DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tyler and SPBP23A10.06

DIOPT Version :9

Sequence 1:	NP_608327.2	Gene:	Tyler / 3772349	FlyBaseID:	FBgn0031038	Length:	441	Species:	Drosophila melanogaster
Sequence 2:	NP_595818.1	Gene:	SPBP23A10.06 / 2541312	PomBaseID:	SPBP23A10.06	Length:	335	Species:	Schizosaccharomyces pombe

Alignment Length:	440	Identity:	124/440 - (28%)
Similarity:	190/440 - (43%)	Gaps:	135/440 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 MENGGEEEGCRLECKEMDPLRLTTLILSADPRYRIKPMQQVVSALVGGLITTFVVTPLEVVKTRV 73
            |:.|...||...:           |.::|:|  .:||:.:::||.||.:|||..||||:|||||:
pombe     1 MQIGAATEGVEAD-----------LSVNAEP--DVKPIAKMLSACVGSVITTLTVTPLDVVKTRL 52

  Fly    74 QTQHAIRQRPTVSKLCYVYHNGLMTHVCRSSDICVPKPGRDPQNLRPLRGAMDAFVKIVCTSGFS 138
            |:: :|.|..:             |....|:.|.    |:.....:||.|.:....:|....|..
pombe    53 QSE-SISQYSS-------------TQPISSAKIL----GKGRPAPKPLGGPVSGLYQIARHEGVR 99

  Fly   139 GLWAGLSPTLVSALPSTIIYFLTYEYIKNSLSHIYLVSQKFEESGMKDQVPGADGGDPLDQATRG 203
            .||.||.|:|...||:..:.||.||    .|..:|                 :|.|.|
pombe   100 SLWRGLVPSLTMLLPANTVQFLGYE----QLLPLY-----------------SDWGFP------- 136

  Fly   204 INVSATAPVSTASLPYYVPMASGICSRTIVVTAITPIEMVRIKMQSEYMTYA---------ELWR 259
                |.|.::.||            :|||..|.::|||:.|.::|:....|.         |::.
pombe   137 ----AAAAIAGAS------------ARTISATIVSPIELFRTRVQAVGGHYPPGHAREIANEVFD 185

  Fly   260 VLRSLIRQHGILGLWRGWPPTVMRDAPFSGTYWAVYEAIK---------RAFSVTEPT--FLFSF 313
            .|:.:|.|.|||.||.|...|:.||.|||..||..||.|:         :|||.::.|  ...:|
pombe   186 GLKLMIHQKGILNLWSGVSVTLWRDVPFSAFYWWSYERIRLFLLGHPSLQAFSSSQSTKDLYINF 250

  Fly   314 LTGAISGAVATFVTMPFDLITTHTQIELGQDVLYEEIGAGTGAGTGTGAGARPKTPQSAVANSRP 378
            ::|.|||.:||.:|.|||:..|..|:                                     ..
pombe   251 VSGGISGTLATLLTQPFDVSKTAKQV-------------------------------------HG 278

  Fly   379 SVLSR---MRQIYRLQGVRGLYVGVMPRMLRVVPACAIMISTFEYSKSFF 425
            ..|:|   |..:::..|.:.|:.|.:||.::|.|:||||||::..:|.:|
pombe   279 HTLTRGQFMLTLWKRGGPKALWKGTLPRCVKVAPSCAIMISSYHLTKKYF 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tyler	NP_608327.2	Mito_carr	41..171	CDD:278578	43/129 (33%)
		Mito_carr	216..302	CDD:278578	32/103 (31%)
		Mito_carr	306..429	CDD:278578	32/125 (26%)
SPBP23A10.06	NP_595818.1	Mito_carr	21..132	CDD:278578	44/149 (30%)
		Mito_carr	148..231	CDD:278578	30/82 (37%)
		Mito_carr	242..331	CDD:278578	32/124 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	73	1.000	Domainoid score	I2546
eggNOG	1	0.900	-	-		E1_KOG0761
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	171	1.000	Inparanoid score	I1181
OMA	1	1.010	-	-		QHG53824
OrthoFinder	1	1.000	-	-		FOG0001594
OrthoInspector	1	1.000	-	-		otm47262
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45760
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1001
TreeFam	1	0.960	-	-
	11	10.930