DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment seq and Brd1

DIOPT Version :9

Sequence 1:	NP_001027415.1	Gene:	seq / 3772396	FlyBaseID:	FBgn0028991	Length:	882	Species:	Drosophila melanogaster
Sequence 2:	NP_001028446.2	Gene:	Brd1 / 223770	MGIID:	1924161	Length:	1189	Species:	Mus musculus

Alignment Length:	590	Identity:	120/590 - (20%)
Similarity:	205/590 - (34%)	Gaps:	176/590 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   193 GMPAVSSAAPTP----VPVSQANAP---------ATTTTTALVNTDGTIIEFDGSTYEEYHVLK- 243
            |.||.:||.|.|    |..|..:||         ...:...|.|.    :|:| ...|:|..|:
Mouse   109 GTPASASALPEPKVRIVEYSPPSAPRRPPVYYKFIEKSAEELDNE----VEYD-MDEEDYAWLEI 168

  Fly   244 -SEPGSSDCLSNGSSAVAADIIKYDPQHGVVGDEEDDDENGMLHVKYEEQSLEHDPENEHDAEQE 307
             :|....||:    |||:.::.::                  |..::|::|.   .||:...||:
Mouse   169 INEKRKGDCV----SAVSQNMFEF------------------LMDRFEKESY---CENQKQGEQQ 208

  Fly   308 HEYEEYQVIKAEVEAEA-----------AELAAGTTSYTIS-------------QEQTGSGNTVL 348
            ...:|..|....::.|.           ..||.....|.:.             |.:....:.||
Mouse   209 SLIDEDAVCCICMDGECQNSNVILFCDMCNLAVHQECYGVPYIPEGQWLCRHCLQSRARPADCVL 273

  Fly   349 SSMVPKSGSAAAAKQKRKRKTRVIADDEQGE----------------YLEKM-SVRGLDIARYEH 396
               .|..|.|.       :||   .||..|.                ::|.: .||.:..||::.
Mouse   274 ---CPNKGGAF-------KKT---DDDRWGHVVCALWIPEVGFANTVFIEPIDGVRNIPPARWKL 325

  Fly   397 II-----DGVAYCLVCAKNDIFKTFKNKYSFQRHAYLFHEGQNRKIFACPICNKEFSRPDKMKMH 456
            ..     .||..|:.|.|.:.:..|....:.:...|:..|         |:  ||.:........
Mouse   326 TCYLCKQKGVGACIQCHKANCYTAFHVTCAQKAGLYMKME---------PV--KELTGGSATFSV 379

  Fly   457 KKDKHGDVPMPPSATTTPLKADGPPAKR---------ARTAR-TPRVRKTKDGSTPTKKRLAQID 511
            :|..:.||..||..|..||...|....:         .:|.| |.:|||.   :...||.||:..
Mouse   380 RKTAYCDVHTPPGCTRRPLNIYGDVEMKNGVCRKESSVKTVRSTSKVRKK---AKKAKKTLAEPC 441

  Fly   512 SVLDDVQNGESLTMAPVSVSHSQQQQQQQIQHSITTLAPSTPSQPQHQLQTLPSLDFSGMILPGG 576
            :||..|       .||    :...|:..:|.:.:.........:..|....|..|..:|..|...
Mouse   442 AVLPTV-------CAP----YIPPQRLNRIANQVAIQRKKQFVERAHSYWLLKRLSRNGAPLLRR 495

  Fly   577 AQLALANPGATSSVGLQRGPATPNGQPAPPTTTLIYSNQL--ELQQALL-------QQQLQGQSI 632
            .|.:|.:...|.    ||   ..:.:.......|.|..:|  :|::|.|       :::|:.:.:
Mouse   496 LQSSLQSQRNTQ----QR---ENDEEMKAAKEKLKYWQRLRHDLERARLLIELLRKREKLKREQV 553

  Fly   633 MIQDQAGNLVPLQLDGTQAIYTTAPQAQRQQTTATYQTTQQQQQQPAQ---QPAGQAQQQPHYEL 694
            .::..|   :.|:|.....:..:..:             |.|::.||:   ||. ..::.|.| |
Mouse   554 KVEQMA---MELRLTPLTVLLRSVLE-------------QLQEKDPAKIFAQPV-SLKEVPDY-L 600

  Fly   695 DNVTY 699
            |::.:
Mouse   601 DHIKH 605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
seq	NP_001027415.1	C2H2 Zn finger	404..430	CDD:275370	5/25 (20%)
Brd1	NP_001028446.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		Interaction with KAT7/HBO1 and histones. /evidence=ECO:0000250\|UniProtKB:O95696	31..80
		EPL1	47..196	CDD:287484	26/113 (23%)
		PHD_BRPF2	214..267	CDD:277147	6/52 (12%)
		ePHD_BRPF2	271..388	CDD:277172	28/140 (20%)
		Bromo_brd1_like	566..663	CDD:99944	10/55 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	754..776
		BR140_related	1058..1173	CDD:99900
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900