Human   528 ----SSRTFGPSGS---------------LPSLSLESPLLGAGI--YTSNKDPISHSGGMLRAVC 571

  Fly   349 -----SSMVPKSGSAAAAKQKRKRKTRVIADDEQGEYLEKMSVRGLDIARYEHIIDGVAYCLVCA 408
                 ||::...|::|..:..|...|..:......                            .:
Human   572 STPLSSSLLGPPGTSALPRLSRSPFTSTLPSSSAS----------------------------IS 608

  Fly   409 KNDIFKTFKNKYSFQRHAYLFHEGQNRKIFACPI---------CNKEFSRPDKMKMHKKDKHGDV 464
            ...:|....:.:|.          .:..||..|:         .....:.||......:.: |..
Human   609 TTQVFSLAGSTFSL----------PSTHIFGTPMGAVNPLLSQAESSHTEPDLEDCSFRCR-GTS 662

  Fly   465 PMPPSATTTPLKADGPPAKRARTARTPRVRKTKDGSTPTKKRLAQIDSVLDDVQNGESLTMAPVS 529
            |....::.:|:.:  .||...:||..|......|.:.|....:.|:.....|.:.|.:: :..:.
Human   663 PQESLSSMSPISS--LPALFDQTASAPCGGGQLDPAAPGTTNMEQLLEKQGDGEAGVNI-VEMLK 724

  Fly   530 VSHSQQQQQQQIQHSITTLAPSTPSQPQHQLQTLPSLDFSGMILPGGAQLALANPGATSSVGLQR 594
            ..|:.|::.|::|..|.:|     :..:.:||.|            ..||::..|...:::....
Human   725 ALHALQKENQRLQEQILSL-----TAKKERLQIL------------NVQLSVPFPALPAALPAAN 772

  Fly   595 GPATPNGQPAPPTTTLIYSNQLELQQALLQQQLQGQSIMIQDQAGNLVPLQLDGTQAIYTTAPQA 659
            || .|.....||                  |.....|:...........|.||.:.:..:..|.:
Human   773 GP-VPGPYGLPP------------------QAGSSDSLSTSKSPPGKSSLGLDNSLSTSSEDPHS 818

  Fly   660 ---QRQQTTATYQTTQQQ----QQQPAQQPAGQAQQQPHYELDNVTYLSSTAAATPTSAEQQQ-- 715
               .|..::.::.:|...    ||.||..|                 |:...|..|...:.|.
Human   819 GCPSRSSSSLSFHSTPPPLPLLQQSPATLP-----------------LALPGAPAPLPPQPQNGL 866

  Fly   716 ----------QQQQQQHVIGTVQSYQILTPDGLQNFQPKLETAELGDL------CPYSQYTFTTH 764
                      .....:.::|.:.....|..:||           ||.|      .|.|    .:.
Human   867 GRAPGAAGLGAMPMAEGLLGGLAGSGGLPLNGL-----------LGGLNGAAAPNPAS----LSQ 916

  Fly   765 AGAQPTLN-ANALDAQTQHQQHHQQQQHHHQQQQHHQQTQLLQQQPFATHHNP--HQQFMELKNE 826
            ||..|||. ...|::.|:.|:|..||    |:||..|..|||........|..  :|...:::.:
Human   917 AGGAPTLQLPGCLNSLTEQQRHLLQQ----QEQQLQQLQQLLASPQLTPEHQTVVYQMIQQIQQK 977

  Fly   827 -----LLIKGGDAYTLDTASMYHLPFSPTSMINAVNDVNTSSLLET 867
                 |.:.||.  .|..||:  |..|.|.:::|    .|..||.|
Human   978 RELQRLQMAGGS--QLPMASL--LAGSSTPLLSA----GTPGLLPT 1015

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
seq	NP_001027415.1	C2H2 Zn finger	404..430	CDD:275370	2/25 (8%)
MLLT6	NP_005928.2	PHD_AF10_AF17	7..54	CDD:277049
		ePHD_AF17	61..185	CDD:277179
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	185..500		51/286 (18%)
		Leucine-zipper	729..764		11/51 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	775..871		20/130 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1060..1093
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900