DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment seq and Mllt10

DIOPT Version :9

Sequence 1:	NP_001027415.1	Gene:	seq / 3772396	FlyBaseID:	FBgn0028991	Length:	882	Species:	Drosophila melanogaster
Sequence 2:	XP_038951869.1	Gene:	Mllt10 / 361285	RGDID:	1310874	Length:	1068	Species:	Rattus norvegicus

Alignment Length:	922	Identity:	182/922 - (19%)
Similarity:	290/922 - (31%)	Gaps:	311/922 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 PQQQQQQQQQQQNV--ATSVADNVVTTISSSSI------------LHTNANTNGVDTLAATQQQQ 154
            |:.::|.:.....|  .|...:...|:.|::||            ..||||...|....::.:..
  Rat   243 PKHKKQPEPSPALVPSLTVTTEKTYTSTSNNSISGSLKRLEDTAARFTNANFQEVSAHTSSGKDV 307

  Fly   155 QQQQQQQQQQQQQHYHYITTTGEDGQTPTTIVFENYNGGM---PAVSSAAP--------TPVPVS 208
            .:.:.:.:.::...:    ::|:.|:.|        .||.   ..||:::|        ||..|.
  Rat   308 SEARSEGKGKKSSAH----SSGQRGRKP--------GGGRNPGTTVSASSPFPQGSFSGTPGSVK 360

  Fly   209 QANAPATTTTTALVNTDGTIIEFDGSTYEE-----YHVLKSEPGSSDCLSN---------GSSAV 259
            .::..:..:....::...:.:..|..|:.:     ..|.|.||||.|...|         |:|..
  Rat   361 SSSGSSVQSPQDFLSFTDSDLRNDSYTHTQPPPSTKDVHKGEPGSQDAGVNSFSSLVGHPGTSGA 425

  Fly   260 AADIIKYDPQHGVVGDE---------------EDDDENGMLHVKYEEQSLEHDPENEHDAEQEHE 309
            .:....:|...|.:|..               |:::.......|..:|| :|.|......:.:..
  Rat   426 TSQPKSFDSSPGELGSSSLPTAGYKRAQTSGVEEEEAVKEKKRKGNKQS-KHGPGRPKGNKNQEN 489

  Fly   310 YEEYQVIKAEVEAEAAELAAGTTSYTISQEQTGSGNTVLSSMVPKSGSAAAAKQKRKRKTRVIAD 374
            .....|..|...:..|..|...||.::.:..|...|..:.|:  ..||
  Rat   490 VSHLSVSSASPTSSVASAAGSVTSCSLQKSPTLLRNGSMQSL--SVGS----------------- 535

  Fly   375 DEQGEYLEKMSVRGLDIA-RYEHIIDGVAYCLVCAKNDIFKTFKNK-YSFQRHAYLFHEGQNRKI 437
                      |..|.:|: :|.|  ||.  |.....:::.....|. |:....|..|....:...
  Rat   536 ----------SPLGSEISMQYRH--DGA--CPTTTFSELLNAIHNGIYNSNDVAVSFPNVVSGSG 586

  Fly   438 FACPICNKEFSRPDKMKMHKKDKHGDVPMPPSATTTPLKADGPPAKRARTARTPRVRKTKDGSTP 502
            .:.|:.:...                    |..::..|:..|..:..|.::.||....|:..:.|
  Rat   587 SSTPVSSSHI--------------------PQQSSGHLQQVGALSPSAASSVTPAAATTQANTAP 631

  Fly   503 TKKRLAQIDSVLDDVQNGESLTMAPVSVSHSQQQQQQQIQHSITTLAPSTPSQPQHQLQTLPSLD 567
                             |.||:.||..|..|:..|...:   ...:|.|..||....|
  Rat   632 -----------------GSSLSQAPAHVYGSRLNQNPSM---AVLIAQSESSQTDQDL------- 669

  Fly   568 FSGMILPGGAQLALANPGATSSVGLQRGPATPNG----------QPA-------PPTTTLIYSNQ 615
                   |....:|...|::     .||..:|..          ||:       ||....|  .|
  Rat   670 -------GDNTRSLVGRGSS-----PRGSLSPRSPVSNLQIRYDQPSSSGLESLPPVAVSI--EQ 720

  Fly   616 L------ELQQALLQQ--------------QLQGQSIMIQDQAGNLVP----LQLDGTQ------ 650
            |      |.||.||:|              |||.::..:::|..||..    |||...|
  Rat   721 LLERQWSEGQQFLLEQGTPSDILGMLKSLHQLQVENRRLEEQIKNLTAKKERLQLLNAQLSVPFP 785

  Fly   651 AIYTTAPQAQRQQTTATYQTTQQQQQQPAQQPAGQAQQQPH----YELDN-------------VT 698
            || ||.|....|..|.|.||.......       .:.:.||    :..||             .:
  Rat   786 AI-TTNPSPSHQIHTYTAQTAPTTDSL-------NSSKSPHIGNSFVPDNSLPVLNQDLTSSGQS 842

  Fly   699 YLSSTAAATPTSAEQQQQQQ-------QQQH--VIGTVQSYQILTPDGLQNFQPKLETAE----- 749
            ..||:|.:||..|.|...||       ||.:  .:|.:.|       |:|.....:....
  Rat   843 TSSSSALSTPPPAGQSPAQQGSGVSGVQQVNGVTVGPLAS-------GMQTVTSTIPAVSAVGGI 900

  Fly   750 LGDLCPYSQYTFT-----------------------THAGAQP-----------TLNANALDAQT 780
            :|.| |.:|....                       ||....|           |.:|:.|...:
  Rat   901 IGAL-PGNQLAINGIVGALNGVIQTPVTISQNPAPLTHTSVPPNAAHPMPAAALTNSASGLGLLS 964

  Fly   781 QHQQHHQQQQHHHQQQQHHQQT----------QLLQQQPFATHHNPHQQFMELKNEL------LI 829
            ..|:....||...||..:.||.          ||:|||    ||.|..|.|:|....      |:
  Rat   965 DQQRQMFLQQQQFQQLLNSQQLTPEQHQAFLYQLMQQQ----HHPPELQQMQLPGPTQIPINNLL 1025

  Fly   830 KGGDAYTLDTAS 841
            .|..|..|.||:
  Rat  1026 AGPPAPPLHTAT 1037

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
seq	NP_001027415.1	C2H2 Zn finger	404..430	CDD:275370	4/26 (15%)
Mllt10	XP_038951869.1	PHD_AF10_AF17	24..71	CDD:277049
		ePHD_AF10	78..206	CDD:277178
		CC_AF10	717..780	CDD:411015	18/64 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900