DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment seq and rno

DIOPT Version :9

Sequence 1:	NP_001027415.1	Gene:	seq / 3772396	FlyBaseID:	FBgn0028991	Length:	882	Species:	Drosophila melanogaster
Sequence 2:	NP_001246528.1	Gene:	rno / 38027	FlyBaseID:	FBgn0035106	Length:	3241	Species:	Drosophila melanogaster

Alignment Length:	1140	Identity:	209/1140 - (18%)
Similarity:	350/1140 - (30%)	Gaps:	405/1140 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 GKIP---KLSQTSAATGGAT--------AAAEASTSKSSQGQQQQIVYVNMLPAANTLNGIPQQQ 62
            ||.|   :.|::|||...:|        ....::||.||.|         .:.:.|:.:......
  Fly   797 GKNPTGRRASKSSAAAATSTHNKSQFHSNIRSSTTSHSSSG---------TISSGNSSSANGTSS 852

  Fly    63 QQQQYASTDGNVYQLQNEILCDANGHAVTAATAS------YQTTASSPQQQQQQQQQQQNVATSV 121
            ......|..|      :|....:.|..|:...:|      .|:.|.|.:|:|:|:|::||.|.:.
  Fly   853 SDSSSGSDSG------SESGSSSAGSGVSKRKSSSGSPLKKQSYARSVEQRQKQRQRRQNEAVAG 911

  Fly   122 ADNVVTTISSSSILHTNANTNGVDTLAATQQQQQQ-------QQQQQQQQQQQHYHYITTTGEDG 179
            |........|:|     ::::|.|.....:|:.::       |.:....:.|......||..:.|
  Fly   912 ASATYPDSRSAS-----SSSDGEDERCRNRQEPERGARRGPIQSKSVPNRSQASRSKPTTEADVG 971

  Fly   180 QTPTTIVFENYNGGMPAVSSAAPTPVPVSQANAPATTTTTALVNTDGTIIE-FDGSTYEEYHVLK 243
            :            |..|            .|....:|||..|...|....| ......||...|:
  Fly   972 E------------GTGA------------SARRKLSTTTRGLAQMDKDADESVSSDESEELLPLR 1012

  Fly   244 SEPGSSDCLSNGSSAVAADIIKYDPQHGVVGDEEDDDENGMLHVKYEEQSLEHDPENEHDAEQEH 308
            .|.......::|.:...:.|.:...|| :..|.|..                       .:|||.
  Fly  1013 GERQRESTTTSGLATTGSAIGRNLGQH-IYSDSESS-----------------------SSEQEK 1053

  Fly   309 EYEEYQVIKAEV-----------EAEAAELAAGTTSYTISQEQTGSGNT-VLSSMVPKSGSA--- 358
            :.||...:::.|           :|...|...||.:.|.|..|..|..: ..::...|.|:|
  Fly  1054 DQEEQATVESNVSDSQNQQTIRTKAAMKEFVPGTAATTSSTSQAASSTSKAKNTREGKEGAASIG 1118

  Fly   359 -------------------------AAAKQKRKRKTRVIADDEQGEYLEKMSVRGLDIARYEHII 398
                                     ||.|.....::..:|...|.:..::  ||..||    :.|
  Fly  1119 NSTKTKPNPNAKLYPADLLVVPQRQAAKKASENMRSTNLATTLQPDVSDR--VREPDI----NSI 1177

  Fly   399 DGVAYCLV-----CAKNDIFKTFKNKYSFQRHAYLFHEGQNRKIFACPICNKEFSRPDKMKMHKK 458
            .|.|...|     ...|:..|:...|...:.|   ..:...:...:.|....:..||.|:   .|
  Fly  1178 SGTAKSKVKDSSSRVSNEADKSSLEKVRPKEH---LQKTVGKTSESAPAERGKRGRPPKV---PK 1236

  Fly   459 D------KHGDVP--------MPPSATTTPLKADGPPAKRARTARTPRVRKTKDGSTPTK--KRL 507
            |      ...|.|        .|||...||:.|....|    .:..|:.:..|..:...|  |.:
  Fly  1237 DARPPSITENDKPALPTHTQSKPPSVVATPVSAKSNFA----VSLVPQRQAAKKAAEQLKSSKPV 1297

  Fly   508 AQIDSVLDDVQNGESLTMAPVSVSHSQ----QQQQQQIQHSITTLAPSTPSQP------------ 556
            .:..|..:|:.:.|::|.|.:|.|.|.    ....:..:.|....||.||.:|
  Fly  1298 LESFSTGNDISDKETVTSATISGSGSSVPAASTPVKPTRRSSIKEAPITPKEPLSGRRKSKEDLL 1362

  Fly   557 QHQLQTLP-----------------------SLDFSGMILPGGAQ-------------------- 578
            ...::|.|                       |...||.....|..
  Fly  1363 ATPIKTTPLVKRRVVVPNLSSSSSGDSESSSSSSSSGSSSSSGGSDSDSESQASNSENPSSREPP 1427

  Fly   579 LALANPGATSSVGLQRGPATPNGQP-----APPTTTLI-------------YSNQLELQQALLQ- 624
            :|.|...:.||:..:|.|.....:|     ||.:..::             .|.::.||:|:..
  Fly  1428 VAPAKVPSDSSLVPKRSPRKSMDKPSALTIAPASVNVLNIPSTRSRQNSTTKSTKVALQKAVQSV 1492

  Fly   625 ----------QQLQGQSIMIQDQAGNLVPLQLDGTQAIYTTAPQAQRQQTTATYQTTQQQQQQPA 679
                      .:|||.    .|:.|..|.|:                   .||.:.|:..:.:|
  Fly  1493 EDDVKCTPKTNRLQGS----MDECGKQVQLE-------------------QATKRATRGSKSRP- 1533

  Fly   680 QQPAGQAQQQPHYELDNVTYLSSTAAATPTSAEQQQQQQQQQHVI---GTVQSYQIL-------- 733
              |:..|:..|.   ..|:...|.|..:|......:|:..|:.|.   ||....::|
  Fly  1534 --PSPTAKSSPE---KTVSRCKSRAEESPKKVANLEQEISQRKVASGKGTSSLDKLLNKKQQQMN 1593

  Fly   734 -----TPDGLQNFQPKLET------------------------------------AELGDLCPYS 757
                 ||..:....|..||                                    ||.|:|....
  Fly  1594 HSAQATPPPISPTPPASETRIVKDQCDLKPDEVSIQQINLGADAQPEPDLDPESAAEAGELPMDI 1658

  Fly   758 QYTFTT-------HAGAQ-----------------------PTLNANALDA--------QTQHQQ 784
            ....||       .|.|.                       ||.|....||        :.:.:.
  Fly  1659 DEELTTAPTRTQLSASASKLADIIDDERPPAAPLPASPTPTPTSNDEMSDAGSDLSERRRMRWRS 1723

  Fly   785 HHQQQQHHHQQQQHHQQTQLLQQQPFATHHNPH-----QQFMEL----KNELLIKGGDAYTLDTA 840
            ..::::..|:..:.|            |||..|     :...||    ||||| .....|:..|:
  Fly  1724 RRRRRRRSHEPDEEH------------THHTQHLLNEMEMARELEEERKNELL-ANASKYSASTS 1775

  Fly   841 S--MYHLPFSPTSMINAVNDVNTSSLLETKEISYD 873
            |  :..:|..|..:|    :::::|..:.::..:|
  Fly  1776 SPAVTVIPPDPPEII----ELDSNSAEQQQQHLHD 1806

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
seq	NP_001027415.1	C2H2 Zn finger	404..430	CDD:275370	5/30 (17%)
rno	NP_001246528.1	COG5141	250..>664	CDD:227470
		EPL1	<250..288	CDD:287484
		PHD_JADE	314..359	CDD:277048
		ePHD_RNO	367..480	CDD:277177
		TFIIA	2138..>2295	CDD:281188
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5141
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900