DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment seq and JADE2

DIOPT Version :9

Sequence 1:	NP_001027415.1	Gene:	seq / 3772396	FlyBaseID:	FBgn0028991	Length:	882	Species:	Drosophila melanogaster
Sequence 2:	NP_001276914.1	Gene:	JADE2 / 23338	HGNCID:	22984	Length:	850	Species:	Homo sapiens

Alignment Length:	370	Identity:	70/370 - (18%)
Similarity:	122/370 - (32%)	Gaps:	106/370 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   278 DDDENGMLHVKYEEQSLEHD---PENEHDAE---------------------QEHEYEEYQVIKA 318
            |:||     ||::....||.   |.||..:|                     |:.|.:.|::::.
Human   367 DNDE-----VKFKSFCQEHSDGGPRNEPTSEPTEPSQAGEDLEKVTLRKQRLQQLEEDFYELVEP 426

  Fly   319 EVEAEAAELAAGTTSYTISQ---EQTGSGNTVLSSMVPKSGSAAAAKQKRK----RKTRVIADDE 376
            ...||..:||.....:....   ::..:.|..|  :.||:.......|:.:    |:.::.....
Human   427 AEVAERLDLAEALVDFIYQYWKLKRKANANQPL--LTPKTDEVDNLAQQEQDVLYRRLKLFTHLR 489

  Fly   377 QGEYLEKMSVRGLDIARYEHIIDGVAYCLVCAKNDIFKTFKNKYSF-QRHAYLFHEGQNRKIFAC 440
            |            |:.|..::      |.:..:.:     :.|::. :....:||  ...|:...
Human   490 Q------------DLERVRNL------CYMVTRRE-----RTKHAICKLQEQIFH--LQMKLIEQ 529

  Fly   441 PICNKEFSRPDKMKMHKKDKHGDVPMPPSATTTPLKADGPPAKRARTARTPRVRKTKDGSTPTKK 505
            .:|.:...|..|.|.....:.|              .:|                 ..|||..|:
Human   530 DLCRERSGRRAKGKKSDSKRKG--------------CEG-----------------SKGSTEKKE 563

  Fly   506 RL-AQIDSVLDDVQNGESLTMAPVSVSHSQQQQQQQIQHSITTLAPST-PSQPQHQLQTLPSLDF 568
            :: |..||||..:. |.| |..|:..:.......|.:|.:...:|.|. |....|:....|.|..
Human   564 KVKAGPDSVLGQLA-GLS-TSFPIDGTFFNSWLAQSVQITAENMAMSEWPLNNGHREDPAPGLLS 626

  Fly   569 SGMILPGGAQLAL-----ANPG--ATSSVGLQRGPATPNGQPAPP 606
            ..::......|:.     ..||  |..:.|..|.||.....|.||
Human   627 EELLQDEETLLSFMRDPSLRPGDPARKARGRTRLPAKKKPPPPPP 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
seq	NP_001027415.1	C2H2 Zn finger	404..430	CDD:275370	2/26 (8%)
JADE2	NP_001276914.1	EPL1	<153..191	CDD:287484
		PHD_JADE2	217..262	CDD:277150
		ePHD_JADE2	270..380	CDD:277175	5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900