DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tyler and MTM1

DIOPT Version :9

Sequence 1:	NP_608327.2	Gene:	Tyler / 3772349	FlyBaseID:	FBgn0031038	Length:	441	Species:	Drosophila melanogaster
Sequence 2:	NP_567790.1	Gene:	MTM1 / 828907	AraportID:	AT4G27940	Length:	413	Species:	Arabidopsis thaliana

Alignment Length:	419	Identity:	100/419 - (23%)
Similarity:	167/419 - (39%)	Gaps:	120/419 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 QQVVSALVGGLITTFVVTPLEVVKTRVQTQ-------HAIRQRPTVSKLCYVYHNGLMTHVCRSS 104
            ::|.||....:::...:.||:|||||:|.|       |.:..  ::.::.:...| :|....|.|
plant    63 ERVFSAAGAAVLSAVTLNPLDVVKTRLQAQAAGMSYSHPLSN--SIGRMAFFGPN-MMFADLRCS 124

  Fly   105 DICVPKPGRD------PQNLRPLRGAMDAFVKIVCTSGFSGLWAGLSPTLVSALPSTIIYFLTYE 163
            ..|. :.|.:      |.:....:|..|.|.||:...|...||.|.:..|..|:|...||...|:
plant   125 PSCA-RAGVEGTVSICPPDCFQYKGTFDVFTKIIRQEGLGRLWRGTNAGLALAVPMVGIYLPFYD 188

  Fly   164 YIKNSLSHIYLVSQKFEESGMKDQVPGADGGDPLDQATRGINVSATAPVSTASLPYYVPMASGIC 228
            ..:|.|..:           .:::.|                          ::.:.||..:|..
plant   189 MFRNRLEEL-----------SREKAP--------------------------AMTFCVPTVAGSL 216

  Fly   229 SRTIVVTAITPIEMVRIKMQ----------------------SEYMTYAELWRVLRSLIRQHGIL 271
            :|::..|...||::.|.:||                      ||..|...|...|      |...
plant   217 ARSLACTVCYPIDLARTRMQAFKEAKAGVKPPGVFKTLVGVFSEVRTANNLESSL------HNYR 275

  Fly   272 GLWRGWPPTVMRDAPFSGTYWAVYEAIKR-----AFSVTEPTFLF--SFLTGAISGAVATFVTMP 329
            |||||....:.||.|||...|:..|.||:     |.:.|....:|  :|..|.|:|::|...|.|
plant   276 GLWRGLGAQLARDVPFSAICWSTLEPIKKRLLGVAGNDTNLVGVFGATFSAGFIAGSIAAAATCP 340

  Fly   330 FDLITTHTQIELGQDVLYEEIGAGTGAGTGTGAGARPKTP-QSAVANSRPSVLSRMRQIYRLQGV 393
            .|:..|..|||                          |.| ::.:..:|.:::    :::|..|:
plant   341 LDVARTRRQIE--------------------------KDPGRALMMTTRQTLI----EVWRDGGM 375

  Fly   394 RGLYVGVMPRMLRVVPACAIMISTFEYSK 422
            |||::|:.||:.|..|:..|::|.:|..|
plant   376 RGLFMGMGPRVARAGPSVGIVVSFYEVVK 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tyler	NP_608327.2	Mito_carr	41..171	CDD:278578	37/136 (27%)
		Mito_carr	216..302	CDD:278578	30/112 (27%)
		Mito_carr	306..429	CDD:278578	30/120 (25%)
MTM1	NP_567790.1	Mito_carr	57..194	CDD:395101	36/134 (27%)
		Mito_carr	212..308	CDD:395101	28/101 (28%)
		Mito_carr	320..410	CDD:395101	30/115 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	64	1.000	Domainoid score	I3661
eggNOG	1	0.900	-	-		E1_KOG0761
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	153	1.000	Inparanoid score	I1691
OMA	1	1.010	-	-		QHG53824
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001594
OrthoInspector	1	1.000	-	-		mtm1053
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45760
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1001
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	10.020