Protein Alignment Plp and Pcnt

DIOPT Version :9

• Sequence 1: NP_001027574.2
• Gene: Plp / 3772382
• FlyBaseID: FBgn0086690
• Length: 2895
• Species: Drosophila melanogaster
• Sequence 2: XP_038955131.1
• Gene: Pcnt / 309692
• RGDID: 1595865
• Length: 2951
• Species: Rattus norvegicus
• Alignment Length: 3147
• Identity: 664/3147 - (21%)
• Similarity: 1122/3147 - (35%)
• Gaps: 1004/3147 - (31%)

  Fly   364 KTDGSAAISASAPQETQVDESQITDEQDHSMEEIVATNESIEVT---YEAEETVNTSQKQDL--- 422
            |..|| |:.||..:|..|........|..::.|..:...::|.|   :.|:|      :||.
  Rat    40 KRKGS-AVHASVQEEGSVAPPNSELPQGAAVSERESCGNTLEGTGGAFAAQE------QQDCELG 97

  Fly   423 ITDLDEESEDQVHVDNRPTSTLQALKLPALQ---------QPQI----VERKAATALTTLRLQAD 474
            :|||  :.:.|.....:|..|..:|:|.||:         |.::    ::::..||||.||...:
  Rat    98 VTDL--QGQQQPQQQPQPPQTAHSLELEALRLSLNNMHTAQLELTQANLQKEKETALTELREMLN 160

  Fly   475 VLEPLELTILEMDDDENEEDDDDEESSLQLMKLRLMAMNQQMIVDNAPKLSPTEAEQTQVTSSSN 539
            .....||.:|:          ..::..|:||:                :....|.|:..:.:...
  Rat   161 GRRAQELALLQ----------SRQQCELELMR----------------EQHAREKEEMALRNEQE 199

  Fly   540 NLEIKQMERVPLTEFSKDV--LEDITE--ESERLLSMST-----------TMEEEQDPPSLSLDE 589
            ..|:|:..|   :|..|.|  :|.:.:  ||||.|.:.|           .||..|:.....|.|
  Rat   200 TAELKEKFR---SEMEKTVQMMETLKQDWESERELCLETLRKELSAKHQSEMEGLQNQFQKELSE 261

  Fly   590 SKTLLQ---PGAHKTGGSSSSLVSL-NMLKQLEAKVQELHTQLETKDNCLASLNLQLETARRESS 650
            .|..|:   ...|:      :.||| |:..|.:|.:::|...|.: ::|....:|:|....:|.:
  Rat   262 QKAELEKIFQAKHE------AEVSLKNLEAQHQAAIRKLQEDLRS-EHCQYLQDLELRFREKEKA 319

  Fly   651 AG------PASARDSSS--------LMTNSTEYRTLQEELGGPTLDIYVEMSRRDELIAKLTDSL 701
            ..      .||..|..:        |.:.....:|.:||..|....:..:.|..:||....:|..
  Rat   320 KELELETLQASYEDLKAQSQEEIRHLWSQLESMKTNREEQNGSWEPLLAQASHLEELQHLRSDFA 384

  Fly   702 QQSLNVRDKLQVDADRLGGEVQNLRRQLQETLDAVKRSSAVWPDQECNPGQRISEISMDLISESD 766
            ||....|.:.:       .|:::||...::.|:..:::   :.:......||:.|...:.:..::
  Rat   385 QQQQQERAQHE-------SELEHLRVYFEKKLNDAEKT---YQEDLTVFQQRLQEAREESLESAE 439

  Fly   767 DDLDRHFLTDNEERGSRSSKERQLTQLQTNEELGLQASNPEWTPTFSKQIEQFHTYLLPTEQRI- 830
            ......|   .||...|..||       ..:.|.||...|:   .....||.:...|...|::|
  Rat   440 ISSSCMF---PEETSGRERKE-------PPDPLDLQLEQPK---AQGSLIEDYQEKLSNAEEKIE 491

  Fly   831 --FQMVQRKFDDYLNQQITLCRDLGAQELKIA------RDQWESEKLT-------------SEQN 874
              .|..|:|..::...:..|.||  |:| |:|      |::.|||||:             ..|:
  Rat   492 LMKQEFQKKEAEWELSREDLKRD--AEE-KLASMFLELREKAESEKLSIINRFELRESSMRHLQD 553

  Fly   875 QQAAHAKQMEDLRKYFEHKCADLEKQFSDDVFSHKSQHQTGDSSSECSEVDQLPEEGAAAVSSKE 939
            ||||   |:.||.:....:...|.:         ..|..|.|....||:            ..||
  Rat   554 QQAA---QISDLERSLREQQGHLRQ---------LEQELTRDEVLLCSQ------------CGKE 594

  Fly   940 PSPRKRKRAELLLSPSHRQMTPCGLDSL----------GENTGKTEKDNTADIADLKIFYQTHIK 994
            ||..:.:::.:||    |:...|.|..|          .|...|..|:..|.:.|.:..:...::
  Rat   595 PSVAQDEKSAILL----REKEDCALQLLTAQNRFLEERKEIMEKFAKEQDAFLLDTQEKHSHELQ 655

  Fly   995 ELKRAHEDQVRKLSDRIKFYERQQGD-DDYKPATESPERTCPDQESA----------GGVANTSL 1048
            .|::.|:.|:  |:.|::...:...: .:...:.||.::...:...|          ..:....|
  Rat   656 LLQQGHQQQL--LALRMELETKHHSELTEQLASLESKQQALLETHVAKMQVKHDAEISALEKRHL 718

  Fly  1049 IIIDEDELNFNNESQVIQRIIEEYEKRLQEQLALARQDIATELEQQIKSLLSENTVDDQHWPKEL 1113
            ..:||.|..:..:   ||.|.:|::|.|:    |.|    .|||:|::.      .|..|
  Rat   719 SNLDELESCYVAD---IQTIRDEHKKALE----LLR----AELEEQLQK------KDSCH----- 761

  Fly  1114 ILLREKFTAKSQLEITQLNIKHAEEM----SRLKLEFEKQLNRKNKRHLTFDAARDLEQVICERD 1174
               ||..|.    |:.:|.:|||||:    :.|:::...|.....|     ..|.||:....::.
  Rat   762 ---REILTQ----ELEKLKLKHAEELQSVRNSLRVKMSAQHTESGK-----GPAADLQGAHQQKA 814

  Fly  1175 GLRELSKSFRSVLCRLAKCVAHCEEDLNATL-SEEVQRLLFHSR--------------------- 1217
            ....|......:           |||.:|.| ..:.:.|..|:.
  Rat   815 PAMALHNEGHQL-----------EEDGDAALGGADTEDLQHHAEPREREGPHTVEMQTSQTELAK 868

  Fly  1218 ------SQDGG---DDLEATISSSLNNTKHMLRVPDVHSLLEVVEDPSLVQFIDSKSNEEPSEDF 1273
                  |||.|   .|....:|..|...:..|.........|..|..:|:..:.:..:...||..
  Rat   869 PQELQASQDQGAQVRDQVFLLSRELEECRGELEQLQQRRERENQEGATLICMLRADVDLAQSEGK 933

  Fly  1274 DLNDCLER--------LKSEASYLLHLSED----LHKQRTHDESSEHL----------DE----- 1311
            .|.|.|.|        ||:..:....:||.    |..:...|.|...|          ||
  Rat   934 ALRDALRRLLDLFGETLKAAVTLKSRISERAGLLLDHEDAVDTSGAQLAAAALGEMWPDEGLLDI 998

  Fly  1312 ----PEKQEHELCCEAEDGLKTTGAVNQQVLSKFLRTNSLNDQQMGVANQRKNSNPEAGKTHSSL 1372
                ||..|....||          ::..|...|.         |...|.::...| ..|.:.||
  Rat   999 DRTLPEGAETSSVCE----------ISSHVCESFF---------MSPENTQECEQP-IRKVYQSL 1043

  Fly  1373 PPDLQEHAGNASELSFQLVQLK--NRLIKSEADRQNLQQQLSRTIDRNAELGQELQ---ALRDQL 1432
            ...::.....|.:.|.||...:  :|.::.|.  ::..:::::.:.:..||.:.|:   |.:|:|
  Rat  1044 STAVEGLLDMALDSSKQLEDARQLHRCVEKEF--RHRDEEMAQAVQKQQELLERLREESAAKDRL 1106

  Fly  1433 S-QLNS---------LNHTDYNEGYG---------LGTMKSLQEQGLDQSSASFLALQE------ 1472
            : :|::         :...|..|..|         :..::.|::| |.|:|...|.|:|
  Rat  1107 ALELHTAEGLLEGFKVEKADLQEALGKKEESEQQLIVELEDLRKQ-LQQASRELLTLKEENSVLW 1170

  Fly  1473 --------RARHLLSSSPVKEQPSRDHGNSTVILLQMIEDFCREGDKVVEFSKKDR--------- 1520
                    .|:...:.:||..      |.....|.:.:|...|:..:..:.|:|||
  Rat  1171 NQKETFTNEAKEREAGTPVSA------GREDAALQKEVESLTRDQWESRKQSEKDRATLLSQMRV 1229

  Fly  1521 -----ED-----------------LQSQIDTADKQLKDTRRFLEDQAAEREQERDEFQREIERLK 1563
                 ||                 |:.|:.|.||.|:..|:|:::||||||.||:|||:||:.|:
  Rat  1230 LESELEDQLVQHRGCAQLAEEVTTLKQQLATLDKHLRSQRQFMDEQAAEREHEREEFQQEIKWLE 1294

  Fly  1564 AQLRDKEK------EHSSYANASEEYAQLESQFRE--------------VNQQLC---------- 1598
            .|||...:      ..|..|...||...|:.:.||              .:|||.
  Rat  1295 GQLRQATRPRPPGPRDSQCAKLDEEVELLQEKLREKLDGFNELVIKKDLADQQLLIQEEEIKHLE 1359

  Fly  1599 ESNAKRDKFEVELKASIDK-------IFVLREIISELETQVQTKAL------NEEVL----AEKA 1646
            |:|....:...:|:..::|       :.|:....||:|   :.||:      |:|.|    ||:.
  Rat  1360 ETNENIQRQMAQLQEELEKQRRSTEELEVVNSRNSEIE---ELKAIIEHLQENQEQLQKAKAEEI 1421

  Fly  1647 QQLEEYVSLQMRDNDILQQEVH--------SLKTDIG---------------------------- 1675
            :||.|.:.....:..::...||        ||.|::.
  Rat  1422 EQLHEVIEKLQSELSLMGPTVHEMSDLPPGSLHTELSCLQAEGMGGQALHNELQAAQAAKGAFGQ 1486

  Fly  1676 ----EGYQSRIRVLEEKLKQSGPTA-------EQGVVLSQ-----VAEKLRDIETTLDQKTKALE 1724
                .|:...:..|:|:|:.:...|       |..|.|.|     :|.::::.|.||    ||.|
  Rat  1487 LLADHGHSQALEALQERLQDAEAAAARHLTELEHCVALRQAEVEAMASRIQEFEATL----KAKE 1547

  Fly  1725 SL----------HNSNATSNSASLSVTEDVSI------HGSKEPTAVGSPSHPSLTVEGVQ--RV 1771
            ::          .|....|:|..|   |.:.:      |..::.|:......|.|....||  |:
  Rat  1548 AIIVQRDLEIDAVNKWKVSHSVEL---EALLLALAHFQHAVEQQTSATPDEPPKLQQLLVQCARL 1609

  Fly  1772 TEKLD----RHTRVEEAAIKRIRDLEMQVHQMR---AGC----VELQHERDTLQGRMEEQ--TQR 1823
            :.:|.    |..|.:         :|:..||.|   .||    .|.|.:||   |.:|:.  :..
  Rat  1610 SHQLHVLYRRFLRCQ---------VELGQHQPRVASVGCADPPAEAQGKRD---GELEQDGVSSG 1662

  Fly  1824 ISTLQNRL--EEQRQRAEQLHRTGTSDLNTRVHELQGEVQNLYEQLAARDKQMANMRQQ------ 1880
            ::...:.|  :.:.::.|..| .|.:.|..::.:|:.::......:|.||..|...:.|
  Rat  1663 LALAPHSLVAQAKEEQPEDCH-LGNTSLRAQLRQLEEKLDPQAHSVAFRDTSMETCKLQQPNPLE 1726

  Fly  1881 ------LQRSKEEITRLETEVEVRT------------------QPDRSLVNKL---------QAE 1912
                  ....:|.......:|..:|                  .||.....||         ||.
  Rat  1727 NGSSNHCHNGEESRPSPPNDVPAKTTWDVIGVIKNQDLLAQIEMPDSPTPEKLASQGGAFSSQAS 1791

  Fly  1913 VQQKGAEIV-----KLKDKIRT---------EMINR-------------------------LAIP 1938
            |.  ||.::     ..||.:|.         |::.:                         ::.|
  Rat  1792 VH--GASLLPEEAEPQKDPVRALDLSSWSSPEVLRKEPSLEPQHSLPLTPGVGTVSLHSVDISSP 1854

  Fly  1939 DLMETML-AD----------------------KNDEIDHLRDQLEAKEKELQ----ASQQEASQI 1976
            |..:.:| ||                      .:.|..|:  :..|.||:::    .|......:
  Rat  1855 DWTDPLLQADVSGLLCYPGKSATGQAPLWVVAPSAEKHHV--ERTATEKDVEDFIVTSFDSQESL 1917

  Fly  1977 SSPSGAAGKQEGSGGKLSARTLSDIGSITEFPEPDVERRAAMRSLTALQMSEGAGGFLHQTMETS 2041
            :|||....::....||      ||        .||:   |||.:|.    |||           |
  Rat  1918 TSPSHELARRSDGSGK------SD--------GPDI---AAMLTLG----SEG-----------S 1950

  Fly  2042 KEAVANLTHKRTDDLSGFIVPYP-----------------VNTFEHPHYFQALGVTAQSTDGLTP 2089
            :....:|....|...|...|..|                 ...|:..|...||..:..|:..|:.
  Rat  1951 ETPTTDLVAATTGPFSRRFVQSPGAMREKEVHAKQMKALLQMVFDESHQILALSESQDSSSALSK 2015

  Fly  2090 GL-------VPRQIN-FSNLTEDSKLK---------TTSLLMHTPEL-----------PRPTTPP 2126
            |.       |||... .|..|.|...|         :..||....|:           |||.:..
  Rat  2016 GEPRDPLDGVPRDRQALSEGTSDRGEKEALGTHLTWSEELLQAIQEVFAREQENAELQPRPYSSD 2080

  Fly  2127 --EIHQLRVKL-------SDLQTEKQR----QQSELEKKLQDLQKELE----QEKEKLSRQAQTL 2174
              :.:.|..||       .|||..::.    .:|.|..::|.|:.:|.    |.:|||.:....|
  Rat  2081 LGDYNSLVKKLEKVIQEQGDLQKVREHACLPDRSSLLAEIQALRAQLRMTHLQNQEKLQQLCAAL 2145

  Fly  2175 QSYEE--SEAKYRLR---------------IENLESKVLETAAQAASDRENLRKELNCVSAAHEQ 2222
            .|.|.  |:.:::||               |.|...|.|....:||||   :||.|.....|.:.
  Rat  2146 TSTEARGSQREHQLRRQVELLAYKVEQEKCIANDLQKTLSKEQEAASD---VRKRLMVEQGAVQD 2207

  Fly  2223 CENAAAARKRE-------LEKLNSEV-------------------------KVKADQLHAALRRC 2255
            .::...|.|:|       |:|:..||                         ..|.::|...|.
  Rat  2208 LKSELHACKQENTNLLESLDKVQQEVLRLRYGHVTWSYSGTSSASAGRAVLDGKENELKVVLE-- 2270

  Fly  2256 ADLE--------LQVLTLERDLERLKNSDNSSKQYSVDEIAQQVEKELNYSAQLDSNILKAIESE 2312
             :||        ||....|:.|..|:....||:  :::|:...:||:|..:.||      .:..:
  Rat  2271 -ELECERGKGQVLQAQQEEQQLRHLQREGQSSR--ALEELKISLEKQLAQNNQL------CVALK 2326

  Fly  2313 EENNLDKKLQKGVQTEE---ETLPGTGNGTDDENFTGERELLNQLEALRAQLAVER----EQCEA 2370
            .|......|||.:|.|.   |.|.....|              ||..||..|..||    |..||
  Rat  2327 HERAAKDNLQKELQIEASRCEALLAQEKG--------------QLSELRKSLEAERSRSLELSEA 2377

  Fly  2371 MSKELLGEKQHSQDIQE----QDVIIIEAMRKRLETALDAEDELHKQLDQERERCERLQTQLTSL 2431
            :..|.|..:|.|::.||    ||.....|:.::|:.......||...|::.:::....|.||.:
  Rat  2378 LQHERLLTEQLSRNAQEACARQDTQAQHALLRKLKAEKARALELEAMLEKVQKQAAHTQQQLEA- 2441

  Fly  2432 QRAESRRNSSLLLKSPGDSPRKSPRADFESELGDRLRSEIKLLVAQN-------ERERERSADAQ 2489
             :|:.|   .|.|:.             |.|:...|||.:..|....       |||||::|..|
  Rat  2442 -QAQER---CLELRR-------------EKEVSGNLRSAVDALQTHKQELGCCLEREREKAAWLQ 2489

  Fly  2490 --------RSSERERQRYEKELQERVA-------YCERLKQEMEKLSRDKESAETELEHFNERLT 2539
                    |..::|.::.||.:..|.:       ..:|:|:::.:|...::..|.::|
  Rat  2490 AELEQLSARVKQQEARQDEKRMDRRSSREDLDKRKWQRVKEKLRELELQRQRDEHKIE------- 2547

  Fly  2540 LQASEIESLEARLVTLQEAETRRANTR---------TRQHQENVKLQAEIHELKSKLLAAEA--- 2592
                :::.|...|...:||.......|         ..|.||.   |.|:.:::.:||.|..
  Rat  2548 ----QLQRLVRELRWKEEAPGGNGPCRGSPCLGSLERDQFQEQ---QQELEKIRQQLLCAAGFLT 2605

  Fly  2593 --ARDCLDQKVTQLRFDVSRSGQRE-AKLAEALAQANDRLAHSTDDNVPAQFMQKM------KEI 2648
              ....:|:.:.    |.:.|.::. :.|...|.:....|      ::|..|.:||      :.:
  Rat  2606 SFTNHTVDRTIK----DWTSSNEKAVSSLMRTLEELKSEL------SMPTSFQKKMAAELQVQLM 2660

  Fly  2649 NALLAEN----------TQENRQMAETVQFLVGERIA---LQKKC-------------------- 2680
            |.||::|          |:|..::.:||..|  |:..   .||.|
  Rat  2661 NELLSDNDALTKAVGMATREKAELCKTVSRL--EKTLKHHTQKGCILNRQSKTPLKQDGMDLQSS 2723

  Fly  2681 ----------EELGGAGNTNVTELEERCRQLIGRYLRVESHRKALVYQKRYLKLTLEGYQASEQL 2735
                      :..||..||...::|    :|...|||.||.||||:|||:||.|.:.|:|.|||.
  Rat  2724 LPHSDPEWHPQTTGGDTNTCNIKME----KLYLHYLRAESFRKALIYQKKYLLLLIGGFQDSEQE 2784

  Fly  2736 ALQNLRGGAEQPPQRNIK-------KKFKTVALAIIAIQRIKYIGRIWHTGKRIVSKSVFTITQQ 2793
            .|..:......|.:.:.|       .:|:|....:||:.|::::.:.|..    |.:....|...
  Rat  2785 TLSMIAHLGVFPSKADKKVTASRPFTRFRTAVRVVIAVLRLRFLVKKWQE----VDRKGALIHHS 2845

  Fly  2794 RSPGLNLNVAPPQSPLPGPNSNLPTNN 2820
            ||.......:..|:...|..::|||.:
  Rat  2846 RSTRHGHRTSQRQNSPSGTRASLPTRD 2872

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Plp	NP_001027574.2	SMC_prok_B	1517..2569	CDD:274008	311/1480 (21%)
		Prefoldin	1517..>1573	CDD:298833	30/92 (33%)
		RILP-like	<2130..2237	CDD:304877	37/145 (26%)
		PACT_coil_coil	2704..2776	CDD:287467	28/78 (36%)
Pcnt	XP_038955131.1	PTZ00121	<154..858	CDD:173412	175/840 (21%)
		SMC_prok_B	<1043..1434	CDD:274008	91/402 (23%)
		Smc	1310..>1561	CDD:224117	49/257 (19%)
		SMC_prok_B	2081..>2384	CDD:274008	78/330 (24%)
		SMC_prok_B	2310..>2562	CDD:274008	69/300 (23%)
		PACT_coil_coil	2754..2832	CDD:402221	28/77 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	121	1.000	Domainoid score	I5568
eggNOG	1	0.900	-	-		E1_28NFK
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	121	1.000	Inparanoid score	I4661
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006988
OrthoInspector	1	1.000	-	-		otm44474
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR44981
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.050