DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LSm-4 and Commd5

DIOPT Version :9

Sequence 1:	NP_001027237.1	Gene:	LSm-4 / 3772280	FlyBaseID:	FBgn0067622	Length:	205	Species:	Drosophila melanogaster
Sequence 2:	NP_079812.1	Gene:	Commd5 / 66398	MGIID:	1913648	Length:	224	Species:	Mus musculus

Alignment Length:	194	Identity:	41/194 - (21%)
Similarity:	85/194 - (43%)	Gaps:	26/194 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LTKSMLRVLIQVSVHYIESKKSSSEVLSLA---------LNKLTNGGHEIPPNFCELFTMVFLTM 78
            |.:|..|.|:::.|..:..|.....|..|.         |..|..|.|.:              :
Mouse    43 LDRSTFRKLLKLVVGALHGKDCREAVQHLGASANLSEERLAVLLAGTHTL--------------L 93

  Fly    79 QIFLRYPKGVVKHHELRKCLMDDLNLTEEYVEDICKVLL-NHRDVLSKNFSDTKMDRVKMSKLQW 142
            |..||.|...:|....:..| .:|.:.::.:.|:..:.. :.|.:|............::|..:|
Mouse    94 QQALRLPPASLKPDAFQDEL-QELGIPQDMIGDLASLAFGSQRPLLDSVAQQQGSSLPRVSNFRW 157

  Fly   143 RINISLSLNTVQID-KPTIVLHFKLQNKEYRTLELPLSMFQQVRYNIALLLNELQSLQSRLALK 205
            |:::::|.:..... :|::::..||.:......|:|::.||::||::||:|.|:..|:.:...|
Mouse   158 RVDVAISTSAQSRSLQPSVLMQLKLTDGSAHRFEVPIAKFQELRYSVALVLKEMAELERKCERK 221

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LSm-4	NP_001027237.1	HCaRG	22..196	CDD:284632	39/183 (21%)
Commd5	NP_079812.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
Commd5	NP_079812.1	Commd5_HCaRG	115..224	CDD:240101	23/107 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834658
Domainoid	1	1.000	44	1.000	Domainoid score	I12276
eggNOG	1	0.900	-	-		E1_295KW
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	51	1.000	Inparanoid score	I5461
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48482
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008039
OrthoInspector	1	1.000	-	-		oto93118
orthoMCL	1	0.900	-	-		OOG6_106615
Panther	1	1.100	-	-	LDO	PTHR15666
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5085
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.830