DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment seq and brd1b

DIOPT Version :9

Sequence 1:	NP_001027415.1	Gene:	seq / 3772396	FlyBaseID:	FBgn0028991	Length:	882	Species:	Drosophila melanogaster
Sequence 2:	XP_005163199.1	Gene:	brd1b / 100009661	ZFINID:	ZDB-GENE-070209-98	Length:	1168	Species:	Danio rerio

Alignment Length:	466	Identity:	84/466 - (18%)
Similarity:	164/466 - (35%)	Gaps:	113/466 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 SILHTNANTNGVDTLAATQQQQQQQQQQQQQQQQQHYHYITTTGEDGQTPTTIVFENYNGGMPAV 197
            :|...:.:.|||...||.:::.:..|:::.::.:..             |.|:|        |.|
Zfish   397 TIYDDSKSKNGVCQKAAHRERVKGCQKKKNKKPESE-------------PDTVV--------PTV 440

  Fly   198 SSAAPTPVPVSQANAPATTTTTALVNTDGTIIEFDGSTYEEYHVLKSEPGSSDCLSNGSSAV--- 259
            |..:.||...:      |......|......:|    ....|.:||.:.      .||...:
Zfish   441 SGPSITPKSFN------TILNQVSVQKKRMFVE----RVLSYWMLKRQS------RNGVPLIRRL 489

  Fly   260 -AADIIKYDPQHGVVGDEED---DDENGMLHVKYEEQSLEHDPENEH---DAEQEHEYEEYQVIK 317
             .|...:.||       |:|   ||...:.....:...|.||.|...   :..::.|    ::.:
Zfish   490 QTAIQTQKDP-------EDDPCVDDHQTLTDQLKDLHRLRHDLERARLLLELIRKRE----KLKR 543

  Fly   318 AEVEAEAAELAAGTTSYTISQEQTGSGNTVLSSMVPKSGSAAAAKQKRKRKTRVIAD----DEQG 378
            .|::.:.:.|....|.:.|          :|        ..|..:.:.|.:.::.|.    .|..
Zfish   544 EEMKLQQSVLEMQLTPFPI----------IL--------RVALDQLQEKDQAKIFAQPVSVTEVP 590

  Fly   379 EYLEKMSVRGLDIARYEHIIDGVAYCLVCAKNDIFKTFKN---KYSFQRHAYLFHEGQNRKIFAC 440
            :||:.:. ..:|.:.....|||..|..:....:.|....|   ||: .:..|.:..|...:....
Zfish   591 DYLDHIK-HPMDFSTMRKRIDGHEYQSLDEFEEDFNLIINNCLKYN-AKDTYFYRAGVRMRDHGG 653

  Fly   441 PICNKE--------FSRPDKMKMHKKDKHGDVPMPPSATTTPLKADGPPAKRARTARTPRVRKTK 497
            .|..:.        |..|..:.:.:..|   :.:|||.|...:.....||.||..::..:::|..
Zfish   654 VILRRTRRETERIGFEFPSGIHLPEPPK---LELPPSFTWHDVDRVLNPANRAHMSKDEQLKKLL 715

  Fly   498 D--------GSTPTK-KRLAQIDSVLDDVQNGESLTMAPVSVSHSQQQQQQQIQHSITTLAPSTP 553
            :        .|.|:: |||..:...:.||:........|.|:..:..:::::        ||...
Zfish   716 EMLDLTFAMKSCPSRSKRLKLLKKTIGDVRMDMGQKTEPPSLEQNNTKEEEK--------APLIL 772

  Fly   554 SQPQHQLQTLP 564
            .|.:...::||
Zfish   773 PQEEEGDKSLP 783

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
seq	NP_001027415.1	C2H2 Zn finger	404..430	CDD:275370	5/28 (18%)
brd1b	XP_005163199.1	EPL1	45..193	CDD:287484
		PHD_BRPF2	211..264	CDD:277147
		PHD_SF	268..386	CDD:304600
		Bromo_brd1_like	559..656	CDD:99944	19/116 (16%)
		PWWP	1042..1157	CDD:295359
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5141
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900