Protein Alignment Mvk and MVK

DIOPT Version :10

• Sequence 1: NP_001027412.1
• Gene: Mvk / 3772247
• FlyBaseID: FBgn0061359
• Length: 390
• Species: Drosophila melanogaster
• Sequence 2: XP_047284829.1
• Gene: MVK / 4598
• HGNCID: 7530
• Length: 496
• Species: Homo sapiens
• Alignment Length: 414
• Identity: 139/414 - (33%)
• Similarity: 200/414 - (48%)
• Gaps: 65/414 - (15%)

  Fly     6 VHSPGKVILHGEHAVVYHRPALAAVVGLGTTLRFRQLEDSQVASFQLEALNCTLEIQLPEFNGFL 70
            |.:|||||||||||||:.:.|||..:.|.|.||.:...:.:|            ::.||......
Human   108 VSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKV------------DLSLPNIGIKR 160

  Fly    71 AEFRSKYPSDSTANLLEA-VRAEVSKQLER----SGGNAPKQHTQR----AFISIYYLLAGAVLS 126
            |...::..|..|:.|.:. |....|:|:|:    :|.......|:|    ||:.:|..:.
Human   161 AWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSIC----- 220

  Fly   127 APGDKKLTLQTGFQVQVDSQLTVGAGLGSSASFGAALATTFLILAGHF-----DRD--SYLSEAN 184
                :|........:.|.|:|..||||||||::...||...|.:....     |.|  :..::.:
Human   221 ----RKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKED 281

  Fly   185 QALISSWAYESERVNHGTPSGLDNTVCTYGGMLRYVKGQGFQSLKIQKPLNILLVDSRVSRSTAD 249
            ..||:.||::.||:.||.|||:||.|.|:||.|||.:|: ..|||....|.|||.:::|.|:|..
Human   282 LELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGK-ISSLKRSPALQILLTNTKVPRNTRA 345

  Fly   250 IVAKVRHLGDAFPQL-------IEAIWQACE----ELVAAAVPLYESFGNAQDDSSKFEQLERLF 303
            :||.||:....||::       |:||...||    |:..|..|            .::..||.|.
Human   346 LVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAP------------EQYLVLEELI 398

  Fly   304 QINNDLLKAIGVSHPKLEQIFTIAFKRGFFSKLTGAGAGGYVIVLLPENYECNEVYWKLKEELES 368
            .:|...|.|:||.|..|:|:..:...||..|||||||.||..|.||....|..||. ..|:.|.|
Human   399 DMNQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVE-ATKQALTS 462

  Fly   369 AGFGVHVTTAGGEGLRV---SSLD 389
            .||....|:.|..|:.:   :|||
Human   463 CGFDCLETSIGAPGVSIHSATSLD 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mvk	NP_001027412.1	mevalon_kin	8..348	CDD:273130	122/366 (33%)
MVK	XP_047284829.1	PLN02677	110..479	CDD:215363	135/403 (33%)