DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment seq and jade1

DIOPT Version :9

Sequence 1:	NP_001027415.1	Gene:	seq / 3772396	FlyBaseID:	FBgn0028991	Length:	882	Species:	Drosophila melanogaster
Sequence 2:	NP_956099.1	Gene:	jade1 / 327437	ZFINID:	ZDB-GENE-030131-5648	Length:	829	Species:	Danio rerio

Alignment Length:	496	Identity:	96/496 - (19%)
Similarity:	172/496 - (34%)	Gaps:	159/496 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   261 ADIIKYD---PQH-GVVGDEEDDDENGMLHVKYEEQ---------------SLEHDPENEHDAE- 305
            ||.:|:.   |:| |:..:||:.|::..:.|...|.               .|..:||....:|
Zfish   349 ADEVKFKSFCPKHSGLDWNEEEGDDDRPVKVPTREDRSRNRGIDFSASSQTRLSQNPEETRLSER 413

  Fly   306 ----QEHEYEEYQVIKAEVEAEAAELAAGTT----SYTISQEQTGSGNTVLSSMVPKSGSAAAAK 362
                |:.|.|.|:.:.|:..||..:|.....    .|...:.:......::.....:..|.|..:
Zfish   414 KLRVQQLEDEFYRFVAADEVAEHLQLPLEMVDILFQYWKLKRKVNFNQPLIMPKKEEEDSLARRE 478

  Fly   363 QK-RKRKTRVIADDEQGEYLEKMSVRGLD--IARYEHIIDGVAYCLVCAKNDIFKTFKNKYSFQR 424
            |: ..|:.|:.....|.  ||:  ||.|.  ::|.|.|           |..:.:.  .:..|..
Zfish   479 QEVLLRRLRLFTHLRQD--LER--VRNLTYMVSRRERI-----------KRTLCRV--QEQIFHH 526

  Fly   425 HAYLFHEGQ------NRKIFAC--------PI----------C--NKEFSRPDK-MKMHKKDKHG 462
            |..|..:|:      .|::...        |:          |  |...|..:| ...::..||.
Zfish   527 HVRLLEQGRVTGVSSTRRLEEAMFYFRTTPPVPASPQPLKGHCGQNSTLSSSEKGSNSYRSSKHI 591

  Fly   463 DVPMPPSATTTPLKADGPPAK----RARTARTPRVR----KTKDGSTPTKKRLAQIDSVLDDVQN 519
            :...|     ..:..||.|:.    |:.|..:...|    :|:.|.:..|:.  :.:..|:| :.
Zfish   592 EADKP-----AKMLMDGVPSSGDSVRSETVMSASSRRSEGRTRSGESHRKEE--ESERPLED-RR 648

  Fly   520 GESLTMAPVSVSHSQQQQQQQIQHSIT---TLAPSTPSQPQHQLQTLPSLDFSGMILPGGAQLAL 581
            .:|.....||:       :.:::|:.:   ||:..|      :|.|:..            :|.|
Zfish   649 RKSKLWDQVSI-------KDKLRHAKSMEDTLSSET------ELDTMDD------------RLLL 688

  Fly   582 ANPGATSSVGLQRGPATPNGQPAPPTTTLIYSNQLELQQALLQQQLQGQSIMIQDQAGNLVPLQL 646
            ::..|.|..      ..||          :||.......|..|              |.|||
Zfish   689 SHTNANSVA------TAPN----------MYSGSPRKTNASHQ--------------GKLVP--- 720

  Fly   647 DGTQAIYT------TAPQAQRQQTTATYQTTQQQQQQPAQQ 681
            :||...:.      ..|: :.::|:|..||.:|:....|.|
Zfish   721 NGTSGRHLKNWGSFRIPK-RSERTSAGRQTERQEADNTADQ 760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
seq	NP_001027415.1	C2H2 Zn finger	404..430	CDD:275370	4/25 (16%)
jade1	NP_956099.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40
		EPL1	<104..173	CDD:287484
		PHD_JADE1	198..243	CDD:277149
		ePHD_JADE	251..361	CDD:277141	4/11 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	368..408		8/39 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	556..651		19/102 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	697..829		20/98 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900