DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment seq and Mllt6

DIOPT Version :9

Sequence 1:	NP_001027415.1	Gene:	seq / 3772396	FlyBaseID:	FBgn0028991	Length:	882	Species:	Drosophila melanogaster
Sequence 2:	XP_006533395.1	Gene:	Mllt6 / 246198	MGIID:	1935145	Length:	1109	Species:	Mus musculus

Alignment Length:	930	Identity:	176/930 - (18%)
Similarity:	291/930 - (31%)	Gaps:	312/930 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 SQTSAATGGATAAAEASTSKSSQGQQQQIVYVNMLPAANTLNGIP--------QQQQQQQYASTD 71
            |.|||::  :::::.:|:|.||.|..|        ||.::|...|        :|.::.:|...
Mouse   337 SFTSASS--SSSSSSSSSSSSSGGPFQ--------PAGSSLQSSPDFAAFPKLEQPEEDKYPKP- 390

  Fly    72 GNVYQLQNEILCDANGHAVTAATASYQTTASSPQQQQQQQQQQQNVATSVAD--NVVTTISSSSI 134
                       .|....|..:.||        |:..:....:|:.|.:....  ...||.||||.
Mouse   391 -----------ADPTPPAPPSPTA--------PEPPKADLFEQKVVFSGFGPIMRFTTTASSSSR 436

  Fly   135 L-------HTNANTNGVDTLAATQQQQQQQQQQQQQQQQQHYHYITTTGEDGQTPTTIVFE---- 188
            .       :.:.:..|....|.|.::.....              .|.|...:.|.|.:.|
Mouse   437 ARAPSPGDYKSPHITGAGASAGTHKRMPALS--------------ATLGPAEEAPETTLKEKKHK 487

  Fly   189 -----NYNGGMPAVS-----SAAPTPVPVSQANAPAT-----TTTTALVNTDGTIIE--FDGSTY 236
                 .:..|.|..|     ::.||      |:.||.     |.|.|...:.|:::.  ..|...
Mouse   488 ASKRSRHGPGRPKGSRGKEGASGPT------ASLPAAQLAGFTATAASPFSGGSLVSAGLGGLAS 546

  Fly   237 EEYHVLKSEPGSSDCLSNGSSAVAADII--KYDP-QHGVVGDEEDDDENGMLHVKYEEQSLEHDP 298
            ..:    ...||...||..||.:.|.|.  ..|| .||          .|||.
Mouse   547 RTF----GPSGSLPSLSLESSLLGAGIYTSNKDPISHG----------GGMLR------------ 585

  Fly   299 ENEHDAEQEHEYEEYQVIKAEVEAEAAELAAGTTSYTISQEQTGSGNTVLSSMVPKSGSAAAAKQ 363
                                           ...|..:|           ||::..:|::|..:.
Mouse   586 -------------------------------AVCSTPLS-----------SSLLGPTGTSALPRL 608

  Fly   364 KRKRKTRVIADDEQGEYLEKMSVRGLDIARYEHIIDGVAYCLVCAKNDIFKTFKNKYSFQRHAYL 428
            .|...|..:|.....                            .:...:|....:.:|.
Mouse   609 SRSPFTSTLASSSAS----------------------------ISTTQVFSLAGSTFSL------ 639

  Fly   429 FHEGQNRKIFACPI---------CNKEFSRPDKMKMHKKDKHGDVPMPPSATTTPLKADGPPAKR 484
                .:..||..|:         .....:.|| ::......||..|....::.:|:.:  .||..
Mouse   640 ----PSSHIFGTPMGTVNPLLTQAESSHTEPD-LEDCSFRCHGTSPQESLSSMSPISS--LPALF 697

  Fly   485 ARTARTPRVRKTKDGSTPTKKRLAQIDSVLDDVQNGESLTMAPVSVSHSQQQQQQQIQHSITTLA 549
            .:|: .|......|.:.|....:.|:.....|.:.|.:: :..:...|:.|::.|::|..|.:|
Mouse   698 DQTS-APCAGGQLDSTAPGTTNMEQLLEKQGDGEAGVNI-VEMLKALHALQKENQRLQEQILSL- 759

  Fly   550 PSTPSQPQHQLQTLPSLDFSGMILPGGAQLALANPGATSSVGLQRGPATPNGQPAPPTTTLIYSN 614
                :..:.:||.|            ..||::..|...:::     |||....|.|
Mouse   760 ----TAKKERLQVL------------NVQLSVPFPALPAAL-----PATNGPIPGP--------- 794

  Fly   615 QLELQQALLQQQLQGQSIMIQDQAGNLVPLQLDGTQAIYTTAPQA---QRQQTTATYQTTQQQ-- 674
                 ..||.|.....|:.:.........|.||.:.:..:..|.:   .|..::.::.:|...
Mouse   795 -----YGLLPQAGSSDSLSVSKSPPGKNSLGLDNSLSTSSEDPHSGCPSRSSSSLSFHSTPPPLP 854

  Fly   675 --QQQPAQQPAGQAQQQPHYELDNVTYLSSTAAATPTSAEQQQ------------QQQQQQHVIG 725
              ||.||..|                 |:...|..|...:.|.            .....:.::|
Mouse   855 LLQQSPATLP-----------------LALPGAPAPLPPQPQNGLGRAPGATGLGAMPMAEGLLG 902

  Fly   726 TVQSYQILTPDGLQNFQPKLETAELGDLCPYSQYTFTTHAGAQPTLN-ANALDAQTQHQQHHQQQ 789
            .:.....|..:||..   .|..|...:....||      ||..|||. ...|::.|:.|:|..||
Mouse   903 GLAGSGSLPLNGLLG---GLNGAAAPNPAGLSQ------AGGAPTLQLPGCLNSLTEQQRHLLQQ 958

  Fly   790 QHHHQQQQHHQQTQLLQQQPFATHHNP--HQ--QFMELKNE---LLIKGGDAYTLDTASMYHLPF 847
                |:||..|..|||........|..  :|  |.|:.|.|   |.:.||.  .|..||:  |..
Mouse   959 ----QEQQLQQLQQLLASPQLTPEHQTVVYQMIQQMQQKRELQRLQMAGGS--QLPMASL--LAG 1015

  Fly   848 SPTSMINAVNDVNTSSLLET 867
            |.|.:::|    .|..||.|
Mouse  1016 SSTPLLSA----GTPGLLPT 1031

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
seq	NP_001027415.1	C2H2 Zn finger	404..430	CDD:275370	2/25 (8%)
Mllt6	XP_006533395.1	PHD_AF10_AF17	7..54	CDD:277049
		ePHD_AF17	61..185	CDD:277179
		SR-25	229..>329	CDD:371095
		HALZ	<737..763	CDD:390154	6/30 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900