Protein Alignment Tyler and SLC25A39

DIOPT Version :10

• Sequence 1: NP_608327.2
• Gene: Tyler / 3772349
• FlyBaseID: FBgn0031038
• Length: 441
• Species: Drosophila melanogaster
• Sequence 2: XP_011523182.1
• Gene: SLC25A39 / 51629
• HGNCID: 24279
• Length: 365
• Species: Homo sapiens
• Alignment Length: 428
• Identity: 135/428 - (31%)
• Similarity: 198/428 - (46%)
• Gaps: 115/428 - (26%)

  Fly    43 IKPMQQVVSALVGGLITTFVVTPLEVVKTRVQTQHAIRQRPTV---------------SKL---- 88
            |.|:||:|::..|.::|:..:|||:|||.|:|:     |||::               :||
Human     9 ISPLQQMVASGTGAVVTSLFMTPLDVVKVRLQS-----QRPSMASELMPSSRLWSLSYTKLPSSL 68

  Fly    89 -----CYVYHNGLM--THVCRSSDICVPKPGRDPQNLRPLRGAMDAFVKIVCTSGFSGLWAGLSP 146
                 |.:|.||::  .::|.:...|... .:||..   ..|.||||||||...|...||:||..
Human    69 QSTGKCLLYCNGVLEPLYLCPNGARCATW-FQDPTR---FTGTMDAFVKIVRHEGTRTLWSGLPA 129

  Fly   147 TLVSALPSTIIYFLTYEYIKNSLSHIYLVSQKFEESGMKDQVPGADGGDPLDQATRGINVSATAP 211
            |||..:|:|.|||..|:.:|..|....|.|.
Human   130 TLVMTVPATAIYFTAYDQLKAFLCGRALTSD---------------------------------- 160

  Fly   212 VSTASLPYYVPMASGICSRTIVVTAITPIEMVRIKMQSEYMTYAELWRVLRSLIRQHGILGLWRG 276
                   .|.||.:|..:|...||.|:|:|::|.|:|:::::|.||...:|:.:.|.|...||.|
Human   161 -------LYAPMVAGALARLGTVTVISPLELMRTKLQAQHVSYRELGACVRTAVAQGGWRSLWLG 218

  Fly   277 WPPTVMRDAPFS------GTYWAVYEAIK---RAFSVTEPTFL-FSFLTGAISGAVATFVTMPFD 331
            |.||.:||.|||      ..||..||.:|   ..|...:.|.: .||:.|.|||.||..:|:|||
Human   219 WGPTALRDVPFSVHPPPQALYWFNYELVKSWLNGFRPKDQTSVGMSFVAGGISGTVAAVLTLPFD 283

  Fly   332 LITTHTQIELGQDVLYEEIGAGTGAGTGTGAGARPKTPQSAVANSRPSVLSR---MRQIYRLQGV 393
            ::.|..|:.||                          ...||..:...|.|.   :|:|....|.
Human   284 VVKTQRQVALG--------------------------AMEAVRVNPLHVDSTWLLLRRIRAESGT 322

  Fly   394 RGLYVGVMPRMLRVVPACAIMISTFEYSKSFFFHYNLD 431
            :||:.|.:||:::..|:|||||||:|:.||||...|.|
Human   323 KGLFAGFLPRIIKAAPSCAIMISTYEFGKSFFQRLNQD 360

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tyler	NP_608327.2	Mito_carr	41..171	CDD:395101	53/153 (35%)
		Mito_carr	216..303	CDD:395101	35/95 (37%)
		Mito_carr	306..429	CDD:395101	42/126 (33%)
SLC25A39	XP_011523182.1	Mito_carr	9..152	CDD:395101	52/151 (34%)
		Mito_carr	161..252	CDD:395101	35/90 (39%)
		Mito_carr	257..356	CDD:395101	42/124 (34%)