DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment seq and Brpf3

DIOPT Version :9

Sequence 1:	NP_001027415.1	Gene:	seq / 3772396	FlyBaseID:	FBgn0028991	Length:	882	Species:	Drosophila melanogaster
Sequence 2:	XP_006256191.1	Gene:	Brpf3 / 309647	RGDID:	1306868	Length:	1328	Species:	Rattus norvegicus

Alignment Length:	794	Identity:	143/794 - (18%)
Similarity:	256/794 - (32%)	Gaps:	260/794 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 GIPQQQQQQQYASTDGNVYQLQNEILCDANGHAVTAATASYQTTASSPQQQQQQQQQQQNVATSV 121
            |:..:.:..:..|.:|.::.::....|:|  |:.:.|||  :....||:.           .:.|
  Rat   486 GLFMKIEPMRETSLNGTIFTVRKTAYCEA--HSPSVATA--RRKGDSPRS-----------LSEV 535

  Fly   122 ADNVVTTISSSSILHTNANTNGVDTLAATQQQQQQQQQQQQQQQQQHYHYITTTGEDGQTPTTIV 186
            .|.                    |.|.....:::|::.:::             |::||
  Rat   536 GDE--------------------DGLKEGGGEEEQEEGEEE-------------GQEGQ------ 561

  Fly   187 FENYNGGMPA----------VSSAAPTPVPVSQANAPATTTTTALVNTDGTIIEF---------D 232
                 ||:.:          ::|.......:.:|.....:.|..:|    |:.:.         .
  Rat   562 -----GGVGSPLKGVSKKSKMTSKQKIKKELEEAGRETPSITVPMV----TVPQIPSYRLNKICS 617

  Fly   233 GSTYE----------EYHVLKSEPGSSDCL-----SNGSSAVAADIIKYDPQHGVVGDEEDDDEN 282
            |.:::          .|.:||.:..:...|     |:..|...|:..::|.:...|.:|
  Rat   618 GLSFQRKNQFMQRLHNYWLLKRQARNGVPLIRRLHSHLQSQRNAEQREHDEKTSAVKEE------ 676

  Fly   283 GMLHVKYEEQSLEHDPENEH---DAEQEHEYEEYQVIKAEVEAEAAELAAGT----TSYTISQEQ 340
                :|| .|.|.||.|...   :..::.|..:.:.:|.:..|...||...|    |:..:.||:
  Rat   677 ----LKY-WQKLRHDLERARLLIELIRKREKLKREQVKVQQAAMELELMPFTVLLRTTLDLLQEK 736

  Fly   341 TGS---GNTVLSSMVPK-----SGSAAAAKQKRKRKTRVIADDEQGEYLEKMSVRGLDIARYEHI 397
            ..:   ...|..|.||.     |.....:..:||.::.:....|  |:.|..::...:..:|.
  Rat   737 DPAHIFAEPVSLSEVPDYLEFISKPMDFSTMRRKLESHLYHTLE--EFEEDFNLIVTNCMKYN-- 797

  Fly   398 IDGVAYCLVCAKNDIFKTFKNKY-----SFQRHAYLFHEGQNRKIFACPICNKEFSRPDKMKMHK 457
                      ||:.||.....:.     :..|||    ..|...|...|..........|::...
  Rat   798 ----------AKDTIFHRAAVRLRDLGGAILRHA----RRQAENIGYDPERGTHLPESPKLEDFY 848

  Fly   458 KDKHGDVP----------MPPSATTTPL--KADGPPAKRARTARTPRVRKTKDGSTPTKKRLA-- 508
            :....||.          :.|.|....|  |.|...|.|:..|||.|||..:......:::||
  Rat   849 RFSWEDVDNILIPENRAHLSPEAQLKELLEKLDLVSAMRSSGARTRRVRMLRREINALRQKLAQP 913

  Fly   509 ---QIDSVLDDVQNGESLTMAPVSVSHSQQQQQQQIQHSITTLAPSTPSQPQHQLQTLPSLDFSG 570
               |:.|:...|.|||....:....:..:|..|::.:        ....:...||...|:|:
  Rat   914 PPPQLLSLTKTVPNGELPAGSRGDAAGLEQTLQEEPE--------DEGDRDDSQLPAPPTLE--- 967

  Fly   571 MILPGGAQLALANPGATSSVGLQRGPATPNGQPAPPTTTLIY----SNQLELQQALLQQQLQGQS 631
                        ..|...|:..|..|      |.|||...|.    |.:|...:.:..::|.|.|
  Rat   968 ------------PTGPAPSLSEQESP------PDPPTLKPISDSKPSGRLPKPRKVDDEELLGDS 1014

  Fly   632 IMIQDQAGNLVPLQL----DGTQAIYTTAPQAQRQQTTATYQTTQQQQQQPAQQPAG-------- 684
            .:   |.|: .|||.    :|...:..|.|.:                  |...|.|
  Rat  1015 AL---QLGS-EPLQCLLSDNGADRLPLTNPDS------------------PPGTPLGNVGRRTSV 1057

  Fly   685 ---------QAQQQPHYELDNVTYLSSTAAATPTSAEQQ-----------------QQQQQQQHV 723
                     :.|:.|...|:|    ...|.|:|.|.|::                 ::..||:..
  Rat  1058 LFKKAKNGVKLQRGPDGTLEN----GEDAPASPASMEEEHCSRKRPRSQSCSDSEGERSPQQEEE 1118

  Fly   724 IGTVQSYQILTPDG 737
            .|....:...|..|
  Rat  1119 TGVTNGFGKHTESG 1132

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
seq	NP_001027415.1	C2H2 Zn finger	404..430	CDD:275370	7/30 (23%)
Brpf3	XP_006256191.1	EPL1	177..323	CDD:287484
		PHD_BRPF	341..394	CDD:277047
		ePHD_BRPF3	398..515	CDD:277173	5/30 (17%)
		Bromo_brd1_like	721..818	CDD:99944	19/110 (17%)
		DUF2890	909..>1004	CDD:287991	25/123 (20%)
		BR140_related	1197..1312	CDD:99900
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900