DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment seq and Kdm4b

DIOPT Version :9

Sequence 1:	NP_001027415.1	Gene:	seq / 3772396	FlyBaseID:	FBgn0028991	Length:	882	Species:	Drosophila melanogaster
Sequence 2:	XP_030105461.1	Gene:	Kdm4b / 193796	MGIID:	2442355	Length:	1124	Species:	Mus musculus

Alignment Length:	367	Identity:	70/367 - (19%)
Similarity:	131/367 - (35%)	Gaps:	102/367 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   474 PLKADGPPAKRARTARTPRVRKTKDGSTPTKKRLAQIDSVLDDVQ---NGESL-------TMAPV 528
            |.:..||.:.|.|:  .|:..|.::..:|.:.....  |.||:.:   .||::       .:.|
Mouse   393 PTRRPGPASHRRRS--QPKKSKPEESRSPGEATAGV--STLDEARGCSRGEAMPEDEEEEELLP- 452

  Fly   529 SVSHSQQQQQQ---------QIQHSITTLAPSTPSQPQHQLQTLPSLDFSGMILPGGAQLALANP 584
            |..|..:..::         :.::...|.:||:|          |.|.....:.|  .:..|..|
Mouse   453 SQGHEAEGVEEDGRGKPRPTKARNKKKTPSPSSP----------PLLSAPPALFP--TEEVLRPP 505

  Fly   585 GATSSVGLQRGPATPNGQPAPPTTTLIYSNQLELQQALLQQQ--------LQGQSIMIQDQA--- 638
            ....|.|...||....|.| |||...:......:::|.::.:        |...|....|:.
Mouse   506 PQPKSPGPAMGPMAAEGGP-PPTPLNVVPPGAPVEEAEVRPRPIIPMLYVLPRTSSTDGDREHSA 569

  Fly   639 -GNLVPLQL---DGTQAIYTTAPQAQRQQTTATYQTTQQQQQQPAQQPAGQAQQQPHYELDNVTY 699
             ..|.|::|   :..||      ||...|.|..:...:.:.::..:.|.|:...:
Mouse   570 HAQLAPMELGPEEENQA------QAGDSQGTTPFSKLKVEIKKSRRHPLGRPPTR---------- 618

  Fly   700 LSSTAAATPTSAEQQQQQQQQQHVIGTVQSYQILTPDGLQ------------NFQPKLE---TAE 749
                   :|.|..:|:....::..:.:.:. .:..|:.|:            :||.:.:   .|.
Mouse   619 -------SPLSVVKQEASSDEEAFLFSGED-DVTDPEALRSLLSLQWKNKAASFQAERKFNAAAA 675

  Fly   750 LGD----LC----PYSQYTFTTHAGAQPTLNANALDAQTQHQ 783
            |.:    :|    ||||.:..:   ..|||.|..:...||.|
Mouse   676 LSEPYCAICTLFYPYSQVSCLS---GLPTLMAPTVTCPTQPQ 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
seq	NP_001027415.1	C2H2 Zn finger	404..430	CDD:275370
Kdm4b	XP_030105461.1	JmjN	15..56	CDD:128818
		JmjC	176..292	CDD:334913
		PHD_SF	680..814	CDD:389947	12/38 (32%)
		PHD_SF	823..932	CDD:389947
		Tudor_2	948..982	CDD:375553
		Tudor_2	1006..1040	CDD:375553
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900