DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tyler and slc25a40

DIOPT Version :9

Sequence 1:	NP_608327.2	Gene:	Tyler / 3772349	FlyBaseID:	FBgn0031038	Length:	441	Species:	Drosophila melanogaster
Sequence 2:	NP_001002360.1	Gene:	slc25a40 / 436633	ZFINID:	ZDB-GENE-040718-52	Length:	353	Species:	Danio rerio

Alignment Length:	418	Identity:	144/418 - (34%)
Similarity:	215/418 - (51%)	Gaps:	93/418 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LECKEMDPLRLTTLILSADPRYRIKPMQQVVSALVGGLITTFVVTPLEVVKTRVQTQHAIRQRPT 84
            :.|:|..|          .|...|.|.||::::..|.:||:.:||||:|||.|:|.|    :.|.
Zfish     1 MSCQESSP----------GPPGDITPFQQMMASCSGAIITSLLVTPLDVVKIRLQAQ----KNPF 51

  Fly    85 VSKLCYVYHNGLMTHVC----RSSDICVPKPGRDPQNLRPLRGAMDAFVKIVCTSGFSGLWAGLS 145
            ....|:||.||||.|:|    .::.:....||.       ..|.:|||:||:...|...||:||.
Zfish    52 PKGKCFVYCNGLMDHICVCENGNTKVWYKAPGH-------FSGTLDAFLKIIRMEGIRSLWSGLP 109

  Fly   146 PTLVSALPSTIIYFLTYEYIKNSLSHIYLVSQKFEESGMKDQVPGADGGDPLDQATRGINVSATA 210
            |||:.|:|:|:|||..|:.:      ..|:..|.              ||..|.|
Zfish   110 PTLIMAVPATVIYFTCYDQL------FALLKLKM--------------GDRSDLA---------- 144

  Fly   211 PVSTASLPYYVPMASGICSRTIVVTAITPIEMVRIKMQSEYMTYAELWRVLRSLIRQHGILGLWR 275
                       |:.:|..:|....|.|:|:|::|.|||||..:|.|:..|:||.::..|:..|||
Zfish   145 -----------PLFAGAIARVGSATVISPLELIRTKMQSEKQSYREMSAVIRSALKNEGLRSLWR 198

  Fly   276 GWPPTVMRDAPFSGTYWAVYEAIK----RAFSVTEPTFLFSFLTGAISGAVATFVTMPFDLITTH 336
            ||.||::||.|||..||..||..|    :.:|.:|||...:|..||:||::|:.:|:|||::.|.
Zfish   199 GWGPTLLRDVPFSAMYWFNYEKGKWWLCKRYSCSEPTVAITFTAGALSGSIASIITLPFDVVKTK 263

  Fly   337 TQIELGQDVLYEEIGAGTGAGTGTGAGARPKTPQSAVANSRPSVLSRMRQIYRLQGVRGLYVGVM 401
            .|:|:|:                    .:.....:.|::|..||   |::|....||.||:.|.|
Zfish   264 RQVEMGE--------------------LQTMKLSTQVSSSTCSV---MKRIVAENGVSGLFAGFM 305

  Fly   402 PRMLRVVPACAIMISTFEYSKSFFFHYN 429
            ||:::|.|||||||||:|:.|:||..||
Zfish   306 PRLIKVAPACAIMISTYEFGKAFFRKYN 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tyler	NP_608327.2	Mito_carr	41..171	CDD:278578	50/133 (38%)
		Mito_carr	216..302	CDD:278578	36/89 (40%)
		Mito_carr	306..429	CDD:278578	45/122 (37%)
slc25a40	NP_001002360.1	Mito_carr	12..136	CDD:278578	51/140 (36%)
		Solcar 1	14..132		50/134 (37%)
		PTZ00169	27..327	CDD:240302	130/374 (35%)
		Solcar 2	140..224		38/104 (37%)
		Mito_carr	143..229	CDD:278578	37/106 (35%)
		Mito_carr	232..333	CDD:278578	45/123 (37%)
		Solcar 3	234..328		42/116 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	94	1.000	Domainoid score	I7403
eggNOG	1	0.900	-	-		E1_KOG0761
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53824
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001594
OrthoInspector	1	1.000	-	-		mtm6545
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45760
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1001
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.880