DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tyler and slc25a39

DIOPT Version :9

Sequence 1:	NP_608327.2	Gene:	Tyler / 3772349	FlyBaseID:	FBgn0031038	Length:	441	Species:	Drosophila melanogaster
Sequence 2:	NP_956780.1	Gene:	slc25a39 / 393458	ZFINID:	ZDB-GENE-040426-1250	Length:	359	Species:	Danio rerio

Alignment Length:	415	Identity:	146/415 - (35%)
Similarity:	212/415 - (51%)	Gaps:	102/415 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 IKPMQQVVSALVGGLITTFVVTPLEVVKTRVQTQH-------AIRQRP-----TVSK-LCYVYHN 94
            |.|:||::::..|.::|:..||||:|||.|:|.|.       |...||     ..|| .|::|.|
Zfish    13 ITPVQQMLASGTGAVLTSLFVTPLDVVKIRLQAQQTPLFQAIAAESRPWFRVTRPSKWKCFLYCN 77

  Fly    95 GLMTH--VCRSSDICVPKPGRDPQNL----RPLRGAMDAFVKIVCTSGFSGLWAGLSPTLVSALP 153
            |||.|  ||::...|        .||    ....|.:||||||....|...||:||.||||.|:|
Zfish    78 GLMDHVYVCQNMSSC--------SNLYKTSTHFSGTLDAFVKITHNEGLRSLWSGLPPTLVMAVP 134

  Fly   154 STIIYFLTYEYIKNSLSHIYLVSQKFEESGMKDQVPGADGGDPLDQATRGINVSATAPVSTASLP 218
            :|:|||..|:.:::.|.:                                            |:.
Zfish   135 ATVIYFTCYDQLRDFLCY--------------------------------------------SMG 155

  Fly   219 Y---YVPMASGICSRTIVVTAITPIEMVRIKMQSEYMTYAELWRVLRSLIRQHGILGLWRGWPPT 280
            |   ::|:.:|..:|...|:.|:|:|:||.||||..:.|:||...:||.:.|.|.|.|||||.||
Zfish   156 YHGDHIPLIAGGLARLGAVSVISPLELVRTKMQSRRLQYSELMVCIRSSVAQDGWLSLWRGWGPT 220

  Fly   281 VMRDAPFSGTYWAVYEAIK----RAFSVTEPTFLFSFLTGAISGAVATFVTMPFDLITTHTQIEL 341
            |:||.|||..||..||.:|    ..:...:.:|..||..||:|||:|..:|:|||::.|..||:|
Zfish   221 VLRDVPFSALYWFNYELVKAQLCEHYRTPQASFTISFTAGAVSGAIAAVLTLPFDVVKTRRQIQL 285

  Fly   342 GQDVLYEEIGAGTGAGTGTGAGARPKTPQSAVANSRP-SVLSRMRQIYRLQGVRGLYVGVMPRML 405
            |:   .|.:|                    ||:..:| |..:.||.|:...|.:||:.|.:||::
Zfish   286 GE---MEALG--------------------AVSMKKPSSTWNMMRNIWIDMGYKGLFAGFLPRVI 327

  Fly   406 RVVPACAIMISTFEYSKSFFFHYNL 430
            :|.||||:||||:|:.|:||...||
Zfish   328 KVAPACAVMISTYEFGKTFFQERNL 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tyler	NP_608327.2	Mito_carr	41..171	CDD:278578	57/146 (39%)
		Mito_carr	216..302	CDD:278578	41/92 (45%)
		Mito_carr	306..429	CDD:278578	46/123 (37%)
slc25a39	NP_956780.1	Mito_carr	13..150	CDD:278578	56/144 (39%)
		Solcar 1	13..149		56/143 (39%)
		Solcar 2	157..241		39/83 (47%)
		Mito_carr	163..246	CDD:278578	38/82 (46%)
		Mito_carr	250..351	CDD:278578	46/123 (37%)
		Solcar 3	251..346		44/117 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	94	1.000	Domainoid score	I7403
eggNOG	1	0.900	-	-		E1_KOG0761
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53824
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001594
OrthoInspector	1	1.000	-	-		mtm6545
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45760
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1001
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.880