DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tyler and slc25a40

DIOPT Version :9

Sequence 1:	NP_608327.2	Gene:	Tyler / 3772349	FlyBaseID:	FBgn0031038	Length:	441	Species:	Drosophila melanogaster
Sequence 2:	NP_989316.1	Gene:	slc25a40 / 394941	XenbaseID:	XB-GENE-1003942	Length:	341	Species:	Xenopus tropicalis

Alignment Length:	402	Identity:	141/402 - (35%)
Similarity:	209/402 - (51%)	Gaps:	89/402 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 IKPMQQVVSALVGGLITTFVVTPLEVVKTRVQTQHAIRQRPTVSKLCYVYHNGLMTHVCRSSDIC 107
            |.|.||::::.:|.|:|:|.||||:|||.|:|.|    .:|.:...|:||.||||.|:|    :|
Frog    14 ITPSQQMIASSMGALLTSFFVTPLDVVKIRLQAQ----SKPFIKGKCFVYCNGLMDHLC----LC 70

  Fly   108 VPKPG----RDPQNLRPLRGAMDAFVKIVCTSGFSGLWAGLSPTLVSALPSTIIYFLTYEYIKNS 168
            ....|    |.|.:   .||..||||:|:...|...||:||.||||.|:|:|:|||..|:.:::.
Frog    71 TNGNGKAWYRAPGH---FRGTTDAFVQIIRNEGIKSLWSGLPPTLVMAVPATVIYFTCYDQLRDI 132

  Fly   169 LSHIYLVSQKFEESGMKDQVPGADGGDPLDQATRGINVSATAPVSTASLPYYVPMAS---GICSR 230
            |                                            ..|:|....:||   |..:|
Frog   133 L--------------------------------------------IRSMPERAEIASLVAGATAR 153

  Fly   231 TIVVTAITPIEMVRIKMQSEYMTYAELWRVLRSLIRQHGILGLWRGWPPTVMRDAPFSGTYWAVY 295
            ....|.|:|:|::|.|||...::|.||.:.::|.:.:.|.|.||:||.|||:||.|||..||..|
Frog   154 LWSATLISPLELIRTKMQYRPLSYKELRQCIQSSVAKDGWLALWKGWGPTVLRDVPFSALYWHNY 218

  Fly   296 EAIKRA----FSVTEPTFLFSFLTGAISGAVATFVTMPFDLITTHTQIELGQDVLYEEIGAGTGA 356
            |.:|::    ::..:|||..||..||:||::|..||:|||::.|..|:|:|:..::
Frog   219 ELVKQSLCQRYNTLQPTFAISFTAGAVSGSIAAIVTLPFDVVKTRRQVEVGELEMF--------- 274

  Fly   357 GTGTGAGARPKTPQSAVANSRPSVLSRMRQIYRLQGVRGLYVGVMPRMLRVVPACAIMISTFEYS 421
               |.:..|..           |....||.|....|..||:.|::||:::|.|||||||||:|:.
Frog   275 ---TYSQKRSS-----------STWKLMRAIVIENGFGGLFAGLIPRLIKVAPACAIMISTYEFG 325

  Fly   422 KSFFFHYNLDLQ 433
            ||||...|.:.|
Frog   326 KSFFRKLNNERQ 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tyler	NP_608327.2	Mito_carr	41..171	CDD:278578	56/131 (43%)
		Mito_carr	216..302	CDD:278578	37/92 (40%)
		Mito_carr	306..429	CDD:278578	46/122 (38%)
slc25a40	NP_989316.1	Mito_carr	14..135	CDD:365909	56/175 (32%)
		Solcar 1	14..132		55/128 (43%)
		Solcar 2	140..224		35/83 (42%)
		Mito_carr	143..225	CDD:365909	35/81 (43%)
		Mito_carr	234..331	CDD:365909	46/119 (39%)
		Solcar 3	234..328		43/116 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	87	1.000	Domainoid score	I7858
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	295	1.000	Inparanoid score	I2686
OMA	1	1.010	-	-		QHG53824
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001594
OrthoInspector	1	1.000	-	-		mtm9516
Panther	1	1.100	-	-	O	PTHR45760
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1001
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.070