DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Plp and Pcnt

DIOPT Version :9

Sequence 1:NP_001027574.2 Gene:Plp / 3772382 FlyBaseID:FBgn0086690 Length:2895 Species:Drosophila melanogaster
Sequence 2:XP_017169327.1 Gene:Pcnt / 18541 MGIID:102722 Length:3005 Species:Mus musculus


Alignment Length:3261 Identity:666/3261 - (20%)
Similarity:1159/3261 - (35%) Gaps:1014/3261 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   205 TTTTTSSSIEEEIEEAIEISEVEEQLNTPLESLSE-AAAYARPKDEQSSAKSLSSNPAEDEDADE 268
            |.....|::...::|       |..:.||...|.: .|.:..|....:...:..::.|::::..|
Mouse    38 TAKRKGSAVHASVQE-------EGSVATPNSELPQGGAVFESPSCSNTLEGTRGASAAQEQEDCE 95

  Fly   269 FRIDDAQLSGGQLAQHFLVDEDESEEGSDLPAASKVEVSLSSNDDDFDISLPLEQRKP-----VH 328
            ..:.|.|   ||                                         :|.:|     .|
Mouse    96 LDVTDLQ---GQ-----------------------------------------QQTQPPPPQTAH 116

  Fly   329 SLHEDDESVDQSLSNQSTTD------DVSELVEEPVHEMDDKTDGSAAISASAPQETQVDESQIT 387
            ||  :.|::..||:|..|..      ::.:..|..:.|:.:..:|..|...:..|..|..|.::.
Mouse   117 SL--ELEALRLSLNNMHTAQLELTQANLQKEKETALTELREMLNGRRAQELALLQSRQQCELELL 179

  Fly   388 DEQDHSMEEIVATNESIEVTYEAEETVNTSQKQDLIT----DLDEESEDQVHVDN--RPTSTLQA 446
            .|| |:.|:......|.:...|.:|.:.:..:::..|    ..|.|||.::.::|  :..|....
Mouse   180 REQ-HAREKEEMALRSGQEAAELKEKLRSEMEKNAQTIETLKQDWESERELCLENLRQELSLKHQ 243

  Fly   447 LKLPALQ---QPQIVERK------------AATALTTL---------RLQADV-------LEPLE 480
            .::..||   |.::.|:|            |..:|..|         :||.|:       |:.||
Mouse   244 SEMEGLQSQFQKELSEQKVELEKIFQAKHEAEVSLKNLEAQHQAAIKKLQEDLQSEHCQYLQDLE 308

  Fly   481 LTI--------LEMDDDENEEDD----DDEESSLQLMKLRLMAMNQQ-------MIVDNAPKLSP 526
            ...        ||::..:...:|    ..||..|...:|..|..|::       .::..|..|..
Mouse   309 QKFREKEKAKELELETLQASYEDLKAQSQEEIRLLWSQLESMKTNREELNGSWDPVLAQASHLEE 373

  Fly   527 TE------AEQTQVTSSSNNLEIKQMERV----PLTEFSKDVLEDITEESERL------------ 569
            .|      |:|.|...:.:..|::.: ||    .|.:..|...||:|...:||            
Mouse   374 LEHLRSGFAQQQQQERAQHESELEHL-RVYFEKKLKDAEKTYQEDLTVFQQRLQEAREDSLESTE 437

  Fly   570 LSMSTTMEEE------QDPPSLSLDESKTLLQPGAHKTGGSSSSLVSLNMLK--QLEAKVQELHT 626
            :|.|..:.||      ::||. .||     ||.|..|.   ..|||....:|  :.|.|:|::..
Mouse   438 ISSSCVLPEETSGREGKEPPD-PLD-----LQLGQPKV---QESLVEDCQVKLSKAEEKIQQMKE 493

  Fly   627 QLETKDNCLASLNLQLETARRESSAGPASARDSSSLMTNSTEYRTLQEELGGPTLDIYVEMSRRD 691
            :.:.|:   |...|..|..:||:....||.            :..|:|:.....|.|......|:
Mouse   494 EFQKKE---AEWELSREELKREAEERLASM------------FLELREKAESEKLSIISRFEHRE 543

  Fly   692 ELIAKLTDSLQQSLNVRDKLQVDADRLGGEVQNLRRQLQETLDAVKRSSAVWPDQEC--NPGQRI 754
            ..:..|.|  ||:..:     :|.:|...|.|...|||::.|    ....:.|..:|  .|....
Mouse   544 SSMRHLQD--QQAAQI-----LDLERSLMEQQGHLRQLEQEL----TRDDLLPCSQCGQEPAMAQ 597

  Fly   755 SEISMDLISESDD------DLDRHFLTDNEERGSRSSKERQLTQLQTNEELGLQASNPEWTPTFS 813
            .|.:..|:.|.:|      .....||.:.:|...:.:||:.                     .|.
Mouse   598 EEKNGALLREKEDCALQLLMAQNRFLEERKEIMEKFAKEQD---------------------AFL 641

  Fly   814 KQIEQFHTYLLPTEQRIFQMVQRKFDDYLNQQITLCRDLGAQELKIARDQWESEKLTSEQNQ--- 875
            :..::.|.:.|       |::|:..    .||:...|    .||:.......:|:|.|.:::   
Mouse   642 RDAQEKHNHEL-------QLLQQGH----QQQLLALR----MELETKHRSELTEQLASSESRRQA 691

  Fly   876 ---------QAAHAKQMEDLRKYFEHKCADLEKQFSDDVFSHKSQHQTGDSSSECSEVDQLPEEG 931
                     |..|..::..|.|.......:||..:..||.:.:.:||        ..::.|..|.
Mouse   692 LLETHVAELQVKHNAEISALEKRHLSNLDELESCYVADVQTIRDEHQ--------QALELLRAEL 748

  Fly   932 AAAVSSKEPSPRKRKRAELLLSPSHRQMTPCGLDSLGENTGKTEKDNTADIADLKIFYQTHIKEL 996
            ...:..||              ..||:|.             |::                ::.|
Mouse   749 EEQLQKKE--------------SCHREML-------------TQE----------------LENL 770

  Fly   997 KRAHEDQVRKLSDRIKFYERQQGDDDYKPATESPERTCPDQESAGGVANTSLIIIDEDELNFNNE 1061
            ||.|.::::.:.|.::.....|..::.|......:.....|:.|..:.|...:::::.:      
Mouse   771 KRQHAEELQSVRDSLRMEMSAQHIENGKGPAADLQGAHQQQDPAMALHNEGHLLVEDGD------ 829

  Fly  1062 SQVIQRIIEEYEKRLQEQLALARQDIATELEQQI--KSLLSENTVDDQHWPKELILLREKFTAKS 1124
                               |:.|...|..|..|.  :.|...:||:.|....||...:|...::.
Mouse   830 -------------------AVLRSVDAEGLLHQAGPQELGDAHTVEMQKSQAELAKPQELQASQD 875

  Fly  1125 QL-----EITQLNIKHAEEMSRLKLEFEKQLNRKNKRH------LTFDAARDLEQVICE----RD 1174
            |:     ::..||    .|:...:.|.| ||.::.:|.      |......|||....|    ||
Mouse   876 QVAQVRDKVFLLN----RELEECRAELE-QLQQRRERENQEGTTLICMLRADLELAQGEGKALRD 935

  Fly  1175 GLRELSKSFRSVLCRLAKCVAHCEEDLNATLSEEVQRLLFHSRSQDGGDDLEATISSSLNNTKHM 1239
            .||.|...|...|        .....|.:.:||....||.|   :|..|..:|.::::       
Mouse   936 ALRRLLDLFGDTL--------KAAVTLKSRISERAGLLLDH---EDAADTSDARLAAA------- 982

  Fly  1240 LRVPDVHS---LLEVVEDPSLVQFIDSKSNEEPS----EDFDLN-----DC-------LERLKSE 1285
             .:.|:.|   |||:  |.:|.:..::.|..|.|    |.|.::     ||       .:.|.:.
Mouse   983 -ALGDMWSDEGLLEI--DRTLPEGAETSSVCEISSHVCESFFISPENTLDCEQPIRRVYQSLSTA 1044

  Fly  1286 ASYLLHLSEDLHKQRTHDESSEHLDEPEKQEHELCCEAEDGLKTTGAVNQQVLSKFLRTNSLNDQ 1350
            ...||.::.|         ||:.|:| .:|.|. |.|.|                |...|    :
Mouse  1045 VEGLLEMALD---------SSKQLEE-ARQLHR-CVERE----------------FRHRN----E 1078

  Fly  1351 QMGVANQRKNSNPEAGKTHSSLPPDLQEHAGNASELSFQLVQLKNRLIKSEADRQNLQQQLSRTI 1415
            :|..|.|::          ..|...|:|.:.....|:.:|...|..|...:.::.:||:.|.:..
Mouse  1079 EMAQAMQKQ----------QELLERLREESAAKDRLALELHTAKGLLEGFKVEKVDLQEALGKKE 1133

  Fly  1416 DRNAELGQELQALRDQLSQLNSLNHTDYNEGYGLGTMK-SLQEQGLDQSSASFL-------ALQE 1472
            :...:|..||:.||.||.|......|...|...|...| :|..:..::.:.|.:       ||||
Mouse  1134 ESEQQLILELEDLRKQLQQAARELLTLKEEKSVLWNQKETLTNEAKEREAGSPVLPAHKDTALQE 1198

  Fly  1473 RARHLLSSS-PVKEQPSRDHGNSTVILLQMIEDFCREGDKVVEFSKKDR--------------ED 1522
            ....|.... ..::|..:|.   ..:|.||         :|:|...:|:              ..
Mouse  1199 EVESLTRVQWESRKQSEKDR---ATLLSQM---------RVLESELEDQLVQHRGCAQLAEEVAT 1251

  Fly  1523 LQSQIDTADKQLKDTRRFLEDQAAEREQERDEFQREIERLKAQLRDKEK------EHSSYANASE 1581
            |:.|:...||.|:..|:|::|||||||.||:|||:||:||:.|||...:      ..|......|
Mouse  1252 LKQQLAALDKHLRSQRQFMDDQAAEREHEREEFQQEIQRLEGQLRQAARPRPPGPRDSQCVQLDE 1316

  Fly  1582 EYAQLESQFRE--------------VNQQLC----------ESNAKRDKFEVELKASIDKIFVLR 1622
            |...|:.:.||              .:|||.          |:||...:..|:|:..::|.....
Mouse  1317 EVELLQEKLREKLDGFNELVIKKDFADQQLLIQEEEIKRLEETNASIQRQMVQLQEELEKQKKSM 1381

  Fly  1623 EIISELE------------TQVQTKALNE---EVLAEKAQQLEEYVSLQMRDNDILQQE---VHS 1669
            |.:.|.|            |.|....|:|   .:|.:.:..........:.:..:||.|   ||.
Mouse  1382 EELKEKEILKQENMGDLLLTTVSRSGLDEAGCPMLPQGSSSRGPEAQPDVTERALLQHENEVVHR 1446

  Fly  1670 LKTDIGEGYQSRIRVLEEKLKQ-SGPTAEQGVVLSQVAEKLRDIETTLDQKTKALE-----SLHN 1728
            ..::|.| .:|.|..|:|..:| ....||:...|.:|.|||:...:.:..|...:.     |||:
Mouse  1447 RNSEIDE-LKSLIENLQENQRQLQKDKAEEIEQLHEVIEKLQSELSLMGPKVHEVSDPQAGSLHS 1510

  Fly  1729 SNATSNSASLS----VTEDVSIHGSKE--PTAVGSPSH-PSLTVEGVQR----VTEKLDRH---- 1778
            ..|......|.    .:|..:...:||  ...:...:| .|..:|.:|:    ..|...||    
Mouse  1511 ELACLRGEGLGGQALRSELQAAQAAKEVFGQLLADQAHGHSQALEALQQRLQDAEEVAARHLAEL 1575

  Fly  1779 ------------------------TRVEEAAIKRIRDLEM------------------------- 1794
                                    .:.:||.|:: ||||:                         
Mouse  1576 EHCVALREAEVEAMASQIQEFAATLKAKEAIIEQ-RDLEIDAVNKWKVSHSLELEAILLALAHFR 1639

  Fly  1795 ---------------QVHQMRAGCVELQHE-----RDTLQGRME-EQTQ-RISTL-------QNR 1830
                           ::.|:|..|..|.|:     |..|:.||: :|.| .::::       .:.
Mouse  1640 HALEQQTCATPDEPPELRQLRVQCARLSHQLQVLYRPFLKCRMQLDQHQPHVASIGCANPCADDE 1704

  Fly  1831 LEEQ--------------RQRAEQLH--RTGTSDLNTRVHELQGEVQNLYEQLAARDKQMANMRQ 1879
            ||::              .|..|:|.  ..|.::|..:|.:||.|:.:....:|:||......:.
Mouse  1705 LEQEGVSNRLALAPHSLAAQAKEELEDCPLGKANLMAQVRQLQEELDHRVHSVASRDTNSETCKL 1769

  Fly  1880 QLQRSKEEITR---LETEVEVRTQPDRSL-VNKLQAEVQQKGAEIVKLKDKIRTEMINRLAIPDL 1940
            |.....|...|   ...|....:.||..| :.|...:|    .:|:|.:|     ::.::.:|| 
Mouse  1770 QQPNLSENGPRNHCCNGEESKPSPPDDVLNIAKTTWDV----IDIIKNQD-----LLVQVEMPD- 1824

  Fly  1941 METMLADKNDEIDHLRDQLEAKEKELQASQQEASQISSPSGAAGKQEGSGGKLSARTLSDIGSIT 2005
                              ...:||........:||.|..||:...:|.:..:.......|:.|  
Mouse  1825 ------------------FPTQEKLTSQGGPFSSQASGHSGSLLPEEAAEPQQDPVRALDLSS-- 1869

  Fly  2006 EFPEPDVERR-AAMRSLTALQMSEGAGGFLHQTMETSKEAVANLTHKRTDDLSGFIVPYP----- 2064
             :..|:|.|: .::....:|.::.|.|.....:::.|.:....|...   |:||.:. ||     
Mouse  1870 -WSSPEVVRKDPSLEPQHSLPLTPGVGTVSLHSVDISPDWTDPLLQA---DVSGLLC-YPGKSAS 1929

  Fly  2065 ------------------------------VNTFEH-------PHYFQALGVTAQSTDG------ 2086
                                          |.:|:.       .|........::.:||      
Mouse  1930 GQAPLWAVAPSAGKHHAERTATEKDVEDFIVTSFDSQELLTSPSHELARRSDGSRKSDGPDIAMM 1994

  Fly  2087 LTPGLVPRQINFSNLTEDSKLKTTSLLMHTP----------ELPRPTTPPEIHQLRVK------- 2134
            ||.|           :|.|:..||.|:....          :.|......|||..::|       
Mouse  1995 LTLG-----------SEGSETPTTDLVAAAAAAVPFSRRFVQSPGAMKEKEIHAKQMKALLQMVF 2048

  Fly  2135 -------------------------------------LSDLQTEKQRQQS------ELEKKLQDL 2156
                                                 ||::.|:|..::|      ..|:.|:.:
Mouse  2049 DESHQILALSESQDPSSALNKGEPRDPLDGFPRDSQALSEVTTDKGEKESLETHLTWSEELLRAI 2113

  Fly  2157 QKELEQEKEKLSRQAQTLQSYEESEAKYRLRIENLESKVLETAAQ--------AASDRENLRKEL 2213
            |:...:|:||...|.   :.|..:...|...::.|| ||::....        ..|||.:|..|:
Mouse  2114 QEVFAREQEKAELQP---RPYGSNLGDYNSLVQRLE-KVIQEQGDPQKVQDHLCLSDRSSLLAEI 2174

  Fly  2214 NCVSAA--------HEQCENAAAA--------------RKRELEKLNSEV---KVKADQLHAALR 2253
            ..:.|.        .|:.:...||              .:|::|.|..:|   |..|::|...|.
Mouse  2175 QALRAQLRMTHLQNQEKLQQLCAALTSTEARGSQREHQLRRQVELLAYKVEQEKCIANELQKTLS 2239

  Fly  2254 R----CADLELQVLTLERDLERLKN------SDNSSKQYSVDEIAQQVEKELNYS---------- 2298
            :    .:|:..:::..:..::.||:      .:|:|...|:|::.|:|.: |.|.          
Mouse  2240 KEQETASDVRKRLVVEQNAVQDLKSELHACKQENTSLLESLDKVQQEVLR-LRYGHVTWSYCGTS 2303

  Fly  2299 ------AQLD--SNILKAIESEEENNLDKKLQKGVQTEEETL------PGTGNGTDDENFTGERE 2349
                  |.||  ...||.:..|.|:...|......|.||:.|      ..:....::...:.|::
Mouse  2304 SASAGRAVLDGKEKELKVVLEELESERGKGQALQAQQEEQQLRYLQREGQSSRALEELKLSLEKQ 2368

  Fly  2350 LL--NQL-----------EALRAQLAVEREQCEAMSKELLGEKQHSQDIQEQDVIIIEAMRKR-- 2399
            |.  |||           :.|:.:|.:|..:|||:   |..||....::|:.    :||.|.|  
Mouse  2369 LAQNNQLCVALKHERAAKDNLQKELQIEASRCEAL---LAQEKGQLSELQKS----LEAERSRSL 2426

  Fly  2400 -LETALDAEDELHKQLDQ-ERERCERLQTQL--TSLQRAESRRNSSLLLKSPGDSPRKSP----- 2455
             |..||..|..|.:||.: .:|.|.|.:||:  ..|::.::.:..:|.|::..:..:|..     
Mouse  2427 ELSEALQHERLLTEQLSRNSQEACARQETQVQHALLRKLKAEKTRALELEAMLEKVQKQAAHTQQ 2491

  Fly  2456 -----------RADFESELGDRLRSEIKLLVAQN-------ERERERSADAQ--------RSSER 2494
                       ....|.|:...|||.:..|....       :||||::|..|        |..|:
Mouse  2492 QLEAQAQERCVELRREKEVSGNLRSAVDALRTHKQELGCCLQREREKAAWLQAELEQLSARVKEQ 2556

  Fly  2495 ERQRYEKELQERVAYCERLKQEMEKLSRDKESAETELEHFNERLTLQASEIESLEARLVTLQE-- 2557
            |.::..:.::.|   ..|...:..|..||||:.. |||...:|...:..:::.|...|...:|  
Mouse  2557 EARKDARRMERR---SSRADLDKRKWQRDKETLR-ELEIQRQRDEHKIEQLQRLVRELRWKEEVS 2617

  Fly  2558 -------AETRRANTRTRQHQENVKLQAEIHELKSKLL-AAEAARDCLDQKVTQLRFDVSRSGQR 2614
                   ....|.:....|.||.   |.|:.:::.:|| ||.......:..|.:...|.:.|.::
Mouse  2618 GGNGPCRGSPGRGSLERDQFQEQ---QQELEKIRQQLLCAAGLLTSFTNHTVDRTIKDWTSSNEK 2679

  Fly  2615 E-AKLAEALAQANDRLAHSTDDNVPAQFMQKM------KEINALLAEN----------TQENRQM 2662
            . :.|...|.:....|      ::|..|.:||      :.:|.||::|          |:|..::
Mouse  2680 AVSSLMRTLEELKSEL------SMPTSFQKKMTAELQVQLMNELLSDNDALTKAVGMATREKAEL 2738

  Fly  2663 AETVQFLVGERIA---LQKKC----------------------------EELGGAGNTNVTELEE 2696
            ..||..|  |:..   .||.|                            .....:|:||...:  
Mouse  2739 CRTVSRL--EKTLKHHTQKGCVLNRQSKSSLKQDGTDLQSSLRHSDPEWHSQTTSGDTNTCNI-- 2799

  Fly  2697 RCRQLIGRYLRVESHRKALVYQKRYLKLTLEGYQASEQLALQNLRGGAEQPPQRNIK-------K 2754
            :..:|...|||.||.||||:|||:||.|.:.|:|.|||..|..:......|.:.:.|       .
Mouse  2800 KMEKLYLHYLRAESFRKALIYQKKYLLLLIGGFQDSEQETLSMIAHLGVFPSKADKKITMSRPFT 2864

  Fly  2755 KFKTVALAIIAIQRIKYIGRIW----HTGKRIVSKSV----FTITQQRSPGLNLNVAPPQSPLPG 2811
            ||:|....:||:.|::::.:.|    ..|..:..||.    .|..:||||.             |
Mouse  2865 KFRTAVRVVIAVLRLRFLVKKWQEVDRKGALVHPKSTRHGHRTSQRQRSPS-------------G 2916

  Fly  2812 PNSNLPTNNNN 2822
            |.::|||.:.:
Mouse  2917 PRASLPTRDTS 2927

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PlpNP_001027574.2 SMC_prok_B 1517..2569 CDD:274008 295/1467 (20%)
Prefoldin 1517..>1573 CDD:298833 27/75 (36%)
RILP-like <2130..2237 CDD:304877 30/186 (16%)
PACT_coil_coil 2704..2776 CDD:287467 29/78 (37%)
PcntXP_017169327.1 PTZ00121 <133..647 CDD:173412 117/571 (20%)
Smc <475..1387 CDD:224117 235/1128 (21%)
SMC_prok_B 1230..>1565 CDD:274008 82/335 (24%)
Smc <2191..2597 CDD:224117 94/417 (23%)
PACT_coil_coil 2808..2886 CDD:371091 29/77 (38%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 123 1.000 Domainoid score I5573
eggNOG 1 0.900 - - E1_28NFK
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0006988
OrthoInspector 1 1.000 - - otm42410
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR44981
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5050
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
77.030

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